An insight into the genotoxicity assessment studies in dipterans

Publication date: Available online 13 October 2016
Source:Mutation Research/Reviews in Mutation Research
Author(s): Nidhi Mishra, Rashmi Srivastava, Uma Rani Agrawal, Raghav Ram Tewari
The dipterans have been widely utilized in genotoxicity assessment studies. Short life span, easy maintenance, production of large number of offspring in a single generation and the tissues with appropriate cell populations make these flies ideal for studies associated to developmental biology, diseases, genetics, genetic toxicology and stress biology in the group. Moreover, their cosmopolitan presence makes them suitable candidate for ecological bio-monitoring. An attempt has been made in the present review to reveal the significance of dipteran flies for assessing alterations in genetic content through various genotoxicity biomarkers and to summarize the gradual advancement in these studies. Recent studies on genotoxicity assays in dipterans have opened up a broader perspective for DNA repair related mechanistic studies, pre-screening of chemicals and environmental bio-monitoring. Studies in dipterans, other than Drosophila may be helpful in using them as an alternative model system for assessment of genotoxicity, especially at the gene level and further extension of these studies give a future insight to develop new strategies for maintaining environment friendly limits of the toxicants.



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