A double blinded comparative study of oral premedication in children with midazolam alone or in combination with ketamine

2016-07-11T04-52-25Z
Source: International Journal of Contemporary Pediatrics
Jyoti Magar, Manish B. Kotwani, Suhas Kotak.
Background: Surgery and anaesthesia induction cause considerable emotional stress upon children. In children pre-anaesthetic medications are frequently administered as pharmacological adjunction to alleviate the stress and fear of surgery as well as to ease child-parent separation and promote a smooth induction of anaesthesia. Methods: Prospective double blinded randomized comparative study of oral premedication in children with midazolam alone or combination of midazolam with low dose ketamine in the age group of 3-10 years undergoing surgical procedures under standardized general anesthesia. Results: In group M success rate of satisfactory sedation was 68.99% as against 76.59% in group MK, whereas success rate of anxiolysis was 80.00% in group M compared to 93.33% in group MK. 93.32% children were easily separated from parents in M Group compared to 96.66% in MK group. Also 73.32% children co-operated for IV line insertion in M group as against 96.66% in group MK and 83.33% children showed better mask acceptance in M group compared to 93.33% in MK group. Conclusions: From present study, it was concluded that addition of low dose of ketamine improves quality and success rate of satisfactory sedation, anxiolysis, parental separation, co-operation for IV line and mask acceptance.


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