Response to comments on: A prospective randomized cost billing comparison of local fasciocutaneous perforator versus free Gracilis flap reconstruction for lower limb in a developing economy

Thank you for your letter and for allowing us to respond. We acknowledge that dr. Mangano et al. agree with us on the importance and relevance of the study. Regarding the first comment we present here the method we used for sample size calculation based on the flap viability outcome for each flap using the following equation n = [ (Z α/2+ Zβ)/(P1-P2)] (P1q1 + P2q2) [1], where:

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