Cutaneous and Superficial Soft Tissue CD34(+) Spindle Cell Proliferation.

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Cutaneous and Superficial Soft Tissue CD34(+) Spindle Cell Proliferation.

Arch Pathol Lab Med. 2017 Jun 22;:

Authors: Yang H, Yu L

Abstract
CONTEXT: - Cutaneous and superficial soft tissue spindle cell proliferations with CD34 expression represent a unique heterogeneous group of lesions. They can pose diagnostic challenges for unaware pathologists in their daily practice.
OBJECTIVE: - To review selected entities of CD34(+) spindle cell proliferations in the skin and superficial soft tissue. The effective diagnostic approaches using clinical, histopathologic, and immunophenotypical findings are discussed within a broad spectrum of differential diagnosis.
DATA SOURCES: - All information used in the article is obtained from published literature by PubMed search and Internet-based search engines. The authors' collective experience and real-life examples are also used.
CONCLUSIONS: - Spindle cell proliferations with CD34 positivity can be worked up to a definitive diagnosis by using clinical, histopathologic, and immunophenotypical findings. Familiarity with these entities helps pathologists make the accurate diagnosis.

PMID: 28639855 [PubMed - as supplied by publisher]

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