Non-harmonicity in high-frequency components of the intra-operative corticogram to delineate epileptogenic tissue during surgery

Epilepsy is a dynamic condition as seizures occur intermittently and in most cases unexpectedly. This suggests that the underlying processes responsible for the generation and cessation of seizures are non-harmonic, i.e. non-linear and non-stationary. A high level of non-linearity in the system is needed to initiate seizures (Helling et al., 2015). The epileptiform EEG contains several biomarkers which all have a strong non-linear component (Elger et al., 2000; Andrzejak et al., 2012). This holds true for epileptiform inter-ictal spikes, for the recently discovered high-frequency oscillations (HFOs; >80 Hz) and for seizures themselves.

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