Deficiency of the BMP Type I receptor ALK3 partly protects mice from anemia of inflammation

Inflammatory stimuli induce the hepatic iron regulatory hormone hepcidin, which contributes to anaemia of inflammation (AI). Hepcidin expression is regulated by the bone morphogenetic protein (BMP) and the int...

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Bony ingrowth potential of 3D printed porous titanium alloy: a direct comparison of interbody cage materials in an in vivo ovine lumbar fusion model

There is significant variability in the materials commonly used for interbody cages in spine surgery. It is theorized that 3-D printed interbody cages utilizing porous titanium material can provide more consistent bone ingrowth and biological fixation.

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A novel anterior decompression technique (vertebral body sliding osteotomy) for ossification of posterior longitudinal ligament of the cervical spine

Conventional anterior decompression surgery for cervical myelopathy, including anterior corpectomy and fusion, is technically demanding and known to be associated with a higher incidence of surgery-related complications, including cerebrospinal fluid (CSF) leakage, neurologic deterioration, and graft failure compared with posterior surgery.

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Clinical outcomes of percutaneous suction aspiration and drainage for the treatment of infective spondylodiscitis with paravertebral and/or epidural abscess

Patients with infective spondylodiscitis who failed conservative treatment are generally indicated for open surgery. However, some patients are poor candidates for standard surgery, hence the need to evaluate less invasive approaches. Good outcomes were previously reported for percutaneous suction aspiration and drainage (PSAD) in the treatment of infective spondylodiscitis resistant to conservative therapy. We recently extended the surgical approach of PSAD to allow drainage of paravertebral or epidural abscesses in patients with progressive infective spondylodiscitis.

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The in vivo response to a novel ti coating compared to PEEK: evaluation of the periphery and inner surfaces of an implant

Context: Increasing bone ongrowth and ingrowth of PEEK interbody fusion devices has the potential to improve clinical outcomes.

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Variation in costs among surgeons for lumbar spinal stenosis

Lumbar spinal stenosis is a common condition in the elderly for which costs vary substantially by region. Comparing differences between surgeons from a single institution, thereby omitting regional variation, could aid in identifying factors associated with higher costs and individual drivers of costs. The use of decision aids (DAs) has been suggested as one of the possible tools for diminishing costs and cost variation.

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Comparing spiking and slow wave activity from invasive electroencephalography in patients with and without seizures

Seizures have long been defined as paroxysmal events typified by abnormally excessive or synchronous brain activity (Fisher et al., 2005). Seizures can occur in healthy brain, or can be the result of disease. By definition, epilepsy requires an increased probability of seizures. Seizure threshold is a clinically useful concept expressing a time-varying probability of seizures. Despite clinical relevance, there remains no clear way of quantitatively assessing seizure probability. As a result, epilepsy patients often undergo long therapy titrations or never have their therapy appropriately optimized.

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