Objective – to study the effects of nonspecific cytoprotective therapy on the clinical manifestations, course of illness, and measures of the stress system in patients with different grades of chronic cerebral ischemia (CCI). Materials and methods. The study included 266 patients aged 35–55 years who received basal and nonspecific cytoprotective therapy. Changes in subjective and objective symptoms of CCI were studied, along with clinical outcomes at one year of follow-up, with assessment of the state of the stress system. Treatment effects on stress resistance were evaluated in terms of changes in blood stress reactions. Results and conclusions. This open, comparative, randomized study showed that inclusion of a nonspecific cytoprotective agent (Cytoflavin) in the therapeutic complex increased the efficacy of treatment of the clinical manifestations of CCI. An increase in the proportion of favorable outcomes at one year of follow-up was associated with optimization of the activity of the stress system using nonspecific cytoprotective therapy, accompanied by increases in stress resistance.
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