Physical Activity Dimensions Associated with Impaired Glucose Metabolism.

Purpose: Physical activity (PA) is important in the prevention of type 2 diabetes, yet little is known about the role of specific dimensions of PA, including sedentary time in subgroups at risk of impaired glucose metabolism (IGM). We applied a data driven decision tool to identify dimensions of PA associated with IGM across age, sex and body mass index (BMI) groups. Methods: This cross-sectional study included 1,501 individuals (mean (SD) age 65.6 (6.8) years) at high risk of type 2 diabetes from the ADDITION-PRO study. PA was measured by an individually calibrated combined accelerometer and heart rate monitor worn for 7 days. PA energy expenditure, time spent in different activity intensities, bout duration and sedentary time were considered determinants of IGM together with age, sex and BMI. Decision tree analysis was applied to identify subgroup-specific dimensions of PA associated with IGM. IGM was based on oral glucose tolerance test results and defined as fasting plasma glucose >= 6.1 mmol/L and/or 2-hour plasma glucose >= 7.8 mmol/L. Results: Among overweight (BMI >= 25kg/m2) men, accumulating less than 30 minutes/day of moderate-to-vigorous PA was associated with IGM, while in overweight women sedentary time was associated with IGM. Among individuals aged > 53 years with normal weight (BMI

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