Symptoms of schizophrenia have been linked to insults during neurodevelopment such as NMDA receptor antagonist exposure. In animal models, this leads to schizophrenia-like behavioral symptoms as well as molecular and functional changes within hippocampal and prefrontal regions. The aim of this study was to determine how administration with the NMDA receptor antagonist, phencyclidine (PCP), during neurodevelopment affects functional network changes within the hippocampus and medial prefrontal cortex (mPFC). We recorded field potentials in vivo following electrical brainstem stimulation and observed a suppression of evoked theta power in ventral hippocampus, while evoked gamma power in mPFC was enhanced in rats administered neonatally with PCP. In addition, increased gamma synchrony elicited by acute administration of the NMDAR antagonist, MK-801, was exaggerated in neonatal PCP animals. These data suggests that NMDA receptor antagonist exposure during brain development alters functional networks within hippocampus and mPFC possibly contributing to the reported behavioral symptoms of this animal model of schizophrenia.
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