HEPACONTROL. A program that reduces early readmissions, mortality at 60 days, and healthcare costs in decompensated cirrhosis

Decompensated cirrhosis patients have an elevated incidence of early readmission, mortality and economic burden. The aims of HEPACONTROL were to reduce early readmission and to evaluate its impact on mortality and emergency department visits.

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HEPACONTROL. A program that reduces early readmissions, mortality at 60 days, and healthcare costs in decompensated cirrhosis

Decompensated cirrhosis patients have an elevated incidence of early readmission, mortality and economic burden. The aims of HEPACONTROL were to reduce early readmission and to evaluate its impact on mortality and emergency department visits.

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FERM domain phosphorylation and endogenous 3′UTR are not essential for regulating the function and subcellular localization of polarity protein Crumbs

Publication date: Available online 12 August 2017
Source:Journal of Genetics and Genomics
Author(s): Haowei Cao, Rui Xu, Qiping Shi, Dandan Zhang, Juan Huang, Yang Hong




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Efficient generation of the mouse model with a defined point mutation through haploid cell-mediated gene-editing

Publication date: Available online 12 August 2017
Source:Journal of Genetics and Genomics
Author(s): Leixin Wei, Xiukun Wang, Suming Yang, Wen Yuan, Jinsong Li




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Liver transplantation for NASH cirrhosis is not performed at the expense of major post-operative morbidity

Non-alcoholic steatohepatitis (NASH) is an emerging indication for liver transplantation (LT) and coexists with multiple comorbidities. Obese and cirrhotic patients experience more perioperative complications. Limited data exist about short-term complications after LT for NASH cirrhosis.

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Fibroblast Growth Factor 15 Deficiency Increases Susceptibility but does not Improves Repair to Acetaminophen-induced Liver Injury in Mice

The leading cause of acute liver failure (ALF) is hepatotoxicity from acetaminophen (APAP) overdose. However, limited options are available to treat this ALF so stimulating liver regeneration maybe a potential treatment. Our previous study has shown that fibroblast growth factor 15 (FGF15) plays a crucial role in liver regeneration, but the roles of FGF15 in liver injury and repair following APAP-overdose are unknown. In this study, treatment of FGF15 knockout (KO) male mice with APAP at 200, 250, or 300mg/kg significantly increased the degree of liver injury compared to wild type (WT) mice.

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Community Use of Physical and Occupational Therapy After Stroke and Risk of Hospital Readmission

Publication date: Available online 12 August 2017
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Janet K. Freburger, Dongmei Li, Erin P. Fraher
ObjectivesTo determine whether receipt of therapy and number and timing of therapy visits decreased hospital readmission risk in stroke survivors discharged home.DesignRetrospective cohort analysis of Medicare claims (2010-2013).SettingAcute care hospital and community.ParticipantsPatients hospitalized for stroke who were discharged home and survived the first 30 days (N=23,413; mean [SD] age of 77.6 [7.5] years).InterventionsPhysical and occupational therapist use in the home and/or outpatient setting in the first 30 days after discharge (any use, number of visits, days to first visit).Main Outcome MeasureHospital readmission 30-60 days after discharge. Covariates included demographic characteristics, proxy variables for functional status, hospitalization characteristics, comorbidities, and prior health care use. Multivariate logistic regression analyses were conducted to examine the relationship between therapist use and readmission.ResultsDuring the first 30 days after discharge, 31% of patients saw a therapist in the home, 11% saw a therapist in an outpatient setting, and 59% did not see a therapist. Relative to patients who had no therapist contact, those who saw an outpatient therapist were less likely to be readmitted to the hospital (odds ratio 0.73 [059-0.90]). While the point estimates did not reach statistical significance, there was some suggestion that the greater the number of therapist visits in the home and the sooner the visits started, the lower the risk of hospital readmission.ConclusionAfter controlling for observable demographic, clinical, and health-related differences, we found that individuals who received outpatient therapy in the first 30 days after discharge home following stroke were less likely to be readmitted to the hospital in the subsequent 30 days, relative to those who received no therapy.



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