Challenges with Percent Predicted Maximum VO2 in Patients with Heart Failure.

Purpose: To describe the influence of different equations to predict maximum oxygen uptake (MVO2) on the percent predicted MVO2 (ppMVO2) and the resultant categorization of patients with heart failure with reduced ejection fraction (HFrEF) into high or low risk. Methods: In this retrospective cohort study, ppMVO2 was calculated using six different equations to predict MVO2 among 1,168 patients with HFrEF (33% women). Repeated measures analysis of variance was used to compare within-subject differences in mean ppMVO2 between the prediction equations. Cochrane's Q test was used to compare the within-subject difference in the proportion of patients with ppMVO2 =75% (low risk) between the five prediction equations. Results: The ppMVO2 varied significantly (P<.001 between the mvo2 prediction equations with mean percentile ppmvo2 ranging from to in men and women. significant variation was also observed for proportion of patients>=75% in men and women. Conclusions: Statistically significant and clinically meaningful variations in the ppMVO2 are observed based on the reference equation used to predict MVO2. Future writing committees should specify the preferred reference equation when identifying a ppMVO2 criterion in guideline statements. (C) 2017 American College of Sports Medicine

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