DNA replication and mismatch repair safeguard against metabolic imbalances [Genetics]

During DNA replication, the major DNA replicative polymerases Polδ and Polε introduce noncomplementary nucleotides approximately once in every 100,000 polymerization events. Proofreading properties of these polymerases improve their fidelity by 10- to 100-fold, and postreplicative DNA mismatch repair (MMR), which acts as a spell checker to remove mismatches that escape...

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