Source:Clinical Neurology and Neurosurgery
Author(s): Gilles Allali, Magali Laidet, Stéphane Armand, Shahan Momjian, Bruno Marques, Arnaud Saj, Frédéric Assal
ObjectivesIdiopathic normal pressure hydrocephalus (iNPH) is very prevalent in aging, underdiagnosed, and represents a rare cause of reversible neurological condition. The clinical triad of iNPH − gait, cognitive and urinary symptoms – and its neuroradiological features (i.e. ventriculomegaly) are not specific and found a various neurodegenerative and/or vascular conditions. We present our iNPH standardized protocol at the Geneva University Hospitals involving a multispecialty team of behavioral neurologists, neurosurgeon, neuropsychologists, engineer, and physical therapists. Based on a pragmatic approach, the goals of this protocol is to improve the identification of older patients with iNPH from its mimics (i.e. vascular dementia or other parkinsonian syndromes).Patients and MethodsWe used a novel standardized paradigm with a simultaneous quantification of cognition and gait (dual task gait assessment and mental imagery of locomotion) before and 24hours after CSF tapping.ResultsWe assessed 125 patients with suspicion of iNPH (age: 75.9±7.4years; 34.4%female) in 5 years: 54.4% of probable/possible iNPH and 45.6% of mimics. Among the mimics, vascular dementia (24.6%) and patients with multifactorial conditions (19.9%) were the two most common diagnoses. A total of 27 patients with iNPH (39.7%) accepted the neurosurgical shunt procedure.ConclusionThis report shows that a quantified gait and cognitive assessment − using dual-task paradigms − before and after CSF tapping is feasible among older adults with suspicion of iNPH and that this multidisciplinary approach contributes to the identification of patients with iNPH from its mimics.
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