Evaluation of Anti-epileptic activity of Leaf extracts of Punica granatum on experimental models of epilepsy in mice

2016-09-21T13-13-14Z
Source: Journal of Intercultural Ethnopharmacology
Gollapalle L Viswanatha, Marikunte V Venkataranganna, NBL Prasad Prasad, Godavarthi Ashok.
Aims: This study was aimed to examine the anti-epileptic activity of leaf extracts of Punica granatum in experimental models of epilepsy in swiss albino mice. Methods: Petroleum ether (PLPG), methanolic (MLPG) and aqueous (ALPG) extracts of Punica granatum leaves were initially evaluated against 6-Hz-induced seizure model, the potent extract was further evaluated against maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Further, the potent extractwas evaluated for itsinfluence on Gamma amino butyric acid (GABA) levels in brain, to explore the possible mechanism of action. In addition, the potent extract was subjected to actophotometer test to assess its possible locomotor activity deficit inducing action. Results: In6-Hz seizure test, the MLPG has alleviated 6-Hz-induced seizures significantly and dose dependently at doses 50, 100, 200 and 400 mg/kg. In contrast, PLPG and ALPG did not show any protection, only high dose of ALPG (400 and 800 mg/kg, p.o.) showed very slight inhibition. Based on these observations only MLPG was tested in MES and PTZ models. Interestingly, the MLPG (50, 100, 200 and 400 mg/kg) has offered significant and dose dependent protection against MES (P


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