Physical Activity and Risk of Lung Cancer: A Meta-analysis

Objective: Previous studies concerning the association between physical activity (PA) and risk of lung cancer yielded mixed results. We investigated the association by performing a meta-analysis. Data Sources: Relevant studies were identified by searching PubMed and EMBASE to January 2014. Twelve cohort studies and 6 case–control studies involving 2 468 470 participants and 26 453 cases of lung cancer were selected for meta-analysis. Main Results: We calculated the summary relative risk (RR) and 95% confidence intervals (CIs) using random-effects models. The analyses showed that individuals who participated in any amount of PA had an RR of 0.79 (95% CI, 0.73-0.86) for risk of lung cancer. Those who participated in high PA (vs low PA) had an RR of 0.75 (95% CI, 0.68-0.84). Stratifying by study design (case–control and cohort studies), smoking status (current, former, and never smokers), and gender, similar inverse associations were found for all the subgroups except for never smokers subgroup. Conclusions: Pooled results from observational studies support a protective effect of PA against lung cancer.

from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/1SUHQuw
via IFTTT