Publication date: Available online 25 August 2017
Source:Mutation Research/Reviews in Mutation Research
Author(s): Liliana Gómez-Flores-Ramos, Rosa María Álvarez-Gómez, Cynthia Villarreal-Garza, Talia Wegman-Ostrosky, Alejandro Mohar
Breast cancer (BC) in young women, generally defined in oncology as women who are 40 years of age or under, represents 2 out of 10 BC cases in developing countries. Several studies, including genetic cancer panel analyses, genome-wide association studies, expression analyses and polymorphism reports, have found that young women with BC exhibit a higher genetic susceptibility and specific genomic signature compared to postmenopausal women with BC. Thus, international guidelines recommend genetic counseling for this age population. This review presents our current knowledge of genetics and genomics with regards to young women with BC.
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