Duplicated distal phalanx of thumb or hallux in trisomy 13: A recurrent feature in a series of 42 fetuses

American Journal of Medical Genetics Part A, EarlyView.


from Genetics via xlomafota13 on Inoreader https://ift.tt/2RTU8Zn
via IFTTT

Personalised medicine and population health: breast and ovarian cancer

Abstract

It has been suggested that a personalised approach to cancer prevention and screening might lead to a new paradigm for cancer control. Various aspects include testing for high-penetrance cancer susceptibility genes and generating personal risks scores, based on panels of single nucleotide polymorphisms. These tests can categorize women into various groupings of risk for cancer prevention (surgery and chemoprevention) cancer screening and prevention of cancer recurrence. In this review, I investigate various claims and come to the conclusion that the approach may be beneficial for the occasional patient but is unlikely to have any impact on reducing the burden of cancer incidence and mortality as whole. Challenges include meeting a high uptake of the test in the population, developing an effective and acceptable intervention and the willingness of healthy women to follow health care provider recommendations. The review focuses on strategies to reduce mortality from breast and ovarian cancer but is potentially applicable to other cancer sites, such as colon, prostate, and endometrial.

from Genetics via xlomafota13 on Inoreader https://ift.tt/2EmW4H0
via IFTTT

Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


from Physiology via xlomafota13 on Inoreader https://ift.tt/2J13uyt
via IFTTT

Development Of The Cerebral Cortex And The Effect Of The Intrauterine Environment

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


from Physiology via xlomafota13 on Inoreader https://ift.tt/2OrnQqx
via IFTTT

Exercise training reduces the insulin‐sensitizing effect of acute exercise in human skeletal muscle

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


from Physiology via xlomafota13 on Inoreader https://ift.tt/2J0aonq
via IFTTT

Baroreflex functionality in the eye of diffusion tensor imaging

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


from Physiology via xlomafota13 on Inoreader https://ift.tt/2OrnOPr
via IFTTT

RAAS inhibitors directly reduce diabetes‐induced Renal fibrosis via PDGF and CTGF inhibition

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


from Physiology via xlomafota13 on Inoreader https://ift.tt/2J2oftt
via IFTTT