Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults

Abstract

Primary ageing markedly attenuates cutaneous vasodilatation and the increase in cardiac output during passive heating. However, it remains unclear if these responses are maximally restrained by age-related changes in cutaneous microvascular and cardiac functions. We hypothesized that rapid volume loading performed during heat stress would increase cardiac output in older adults without parallel increases in cutaneous vasodilatation. Twelve young (Y: 26 ± 5 yrs) and ten older (O: 69 ± 3 yrs) healthy adults were passively heated until core temperature increased by 1.5°C. Cardiac output (thermodilution), forearm vascular conductance (FVC, venous occlusion plethysmography) and cutaneous vascular conductance (CVC, laser-Doppler) were measured before and after rapid infusion of warmed saline (15 mL kg⁻¹, ∼7 min). While heat stressed, but prior to saline infusion, cardiac output (O: 6.8 ± 0.4 vs. Y: 9.4 ± 0.6 L min⁻¹), FVC (O: 0.08 ± 0.01 vs. Y: 0.17 ± 0.02 mL/100 mL min⁻¹ mmHg⁻¹), and CVC (O: 1.29 ± 0.34 vs. Y: 1.93 ± 0.30 units mmHg⁻¹) were lower in older adults (all P < 0.01). Rapid saline infusion increased cardiac output (O: +1.9 ± 0.3, Y: +1.8 ± 0.7 L min⁻¹), FVC (O: +0.015 ± 0.007, Y: +0.048 ± 0.013 mL/100 mL min⁻¹ mmHg⁻¹), and CVC (O: +0.28 ± 0.10, Y: +0.29 ± 0.16 units mmHg⁻¹) in both groups (all P < 0.01). The absolute increase in cardiac output and CVC were similar between groups, whereas FVC increased to a greater extent in young adults (P < 0.01). These results demonstrate that healthy older adults can achieve greater levels of cutaneous vasodilatation and cardiac output during passive heating.

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