S144 Cortical spreading depression, relevance to migraine and acute brain injury in humans, and new mechanisms

Cortical spreading depression/depolarization (CSD) is a depolarization wave in cerebral gray matter that propagates across the brain at slow velocity, 2–5mm/min. For many years it was believed that CSD was an artifact produced in animal experiments and without clinical relevance. In the 1980s, brain scans of cerebral blood flow (CBF) in patients during migraine showed what was termed a 'spreading oligemia', a wave of reduced blood flow that propagated across the brain at the same rate and with the same signs of vascular impairment as CSD.

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