Aerophagia and Abdomino-phrenic Dyssynergia in a 3-year-old.

No abstract available

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Functional Neuroimaging in IBS, A Brain Twister.

No abstract available

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How Secure is the Diagnosis of Ulcerative Colitis in Children, Even After Colectomy?.

Objectives: We reviewed all children who have undergone a colectomy for ulcerative colitis in our tertiary referral centre in a twelve-year period to assess the rate of reclassification as Crohn's disease. In contrast to Crohn's Disease, a colectomy is considered to be definitive treatment for patients with ulcerative colitis. Distinguishing between the two can be challenging when disease is manifest only within the colon - even histological examination of a colectomy specimen may be inconclusive. Historically, the recognised 'rediagnosis' rate (post colectomy) was reported at around 3-7%. A recent study suggested that a higher rate of 13% should be expected in children. This has implications in terms of pre-operative counselling and surgical decision making. Methods: A retrospective case-note review of all patients who underwent a colectomy for ulcerative colitis between 2003 and 2014 in a single paediatric tertiary referral centre was performed. Results: Of the 570 children diagnosed with inflammatory bowel disease in this period, 190 were diagnosed as ulcerative colitis. Of these 190 cases, 29 underwent a colectomy. None of these was re-classified following histological examination of the colectomy sample. Seven out of the 29 patients (24%) were subsequently diagnosed with Crohn's disease (median follow-up 7.6 years). This is significantly higher than previously reported rates (p = 0.003). Conclusions: Our data suggests that later manifestation of Crohn's disease is more common than previously thought (24%). Therefore, a diagnosis of ulcerative colitis in children should be regarded as provisional and a potential later diagnosis of Crohn's disease taken into account when considering colectomy and J-pouch formation. (C) 2017 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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Reply to “Need for updating safety recommendations on repetitive transcranial magnetic stimulation in stroke patients”

Publication date: Available online 3 June 2017
Source:Clinical Neurophysiology
Author(s): Ela B. Plow, Vishwanath Sankarasubramanian, Kelsey A. Potter-Baker, Yin-Liang Lin




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Need for updating safety recommendations on repetitive transcranial magnetic stimulation in stroke patients

Publication date: Available online 3 June 2017
Source:Clinical Neurophysiology
Author(s): Bertrand Glize, Dominique Guehl, Mélanie Cogné




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Editorial Board

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Particulate matter air pollution: individual choices for improving cardiometabolic well-being

Abstract

Exposure to small particulate matter (PM_2.5) has become the 5th highest ranking risk factor for death, responsible for 4.2 million deaths worldwide. PM pollution is also associated with cardiovascular disease and type 2 diabetes, and may contribute to deteriorate the already poor cardiometabolic outlook of the diabetic patient. Although most sources of outdoor air pollution are well beyond the control of individuals, there is still room for personal action. Health behaviors (smoking cessation, avoiding obesity, and increasing physical activity) may increase the poor life expectancy of individuals in the lowest income quartile of the Western population; moreover, a favorable lifestyle, (no current smoking, no obesity, physical activity at least once weekly, and a healthy diet pattern), may cut by nearly 50% the risk of coronary heart disease among people at high genetic risk. Things seem not immutable, as individual healthy choices do matter.

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