Repeated Prolonged Exercise Decreases Maximal Fat Oxidation in Older Men.

Introduction/Purpose: Fat metabolism and muscle adaptation was investigated in 6 older trained men (age: 61 +/- 4 years; VO2max: 48 +/- 2 mL kg-1 min-1) following repeated prolonged exercise). Methods: 2706 km (1,681 miles) cycling was performed over 14 days and a blood sample and a muscle biopsy were obtained at rest after an overnight fast before and 30 hours after the completion of the cycling. VO2-max and maximal fat oxidation were measured using incremental exercise tests. Heart rate was continuously sampled during cycling to estimate exercise intensity. Results: The daily duration of exercise was 10 hours and 31 +/- 37 min and the mean intensity was 53 +/- 1 % of VO2max. Body weight remained unchanged. VO2max and maximal fat oxidation rate decreased by 6 +/- 2 % (P = 0.04) and 32 +/- 8 % (P

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