Objectives: We aimed to study whether the incidence of pediatric celiac disease (CD) in South-Eastern Norway changed from 2000-2010. We also examined if there was a change in symptoms and histopathological morphology in the duodenal biopsies during the same period. Methods: In three hospitals in South-Eastern Norway, records from pediatric patients (0-14.9 years) diagnosed with CD during two three-year periods (2000-2002 and 2008-2010) were reviewed. Only cases with a duodenal biopsy diagnosis of CD classified, as Marsh grade 2 and 3a-c were included. Frequencies of symptoms, anthropometric data and laboratory results were compared, in addition to re-examinations of histological sections from one of the hospitals. Results: A total number of 400 cases were diagnosed with a female:male ratio of 1.5:1. The incidence rate for 2000-2002 was 15.9 cases per 100 000 person-years (95% CI 12.8-19.4), compared to 45.5 cases per 100 000 person-years during 2008-2010 (95% CI 40.5-50.9), p
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