We present a case of a female runner who presented with burning left groin and thigh pain and positional swelling following a long run. The workup revealed May-Thurner syndrome. May-Thurner syndrome anatomy is a common anatomical variant present in approximately 20% of the population. Compression of the iliac vein may result in venous stasis in the lower limb with a predisposition to deep venous thrombosis. We identify four reported cases of May-Thurner syndrome in female runners and review the importance of diagnosis and appropriate treatment of this condition.
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