Histopathological study of Round Cell tumors - A retrospective study

2016-10-19T22-45-34Z
Source: International Journal of Medical Science and Public Health
Ravi G Patel, Pooja Y Shah, Shridhan G Prajapati, Nirali S Amin, Varsha S Khant.
Background: Round Cell Tumors are heterogeneous malignancy featuring primitive undifferentiated small cell morphology. Small round cell tumors mostly occur in children, adolescents, and young adults. Because of their significant morphological overlap, have become a paradigm for an integrated approach to diagnosis. Immunohistochemistry (IHC) is the most common ancillary technique used for differential diagnosis of round cell tumors. Finding from all these studies are reviewed and interpreted in respect with clinical history, laboratory investigations, and diagnostic imaging finding. Objectives: (i) To study the incidence, and age vs. sex wise distribution of round cell tumors. (ii) To study the Immunohistochemical (IHC) pattern of these different round cell tumors and correlate the morphological diagnosis with IHC to determine its role as a confirmatory or diagnostic marker of the round cell tumors. Materials and Methods: As a part of study 75 (seventy-five) cases were selected during the year 2013-2015. Relevant findings were obtained. Biopsy tissues/ samples were fixed, paraffin embedded, sectioned and, stained with hematoxylin and eosin. IHC was performed on each case. Results were analyzed and compared. Results: Out of 75 cases, there were 22 cases (29.33%) of Non-Hodgkins lymphoma with the highest incidence. According to age wise distribution, the highest incidence was observed in 0-10 years of age group. According to sex wise distribution, a higher incidence was observed in males. There were 50 cases (66.66 %) of Males and 25 cases (33.33%) of Females. Overall M:F ratio was 2:1. Based on IHC, 22 cases of NHL were further classified into Burkitts lymphoma, Lymphoblastic lymphoma, and Diffuse Large B-cell lymphoma. IHC study of PNET and Rhabdomyosarcoma showed CD 99(86.7%), NSE(73.3%) and Vimentin(100%) positivity and Desmin, Actin, CD 99 and Vimentin positivity respectively. IHC study of Neuroblastoma and medulloblastoma showed NSE, NF, Chromogranin, S 100 and Synaptophysin positivity and GFAP, Synaptophysin, Vimentin, and Ki67 positivity respectively. Conclusion: Most frequent Round Cell Tumors are Non-Hodgkins Lymphoma, Neuroblastoma, Ewing/PNET and Rhabdomyosarcoma. Neuroblastoma, Retinoblastoma, Wilms Tumor, Hepatoblastoma show presentation in early childhood while Rhabdomyosarcoma is seen throughout childhood. The majority of round cells tumors have male predominance. This study emphasizes the role of immunohistochemistry (IHC) to arrive a definite diagnosis.


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A cross-sectional study on exclusive breastfeeding practice among lactating females attending medical college, district Jhansi (U.P)

2016-10-19T22-45-34Z
Source: International Journal of Medical Science and Public Health
Swati Singh, Nitin Tiwari, Anil Kumar Malhotra.
Background: Breast milk is an unequaled way of providing ideal food for the healthy growth and development of infants and has a unique biological and emotional influence on the health of both mother and child. Objectives: The present study was conducted to study the exclusive breastfeeding practice among females and its association with socio-demographic variables. Materials and Methods: The study was conducted on mothers attending the immunization clinic, for the period of four months between September 2015 to December 2015. The study was conducted on 400 nursing mothers, who were selected randomly using the simple random technique. Data was analyzed in SPSS 16 trial version. Chi-square test was used for comparison and statistical significance was taken at P value


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Predictors of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in patients with type-2 diabetes mellitus

2016-10-19T22-45-34Z
Source: International Journal of Medical Science and Public Health
R S Pushpa Kumari, V A Vipula, B Suresh Reddy, W Nagadeepa, B L N Reddy.
Background: Hepatic steatosis in Non-Alcoholics may range from a benign indolent deposition of fat [known as non-alcoholic fatty liver diseases (NAFLD)] to severe lipotoxicity-induced steatohepatitis with neuroinflammation [known as non-alcoholic steatohepatitis (NASH)]. NASH is an overlooked complication of Type-2 diabetes mellitus (T2DM) that if missed may carry serious long-term consequences. Objectives: To determine the Predictors of Non-alcoholic fatty liver disease and Non-alcoholic steatohepatitis in patients with Type-2 Diabetes Mellitus. Materials and Methods: Fatty liver Disease by Ultrasonography & various other relevant factors (clinical and biochemical) were measured in all study subjects. These parameters were compared among two study groups i.e. (NAFLD and normal Liver). The statistical analyses were done using Statistical Analytic system (SAS), Chi-square test & Fisher Exact test were applied. Results: Incidence of Non-alcoholic fatty liver disease in our study is around 62 (59.7%) of which 37 (55%) are males and 25 (45%) are females. The incidence of Non-alcoholic steatohepatitis in this study is around 22 (25.5%) of which 15 are males and 7 are females. BMI and WC values are significantly higher in the fatty liver group than normal group. (p


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A study of morbidity profile amongst construction workers at selected construction sites in Surendranagar city

2016-10-19T22-45-34Z
Source: International Journal of Medical Science and Public Health
Pratik K. Jasani, Jay H. Nimavat, Jwalant B Joshi, Girija P. Kartha.
Background: Work plays a central role in peoples lives whether it is on a construction site, in an office or in a factory. Workers constitute a large & important sector of the worlds population. The two broad categories of construction works are building & civil engineering. Construction workers in both categories are at greater risk of developing certain health disorders & sickness than workers in many other industries. They are exposed to multiple physical, chemical & biological agents, which make them vulnerable to various health problems that include injuries, respiratory problems, dermatitis, and musculoskeletal disorders (MSDs). Apart from this, in most of the construction projects, the workers employed are unorganized in nature & often not guided by the legislations made for the health & welfare of the workers & hence are not eligible for free or subsidized care. In this context, this study was conducted to understand the health problems of construction workers & to advocate public health measures for the promotion of health & prevention of diseases among construction workers. Objectives: To assess the morbidity profile amongst the construction workers & correlate the findings with the occupational profile of the workers. Materials and Methods: It was a Cross-sectional study carried out among 312 construction workers from 10 different construction sites selected by simple random sampling. Data was collected and analyzed by the Statistical package for Social Sciences. Microsoft Word & Excel have been used to generate graphs, tables etc. Results: The study revealed that most common morbidity among construction workers was one or other types of minor injuries (34%) followed by skin problems (25.64%) & MSDs (19.55%). Conclusion: Illiteracy, poor working conditions, lack of infrastructure & security, inadequate health service utilization make these workers a vulnerable population & it shows the imperative need for an overall socioeconomic development as a key for achieving the desired status.


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Treatment-seeking behaviour and community perceptions regarding malaria in Surat city

2016-10-19T22-45-34Z
Source: International Journal of Medical Science and Public Health
Anjali Modi, Sukesha Gamit, Sankalp Raj Choudhary, Rohit Parmar, Prakash Goghara, Abhay Kavishvar.
Background: Mosquito-borne diseases (MBDs) are a public health challenge in India. Rapid industrialisation and urbanisation leading to rural-urban migration have led to a surge in cases of malaria. Intense surveillance and vector control strategies are also essential for its control. Surat city being inhabited by migrants is endemic for malaria. Objectives: This study was conducted to find out knowledge about mosquito-borne diseases, treatment seeking behaviour and community perceptions about malaria in Surat city. Materials and Methods: A cross-sectional survey was conducted in all the seven zones of Surat city namely Central, West, North, West, South East, South West and East zones in the last quarter of the year 2010 with data collection in the month of October 2010. Data was collected in a pre-tested semi-structured open-ended questionnaire, containing questions on socio-demographic profile, knowledge about MBDs, protection from MBDs, public surveillance activities carried out by Government for MBDs and treatment seeking behaviour. Results: About 38.4 % people utilised public sector services for peripheral blood smear examination. The majority (95.4%) of the fever cases took treatment for malaria. Only 59 cases received radical treatment out of 78 Plasmodium vivax cases. About 70% and 55 % of the respondents had correct knowledge about diseases transmitted by mosquitoes and mosquito breeding habits respectively. Around 81% fever cases reported that health workers come to their area for taking peripheral blood smears. Conclusions: The MBD control efforts need to be directed more to health education regarding complete treatment of malaria including the radical treatment. More endeavours for information about mosquitoes and their breeding habits are required.


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Antimicrobial Susceptibility Monitoring of Bacterial Pathogens Isolated from Urinary Tract Infections in Dogs and Cats Across Europe: ComPath Results

Microbial Drug Resistance , Vol. 0, No. 0.


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Suppression of HBXIP Reduces Cell Proliferation, Migration and Invasion In Vitro, and Tumorigenesis In Vivo in Human Urothelial Carcinoma of the Bladder

Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0.


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