Δευτέρα 19 Ιουνίου 2017

Dose-Finding Methods: Moving Away from the 3+3 to Include Richer Outcomes

The most commonly used method for dose-finding, the 3+3, has poor performances. New adaptive designs are more efficient. Nevertheless, they have reached a maximum performance level, and further improvement requires either larger sample sizes, or outcomes measures richer than the simplistic severe toxicity measured at cycle 1.



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