Effects of progressive resistance training on cardiovascular autonomic regulation in patients with Parkinson`s Disease: a randomized controlled trial

Publication date: Available online 10 July 2017
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Hélcio Kanegusuku, Carla Silva-Batista, Tiago Peçanha, Alice Nieuwboer, Natan D. Silva, Luiz A.R. Costa, Marco T. de Mello, Maria E.P. Piemonte, Carlos Ugrinowitsch, Cláudia L.M. Forjaz
ObjectiveTo evaluate the effects of a progressive resistance training (RT) on cardiac autonomic modulation and on cardiovascular responses to autonomic stress tests in patients with Parkinson disease (PD).DesignRandomized clinical trial.SettingThe Brazilian Parkinson Association.Participants30 patients with PD (modified Hoehn and Yahr stages 2-3) were randomly divided into 2 groups: a progressive RT group (PDT) and a control group (PDC). In addition, a group of paired healthy control subjects without PD (HC) was evaluated.InterventionsPDT group performed 5 resistance exercises, 2 to 4 sets, 12 to 6 repetitions maximum per set. PDC group maintained their usual lifestyle.Main Outcome MeasuresPDT and PDC groups were evaluated before and after 12-weeks. HC group was evaluated once. Autonomic function was assessed by spectral analysis of heart rate (HR) variability and cardiovascular responses to autonomic stress tests (deep breathing, Valsalva maneuver and orthostatic stress).ResultsCompared with baseline, normalized low-frequency component of HR variability decreased significantly after 12 weeks in the PDT group only (PDT = 61±17 vs. 47±20 nu and PDC = 60±14 vs. 63±10 nu, interaction P<0.05). Similar result was observed for systolic blood pressure fall during orthostatic stress that also reduced only in the PDT group (PDT = -14±11 vs. -6±10 mmHg and PDC = -12±10 vs. -11±10 mmHg, interaction P<0.05). In addition, after 12 weeks, these parameters in the PDT achieved values similar to the HC group.ConclusionIn patients with PD, progressive RT improved cardiovascular autonomic dysfunction.



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