Acetaminophen and ondansetron: The central serotonergic connection

Acetaminophen is one of the most widely used analgesic drugs, yet the exact mechanism of its analgesic effect remains largely unknown. Although originally thought to share similar mechanistic properties with cyclooxygenase (COX) inhibitors, acetaminophen is only weakly anti-inflammatory [1] and appears to inhibit prostaglandin synthesis centrally rather than peripherally, accounting for its antipyretic activity [2]. However, COX inhibition by acetaminophen may only occur under specific low peroxide conditions, likely explaining its known tissue selectivity [3].

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