Biomechanical Factors Associate with Pain and Symptoms Following Anterior Cruciate Ligament Injury and Reconstruction

Few studies have investigated associations between patients reported outcome and gait in subjects with Anterior cruciate ligament(ACL) injury and reconstruction over time. As there is an association between ACL rupture and the presence of osteoarthritis later in life a better understanding of these relationships will help elucidate how subjects' gait pattern may affect pain and symptoms, potentially leading to better treatment or preventing the development of knee OA.

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Immediate and Short-Term Effects of Kinesio Taping Tightness in Mechanical Low Back Pain: A Randomized Controlled Trial.

There is controversy regarding Kinesio® Tex taping (KT) best technique of application, and the theory supporting that skin convolutions may explain its efficacy has been recently challenged.

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Targeting Small Bowel Receptors to Treat Constipation and Diarrhea

Abstract

Background

The options for the treatment of diarrhea and constipation are evolving as emerging therapies target small bowel receptors. The goal of this review is to discuss small bowel receptors involved in intestinal absorption, secretion, and motility. The review highlights therapies already approved or currently being studied for the modulation of these receptors.

Methods

The articles cited in this review focus on the molecular level of pathways involved in diarrhea and constipation, and highlight the respective pharmacotherapies.

Results

The majority of the studies in the current literature investigate the effects of both the small and large intestine receptors on diarrhea and constipation. There are fewer studies that isolate the effects of these receptors solely on the small bowel, and focusing more on the receptors found distinctly in the small intestine may be an area of interest for future studies as this can inspire more targeted therapies.

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Derivation and validation of the prediabetes self-assessment screening score after acute pancreatitis (PERSEUS)

Approximately 40% of patients develop abnormal glucose metabolism after a single episode of acute pancreatitis. This study aimed to develop and validate a prediabetes self-assessment screening score for patients after acute pancreatitis.

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ERCP and Laparoscopic cholecystectomy in a patient with situs inversus totalis

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Economic burden of diverticular disease: an observational analysis based on real world data from an italian region

Diverticular disease (DD), a herniation of the colonic mucosa through the muscle layer, covers a wide variety of conditions associated with the presence of diverticula in the colon. The most serious form is an acute episode of diverticulitis, which can lead to hospitalization and surgery with various types of consequences. The main aim of this study is to evaluate the economic burden of hospitalizations arising from acute episodes of diverticulitis using data from the administrative databases used in the Marche region in Italy and, as a secondary objective of this real-world data analysis, to study patient outcome variables following initial hospitalization for diverticulitis.

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Pupil size as a measure of within-task learning

Abstract

Pupillometry is commonly used in research to determine how much mental effort an individual is exerting while completing tasks. Traditionally, larger pupils are associated with increased mental effort when completing more difficult tasks. However, little research has investigated how pupils change as individuals learn a new task. In theory, as one repeatedly completes a task, the task demands should reduce, reliance on working memory should decrease, and the task should become more automatic. This should translate to faster completion times and smaller peak pupil dilations. We tested this hypothesis by having participants complete multiple trials of a cognitive task that requires individuals to orient themselves in space relative to a target. We found that trial completion times and maximum pupil size significantly reduced across trials. These data suggest that measuring changes in pupil dilation may help researchers determine whether individuals have shifted from a learned procedure to an automatic processing of information when learning a new task.

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