A Cluster RCT to Reduce Workers' Sitting Time: Impact on Cardiometabolic Biomarkers.

Purpose: To evaluate the initial and long-term impacts on cardio-metabolic health indicators of the Stand Up Victoria intervention - a 12-month, multicomponent workplace-delivered intervention that successfully reduced overall sitting time, primarily by increasing standing time. Methods: Office worksites (>=1km apart) from a single organization were cluster randomized to intervention (n=7) or control (n=7). Participants were 136 intervention and 95 control desk-based workers (5-39 per worksite; 68% women; mean+/-SD age = 45.6+/-9.4 years). Outcomes, assessed at baseline (0 months), three months, and 12 months, were 14 individual biomarkers of body composition, blood pressure, glucose metabolism, lipid metabolism and a composite overall cardio-metabolic risk score. Intervention effects were assessed by linear mixed models, accounting for repeated measures and clustering, baseline values and potential confounders. Missing data were multiply imputed. Significance was set at p

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