Chronic cholestasis in a patient with sickle-cell anemia: Histological findings

A 22-year-old Senegalese man with sickle-cell anaemia (SCA; HbS/HbS) was referred to Hepatology department because of cholestasis [AST 82U/l, ALT 41U/l, ALP 241U/l, gGT 135U/l, bilirubin 8.1 (3.7) mg/dl]; liver function tests were preserved. He was asymptomatic, denied any alcohol or drug intake. Common causes of chronic liver disease were excluded: he was negative for anti-HCV, HBsAg and autoimmune hepatitis markers; copper and iron overload were also excluded. A hard liver was appreciable at the umbilical line, without splenomegaly or decompensation signs.

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