Τρίτη 1 Νοεμβρίου 2016
Effects of the transcatheter closure of atrial septal defect on electrocardiographic and echocardiographic parameters six months after the closure
2016-11-01T07-05-05Z
Source: Medicine Science | International Medical Journal
Halil Atas, Mehmet Cansel, Ertugrul Kurtoglu, Hasan Pekdemir, Ramazan Ozdemir.
Although percutaneous transcatheter atrial septal defect (ASD) closure (TCC) has been performed on adults for a long time there is limited data about the effects of the procedure in the literature and the majority of studies have been performed on children. The study purposed to evaluate the impact of TCC on cardiac remodeling, electrical changes and exercise capacity in adults. Transthoracic echocardiography and electrocardiography were performed one day before and six months after TCC in 27 consecutive patients who underwent successful TCC. Twenty-seven age and sex matched healthy subjects were used as control group. Right ventricular (RV) diameter (had decreased from 44±6.3 to 34±3.9; p
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Impact of vesicular glutamate leakage on synaptic transmission at the calyx of Held
Abstract
Glutamate leaks out of synaptic vesicles when trans-vesicular proton gradient is dissipated in isolated vesicle preparations. In the nerve terminal, however, it is controversial whether glutamate can leak out of vesicles. To address this issue, we abolished vesicular glutamate uptake by washing out presynaptic cytosolic glutamate in whole-cell dialysis, or by blocking vacuolar ATPase using bafilomycin A1 (Baf), at the calyx of Held in mice brainstem slices. Presynaptic glutamate washout or Baf application reduced the mean amplitude and frequency of spontaneous miniature (m) EPSCs and mean amplitude of EPSCs evoked every 10 min. The percentage reduction of mEPSC amplitude was much less than that of EPSC amplitude or mEPSC frequency, and tended to reach a plateau. The mean amplitude of mEPSCs after glutamate washout or Baf application remained high above the detection limit, deduced from the reduction of mEPSC amplitude by the AMPA receptor blocker CNQX. Membrane capacitance measurements from presynaptic terminals indicated no effect of glutamate washout on exocytosis or endocytosis of synaptic vesicles. We conclude that glutamate can leak out of vesicles unless it is continuously taken up from presynaptic cytosol. However, the magnitude of glutamate leakage was small and had only a minor effect on synaptic responses. By contrast, prominent rundowns of EPSC amplitude and mEPSC frequency observed after glutamate washout or Baf application are likely caused by accumulation of unfilled vesicles in presynaptic terminals retrieved after spontaneous and evoked glutamate release.
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Effect of Dental Chair Light on Enamel Bonding of Orthodontic Brackets Using Light Cure Based Adhesive System: An In-Vitro Study
2016-10-31T23-36-36Z
Source: Acta Informatica Medica
Anil Tiwari, Tarulatha Shyagali, Sarvraj Kohli, Rishi Joshi, Abhishek Gupta, and Rana Tiwari.
Aim: The aim of this in vitro study was to evaluate the influence of the Dental chair light on the bond strength of light cured composite resin. Materials and Methods: Sixty therapeutically extracted human premolar teeth were randomly allocated to two groups of 30 specimens each. In both groups light cured composite resin (Transbond XT) and MBT premolar metal brackets (3M Unitek) was used to bond brackets. In group I and II light curing was done using Light-emitting diode light curing units without and with the dental chair light respectively. After bonding, all samples were stored in distilled water at room temperature for 24 hours and subsequently tested for shear bond strength and Adhesive Remnant Index (ARI) scores. Data was subjected to Mann Whitney U statistical test. Results: Results indicated that there was significantly higher shear bond strength (7.71 ± 1.90) for the Group II (composite cured with LED and dental chair light ) compared with Group I (composite cured with LED LCU only) (5.74 ± 1.13).the obtained difference was statistically significant. There was no statistical significant difference between ARI scores in between the groups. Conclusions: light cure bonding with dental chair light switched on will produce greater bond strength than the conventional bonding. However, the ARI score were similar to both the groups. It is advised that the inexperienced orthodontist should always switch off the dental chair light while bonding for enough working time during the bracket placement.
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Role of Endothelial Cell Function Assessment Using Flow-mediated Dilation for Diagnosing Coronary Artery Disease in Low-risk Patients
2016-10-31T23-36-36Z
Source: Acta Informatica Medica
Seyed Mahmoud Nouraei, Ali Ghaemian,Hanieh Shiraj,Reza Ali Mohammadpour, and Alireza Malekrah.
Introduction: Flow-mediated dilation (FMD) measurement in the brachial artery (BA) is a method of endothelial cell function assessment. We can use it to predict atherosclerotic coronary artery disease. We investigated the predictive value of FMD for the presence of coronary artery disease (CAD) in a low-risk population of patients without major (CAD) risk factors. Materials and Methods: Three hundred and ninety-seven patients (age 53.2±9 years; 194 men) with chest pain admitted for coronary angiography were enrolled in this study. FMD was measured in the BA before coronary angiography using high-resolution ultrasound. Results: Coronary angiography was normal in (151)patient, (149) with single and (97) multi-vessel disease. FMD was significantly higher in normal coronary groupagainst patients with coronary artery disease (11.1±2.6% vs. 6.8±3.1%; P
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Designing and Implementation of Retina Image Drawing System and Automatic Report Generation from Retina Examinations
2016-10-31T23-36-36Z
Source: Acta Informatica Medica
Reza Safdari, Mehrshad Mokhtaran, Shahram Tahmasebian.
Introduction: Electronic medical records as one of major parts of electronic health records is an important application of Medical Informatics. EMR includes different types of data, Graphical items being one of these data types. To this end, a standard structure for storing and recovering and finally exchanging this data type is required. In order to standardize information items in this research, UMLS standard is used. In this research, graphical information from fondues designing in retina surgery forms is used for the task of implementation. Implementation: Three-layer software architecture is used for implementation of this system, which includes user interface, data base access and business logic. XML database is used for storing and exchanging of data. User interface is designed by the means of Adobe Flash. Also in the user interface for eye examinations, appropriate icons compatible with current pathologies in retina examinations are considered and UMLS codes are used for standardizations purposes. Results: As this project is independently implemented in Adobe Flash, it can be run in most of electronic patient records software. For evaluation purposes of this research, an EMR system for eye clinics is used. Tree structure is used for data entry and finally a text report based on the entered data will be generated. By storing graphical items in this software editing and searching in medical concepts and also comparing features will be available. Conclusion: One of the data items that we encounter in various medical records is graphical data. In order to cover the patient's complete electronic medical records, the Electronic Implementation of this information is important. For this purpose, graphical items in retina surgery forms were used and finally a software application for drawing retina picture was developed. Also, XML files were used for the purpose of storing valuable medical data from the pictures, and also UMLS were applied for the standardization purpose. The developed software is currently being used in some of eye clinics in Iran.
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