Nature Reviews Genetics. doi:10.1038/nrg.2016.134
Authors: Cameron P. Bracken, Hamish S. Scott & Gregory J. Goodall
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Δευτέρα 31 Οκτωβρίου 2016
A network-biology perspective of microRNA function and dysfunction in cancer
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Non-coding RNA: Deciphering the rules of microRNA targeting
Nature Reviews Genetics. doi:10.1038/nrg.2016.148
Author: Ross Cloney
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Loss-of-function genetic tools for animal models: cross-species and cross-platform differences
Nature Reviews Genetics. doi:10.1038/nrg.2016.118
Authors: Benjamin E. Housden, Matthias Muhar, Matthew Gemberling, Charles A. Gersbach, Didier Y. R. Stainier, Geraldine Seydoux, Stephanie E. Mohr, Johannes Zuber & Norbert Perrimon
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Organization and function of the 3D genome
Nature Reviews Genetics. doi:10.1038/nrg.2016.147
Author: Boyan Bonev & Giacomo Cavalli
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Genomics: Mapping meiotic breaks
Nature Reviews Genetics. doi:10.1038/nrg.2016.146
Author: Ross Cloney
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Κυριακή 30 Οκτωβρίου 2016
Loss-of-function genetic tools for animal models: cross-species and cross-platform differences
Loss-of-function (LOF) approaches are powerful experimental tools for characterizing gene functions. However, emerging discrepancies when genes are investigated using different tools or organisms has triggered debate about how such LOF results should be biologically interpreted. In this Review, experts from varied fields discuss how understanding the underlying features of each LOF approach can provide explanations for different experimental outcomes and can guide their optimal and reliable application.
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