ROLE OF MIRNA-122 AND MIRNA-200B IN INTRATUMOR HETEROGENEITY FORMATION AND HUMAN BREAST CANCER PROGNOSIS

2016-09-12T01-16-32Z
Source: International Journal of Current Research and Review
Lukianova N., Borikun T., Yalovenko T., Chekhun V..
Aim: To determine the features of miR-122 and -200b expression signature in BC patients due to major clinical-pathological characteristics of the disease. Methodology: The expression levels of miR-122 and -200b and ER, PR, Her2/neu, Ki-67, E-cadh, N-cadh, FTH1, Hepc were analyzed in cancer tissue and sera of BC patients. Relative expression levels of the miR-122 and -200b were examined using qRT-PCR (Quantitative Reverse Transcription PCR), protein expression was measured by immunohistochemical analysis. Results: Correlation between miR-122 and -200b expression clinical-pathological characteristics of BC was established. Prognostic value of miR-122 and -200b was estimated. Discussion and Conclusion: Changes of miR-122 and -200b expression in tumor tissue and sera of BC patients provide information about major clinical-pathological characteristics of BC.


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STUDY OF LABORATORY PARAMETERS IN HEMOPHILIA PATIENTS

2016-09-12T01-16-32Z
Source: International Journal of Current Research and Review
T. B. Sadaria, H. M. Goswami, Safal Patel.
Introduction: Haemophilia is X- linked congenital bleeding disorder with a frequency of about one in 10,000 births. Haemophilia is caused by deficiency of coagulation factor VIII (haemophilia A) or factor IX (haemophilia B) related to mutations of clotting factor gene. Objectives: To check effectiveness of various screening and confirmatory tests for diagnosis of haemophilia. Methods: Retrospective study of laboratory diagnosis of haemophilia was conducted in our haematology section of pathology department of Tertiary Care Teaching Centre from 1 August 2014 to 30 July 2016. Patients in the age group of 0 year to 55 years with factor VIII and factor IX level below 50% of normal were included in the study. Routine haematological tests like haemoglobin and platelet count and coagulation profile of patient for prothrombin time, activated partial prothrombin time, factor VIII and factor IX level were analysed. Results: Out of 122 cases, 97 cases were of haemophilia A while 25 cases were of haemophilia B. Haemoglobin count of patients ranged from6gm% to 14.2 gm%. Platelet count and PT (prothrombin time)of patients were within normal limits. APTT (Activated Partial Thromboplastin Time) was prolonged (41.6 sec. to 124 sec) in all patients. Factor VIII level was reduced (


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AN ANTHROPOMETRIC STUDY OF STATURE ESTIMATION AMONG MALES FROM THE MEASUREMENTS OF FEET IN UDAIPUR DISTRICT OF RAJASTHAN

2016-09-12T01-16-32Z
Source: International Journal of Current Research and Review
Charu Taneja, Hitesh Babel, L.K. Jain.
Background: Estimation of stature has a very significant role to play in forensic anthropometry for personal identification. Objective: To discover out the correlation among proportions of feet with stature in tribals of Udaipur district in Rajasthan (India). Material and Methods: The present study was conducted on a total number of 481 male tribals of Udaipur district by using standard anthropometric techniques. Results: There was a high correlation between height and right (0.184) foot length & left (0.186) Foot Length in males. Conclusion: Linear regression equations were deduced in males out of which lowest standard error of estimate was experienced in combined foot length of males.


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ISOLATION AND PHARMACOLOGICAL STUDIES OF KARANJACHROMENE FROM THE SEEDS OF PONGAMIA PINNATA (L. PIERRE)

2016-09-11T23-14-43Z
Source: International Journal of Current Research and Review
Devendra N. Kage, Nuzhahat Tabassum, Vijaykumar B. Malashetty, Raghunandan Deshpande, Y. N. Seetharam.
Context: Isolation of chemical compound karanjachromene from the Seeds of Pongamia Pinnata and evaluation of its anti-inflammatory and analgesic activities. Materials and methods: Karanjachromene has been successfully extracted from the seeds of Pongamia Pinnata using n-hexane, petroleum ether and alcohol with Soxhlet extraction. Anti-inflammatory and analgesic activities of the some were assessed administering in Swiss albino mice. The anti-inflammatory activity of the test compound was determined by mice paw edema inhibition method. The analgesic activity was determined by both acetic acid induced writhing and tail immersion methods. Results: Karanjachromene at doses 25 mg/kg and 50 mg/kg shown 40.48% and 59.6% inhibition of paw edema respectively, at the end of 3 h standard drug diclofenac sodium produced 63.01% inhibition in paw volume at 10 mg/kg. The oral administration of test compound karanjachromene significantly inhibited writhing response induced by acetic acid in a dose dependent manner. Karanjachromene produced 29.64% and 42.14% inhibition of writhing at doses 25 mg/kg and 50 mg/kg respectively. Standard drug diclofenac sodium produced 56.47 % inhibition of writhing at 10 mg/kg. Discussion and Conclusion: The administration of karanjachrome is potent to inhibit the paw edema starting from the 1st hour and during all phases of inflammation, which may be due to inhibition of different inflammatory mediators. The acetic acid induced writhing response could be mediated by peritoneal mast cells, acid sensing ion channels and the prostaglandin pathways. The test compound inhibited both mechanisms of pain and inflammation and are more found active peripherally than centrally. Karanjachromene exhibited significant anti-inflammatory and analgesic agents


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A REVIEW OF MONOPOLISITC COMPETITION AMONG INTERNET SERVICE PROVIDERS

2016-09-11T23-14-43Z
Source: International Journal of Current Research and Review
Jehangir Bharucha.
The purpose of this research paper is to explore and analyse the monopolistically competitive Internet Service Providers (ISPs) market structure in Mumbai and their operative strategies. Assessing the various factors at play, the project focuses on the relative effect of the corresponding marketing strategies on subscribers and attempts to identify how inconsistencies between the assured services and its subsequent delivery, results in failing to capture the competitive advantage that is observed in other marketplaces. Factoring in the opinions and feedback of the survey respondents, as well as the conceptual tactics of non-price competition and product or service differentiation in a monopolistic market, the study proposes an informed framework to tackle the existing issues therein.


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LEPTOSPIROSIS – AN ENIGMATIC ZOONOSIS

2016-09-11T23-14-43Z
Source: International Journal of Current Research and Review
Mythri B.A..
Leptospirosis is a zoonosis which has a global distribution. The disease is still an enigma 130 years post discovery. Leptospirosis is mainly a disease of the animals like the rodents and various other animals, wherein man is an accidental host. Leptospira is a spirochete, which to be visualised in a dark field microscope or in a light microscope after special staining techniques. It is a slow growing organism and requires special media like the Fletcher`s medium. Leptospirosis results when the person comes in contact with the organism either as an occupational hazard or during avocational exposure or during floods. The pathogenesis of leptospirosis is incompletely understood. Despite years of speculation, the route and mode of entry of leptospires in natural infections is not clear. The site of entry into host is through mucosal surfaces. Important portals of entry are fresh or partially healed abrasions of the skin and intact mucosa of the buccal cavity, nasal passages or conjunctiva. The disease can be seen in two forms, the mild anicteric form and the severe icteric form also known as Weil`s disease. The diagnosed leptospirosis cases are just the tip of the iceberg; many go undiagnosed due to the protean manifestations of the disease. The drug of choice for treatment is Penicillin. Vaccines are available for animals. An approved vaccine for humans is still awaited.


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ISOLATION AND CHARACTERISATION OF DIATOMS FROM WATERBODIES OF MUMBAI

2016-09-11T23-14-43Z
Source: International Journal of Current Research and Review
Disha Rana, Deepika Bhandari.
Diatom plays an important role in Forensic Science and in the studies of water quality. Diatom acts as a supportive evidence for ascertaining the cause of death as well as the place of drowning. Presence of diatoms in the distant vital organs is an important method to distinguish between ante-mortem and post-mortem drowning. It is possible to pinpoint the site of drowning, if diatom species recovered from the tissues of the corpse are compared to that found in the water body from where the corpse is recovered. In the present study, 10 water bodies located in various parts of Mumbai were sampled for the study. Isolation of diatoms was carried out using acid digestion method. Total 35 species of diatoms were isolated and characterised. The diatom species identified belong to the following genera: Gyrosigma, Navicula, Melosira, Pinnularia, Surirella, Hantzschia, Eunotia, Fragilaria, Nitzschia, Gomphonema, Cymbella, Cyclotella, Neidim, Caloneis, Synedra, Epithemia, Frustulia. The information obtained helped to create a reference database on diatoms which can be utilized in future for ecological assessment and ready reference in drowning cases


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