Electrophysiology in Fisher syndrome

Fisher's syndrome (FS) is defined by the unique clinical triad of ophthalmoplegia, ataxia, and areflexia (Fisher, 1956). This syndrome is regarded as a variant of Guillain-Barré syndrome (GBS) and is mediated by autoantibodies against ganglioside GQ1b (Mori and Kuwabara, 2011; Shahrizaila and Yuki, 2012). In his original report, Charles Miller Fisher himself speculated that a selective attack on the sensory neurons underlying postural stability should have existed and that the involvement of special sensory neurons mediating tendon reflexes should be considered (Fisher, 1956).

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