Changes in peripheral blood cytokine contents in behaviorally passive and active Wistar rats were assessed at different time points after acute stressing using a restraint model during the dark part of the day. In passive animals, decreases in the concentrations of most of the pro- and anti-inflammatory cytokines studied were most marked immediately and particularly three days after stress. Changes in the cytokine profile of the blood following experimental stress were less marked in behaviorally active individuals: significant decreases from normal were seen only for the proinflammatory cytokine IL-1α and the anti-inflammatory cytokines IL-4 and IL-13. In contrast to passive rats, these changes were more marked in active individuals one day after negative emotional loading. These data illustrate the specific features of the involvement of immunoactive substances in the system controlling the physiological functions and forming individual resistance to the negative sequelae of stress.
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