COMPARISON OF A SINGLE SYRINGE MIXTURE OF KETAMINE AND PROPOFOL (KETOFOL) AND PROPOFOL AS AN ANESTHETIC AGENT IN DIRECT LARYNGEAL BIOPSY PROCEDURE

2016-12-10T00-22-31Z
Source: Indo American Journal of Pharmaceutical Research
Dr. Kinna Shah, Dr. B.M Patel.
Aim: To evaluate the effect of ketofol on haemodynamic response and recovery parameters and to compare it with Propofol in direct laryngoscopic examination /biopsy (DLBX). Method: Three hundred fifteen patients posted for DLB were allocated in this prospective double blind study. Patients were randomly assigned to either Group KP (Ketamine 50 mg +Propofol 100mg in 10 cc) or Group P (100 mg in 10 cc).Inj. Succinylcholine 1mg/kg given in all patients. Pulse, BP and Spo2 were noted at 0, 1, 3, 5, 7 minutes and after every 15 minutes interval up to discharge. Total volume of drug used and Ramsay sedation scale in each procedure was noted. Results: Time to eye opening was earlier in Group KP (10.56+/-4.22v/s 15.82+/-5.66 P value

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