Evaluation of hypolipidemic effect of Tinospora cordifolia in cholesterol diet induced hyperlipidemia in rats

2016-07-07T07-14-53Z
Source: International Journal of Basic & Clinical Pharmacology
Sparshadeep E. M., Roopa P. Nayak, Kavana G. V., Mohandas Rai.
Background: There is always a need for developing novel drugs with higher efficacy and fewer side effects. Though statins are generally well-tolerated drugs for hyperlipidemia with high efficacy they are not free from adverse effects. Herbal drugs are well known for their cost-effectiveness and minimal side effects. Tinospora cordifolia (T. cordifolia) is one such plant with known hypolipidemic activity and wide availability in India. Hence this study is an attempt to verify and evaluate the extent of efficacy of T. cordifolia as a hypolipidemic agent. The objective of the study is to compare the hypolipidemic activity of aqueous root extract of T. cordifolia with that of Rosuvastatin in cholesterol diet-induced hyperlipidemia in rats. Methods: Hyperlipidemia was induced in male albino rats of wistar strain in the first 30 days of feeding period and continued in the next 30 days of treatment period. Aqueous root extract of T. cordifolia (2.5 and 5g/kg, per oral) was administered as test drug in the treatment period. Rosuvastatin (10 mg/kg, per oral) was used as the standard drug. Serum lipid profile, atherogenic index and body weights were estimated for all rats on the day before the start of the feeding period and on day 0, 15 and 30 of the treatment period. The results were analyzed statistically using students unpaired and paired t-test wherever applicable. Results: Serum lipid levels showed significant reduction (p


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