The American joint committee on cancer defines in transit (IT) metastases as any skin or subcutaneous nodule that is more than two centimetres away from the primary lesion but is not beyond the regional nodal basin. IT metastases usually present as cutaneous or subcutaneous nodules, which may or may not be pigmented. Occasionally the nodules are impalpable and are only picked up following imaging, thus making it difficult to isolate them perioperatively.
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