Σάββατο 14 Μαΐου 2016

5th-graders, school nurse save teacher who suffered stroke

By Jamie Forsythe
The Belleville News-Democrat

BELLEVILLE, Ill. — Fifth-grader Rebecca Bagby says she "sprinted down the hall like a cheetah" to the school nurse's office when her teacher was in distress.

The students at Whiteside Middle School knew something was wrong. Russell was mumbling, his face was drooping on one side and he couldn't stay seated in his chair.

School nurse Amanda Eversgerd identified the signs of a stroke right away, and a staff member called 911.

Eversgerd is familiar with emergency situations from her previous job as a trauma nurse at St. Louis University Hospital.

"I've dealt with life-threatening situations before. It definitely is scary," Eversgerd said. "We moved very, very quickly."

When she got to Russell's classroom, he was on the floor behind his desk.

"I immediately knew something was terribly wrong," Eversgerd said. "I knew when I first spoke to him that it was a stroke. One side of his body was paralyzed. He was unable to move it."

Another teacher came in to help evacuate the students as they waited for paramedics to arrive.

"They were obviously very shaken up," Eversgerd said.

I immediately knew something was terribly wrong. I knew when I first spoke to him that it was a stroke. One side of his body was paralyzed. He was unable to move it.

One year later, the scary incident is still fresh in the minds of Russell, his former students and colleagues.

Most of the students in class were crying. "We thought he was going to die," Rebecca said. "We didn't know what was happening."

Student Dasia Napper said she was scared. "It was just crazy," she said. "I've never seen somebody have a stroke before."

Student Anaia Crow-Vindiola was "very, very scared. I was starting to cry, because I didn't know if he was going to die or if he was going to live."

Eversgerd was impressed with the maturity of the students.

"I was very, very taken back by the maturity students showed in the emergency situation and afterward," Eversgerd said. "Everyone was extremely mature about it."

She was especially impressed that the students were able to identify that Russell needed help even if he didn't say he did.

"It was beyond Mr. Russell to be able to help himself," Eversgerd said. "That fills me with a lot of pride — the caliber of the character of the students that were in the classroom."

At first, Rebecca, said she and other students thought their teacher was "being funny because he likes to joke with us." Then, "We saw him starting to drool. One side of his lip was drooping down."

Dasia said she got another teacher while Rebecca went to the school nurse's office.

Now in sixth grade, Whiteside Middle School students remember what happened and what they did to help their teacher Blair Russell who suffered a stroke while teaching math last May.

Russell's perspective
Russell, 38, vividly remembers suffering a stroke at 1:30 p.m. May 4, 2015. The day before, Russell said he and his wife, Macy, were coming back from Wisconsin where they were visiting family. It was a 9-hour drive.

"I felt fine. I just felt very tired all day," he said. "I just thought it was the trip that we did."

Around 1:20 p.m. Russell recalled getting numbness in his left hand. "My last three fingers, they just started feeling numb. I started pinching them. I bit them. I couldn't feel anything.

"My kids started saying 'Mr. Russell, you sound funny.' I was teaching math at the time."

Russell got a glass of water from behind his desk. "Water started coming out of the side of my mouth whenever I started talking," he said.

He went back to his desk to sit down, because he said he "wasn't feeling right."

That's when the tingling started coming up his arm and his leg started becoming numb. "I sat down or I attempted to sit down," Russell said. "I fell out of my chair. The kids thought I was joking because I mess around with my kids a lot and joke around with them."

Three boys in his class tried to pick him up, he said. "I was deadweight. I couldn't move," Russell said. "They couldn't move me, and at that point I started getting scarred."

I was just scared out of my mind that I was going to die right there on the floor.

Russell has a had a heart condition since birth — hypertrophic cardiomyopathy. "At first since it was my left arm, I thought I was having a heart attack," he said.

Then after thinking about the slurred speech, Russell said he thought he may be having a stroke. "I didn't think I was old enough to have one of those," said Russell, whose grandfather had a stroke when he was in his late 70s.

The school nurse, Eversgerd, came in and told Russell he was having a stroke. "That's when it hit me very hard," he said. "I tried to remember everything. Anything I ever heard about a stroke is you forget things and lose your money."

Russell said he was "scared to death" that his kids were in the room. He remembers wondering what they must be thinking and feeling.

"I was just scared out of my mind that I was going to die right there on the floor," he said.

The EMTs took him to St. Elizabeth's Hospital in Belleville. "I had no idea what's going on. I was going in and out," Russell said.

Blood clot removal
Russell suffered an ischemic stroke, which means a clot was blocking blood supply to the brain, said Dr .Jin-Moo Lee, a neurologist who specializes in strokes. Lee treated Russell at Barnes-Jewish Hospital in St. Louis.

"He had a blockage of a major artery — one of the largest arteries in the brain," Lee said. "This was on the right side of the brain, which is why he had the weakness on the left side."

In Russell's case, blood was not flowing through the part of the brain where the clot was. It was critical to get the blockage removed and blood flowing as quickly as possible.

At St. Elizabeth's, Russell remembers seeing a doctor on a computer screen. "They wanted to see my face to see how serious it was," he said. "I remember them saying, 'You have to get him to Barnes as soon as possible. He's going to lose more if we don't take care of this right now.'"

According to Lee, there's a shortage of stroke specialists in the country, which is where telemedicine comes in. It's hard for a doctor not familiar with strokes to determine the right course of action.

As a result of the specialist seeing Russell's face, he received a tissue plasminogen activator. "It's an intravenous medicine that is used to dissolve blood clots that cause blockages in the arteries," Lee said. "Then he was immediately transferred to us at Barnes-Jewish Hospital."

Russell said he doesn't remember anything about the helicopter ride except the noise.

Upon arrival, he was taken into surgery where an interventional neuroradiologist used a small catheter, threaded it up through his leg to his brain, grabbed the clot and removed it.

"You can actually snare that clot and pull it out mechanically," Lee said. "It took three passes (with Russell). They had to go in and out three times. They finally got it. They pulled the clot out and then shortly thereafter his symptoms began to resolve. ... He was able to regain a lot of the function that was initially lost."

The procedure was done less than six months after several studies were published in January 2015, Lee said, that found this new therapy called thrombectomy was "proven to be effective for exactly this type of stroke."

At Barnes, Lee explained thrombectomy wasn't adopted as the standard of care until those studies came out. "Before that, we did it on a case-by-case basis," he said.

Eight days later, Russell returned to his classroom to finish out the school year and, most importantly, let his kids know he was OK.

"I wanted to prove to my kids that I was strong enough to come back, and I wanted them to see me, because they saved my life too by going to get the nurse," he said. "I was stubborn, telling them no, no, I'm fine, I'm fine. They went out of their way and got the nurse and made sure I was OK."

His students were thankful to have him back.

"I was really, really relieved," Anaia said. "I was glad, because he was one of my favorite teachers. It made me feel a lot better, and I didn't have to worry anymore."

Rebecca said Russell is her "favorite teacher of all time."

Now a year later, Russell said he has only minimal lasting effects from the stroke. Three of his fingers on his left hand are still weak, and he has some memory issues.

"To have those two be my only side effects after a stroke, I consider myself very lucky," he said.

Russell admits he still doesn't sleep "great" as he's worried it's going to happen again. He's taking blood thinners, which doctors say reduce the risk.

I wanted to prove to my kids that I was strong enough to come back, and I wanted them to see me, because they saved my life too by going to get the nurse.

The stroke wasn't Russell's only major medical emergency last year. Right before Thanksgiving, Russell's defibrillator shocked his heart while he was dancing as part of a skit. He was transported by ambulance to the hospital from the school.

"It felt like somebody punched me in the chest as hard as they could," he said. "It was a crazy, crazy year."

Stroke symptoms, awareness
Lee said it can be difficult to identify a stroke since the signs are different depending on what area of the brain it's in.

The most common symptoms, he said, are the sudden onset of weakness on one side of the body; numbness on one side of the body; inability to communicate, either understand or create speech; and inability to see out of one eye or one visual field.

"The hallmark of a stroke is it happens suddenly," Lee said. "One moment you're OK and within moments, you have these deficits."

When a stroke happens, time is of the essence. "When a stroke occurs, the brain tissue doesn't all die at once. ...The death occurs over a period of minutes to hours," he said. "As the stroke is evolving, the earlier you intervene with the therapy, the more effective that therapy is."

For the procedure Russell had, Lee said, that therapy window is six hours. "Time is really critical," he said.

May is National Stroke Awareness month.

"It's important for everyone to recognize a stroke," said Eversgerd, the school nurse at Whiteside.

Whiteside Middle School has cardiopulmonary resuscitation training with staff members, which includes stroke symptom awareness.

The school has a first aid and CPR unit for sixth-grade classes.

Training children and young people is important, Eversgerd said. "Who is going to be with those people who are most likely to suffer from a stroke? Their kids,"

Russell appreciates all the support he received from students and staff members at Whiteside.

"The students and teachers all helped me get my strength back," he said, "and I owe them a lot."

Since his life scares last year, Russell said he appreciates life even more now.

"Live everyday like its your last, hug everybody; and that's what I've done," he said. "I don't let things get to me as much as they did back then. I would get mad and frustrated a lot, but now I have even more patience than I did when I first started teaching. It could be my last day. I almost died twice."

Copyright 2016 the Belleville News-Democrat



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Correlation of probability scores of placenta accreta on magnetic resonance imaging with hemorrhagic morbidity

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To evaluate the hypothesis that assigning grades to magnetic resonance imaging (MRI) findings of suspected placenta accreta will correlate with hemorrhagic outcomes. We chose a single-center, retrospective, observational design.

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Impact of aortic root size on left ventricular afterload and stroke volume

Abstract

Purpose

The left ventricle (LV) ejects blood into the proximal aorta. Age and hypertension are associated with stiffening and dilation of the aortic root, typically viewed as indicative of adverse remodeling. Based on analytical considerations, we hypothesized that a larger aortic root should be associated with lower global afterload (effective arterial elastance, EA) and larger stroke volume (SV). Moreover, as antihypertensive drugs differ in their effect on central blood pressure, we examined the role of antihypertensive drugs for the relation between aortic root size and afterload.

Methods

We studied a large group of patients (n = 1250; 61 ± 12 years; 78 % males; 64 % hypertensives) from a single-center registry with known or suspected coronary artery disease. Aortic root size was measured by echocardiography as the diameter of the tubular portion of the ascending aorta. LV outflow tract Doppler was used to record SV.

Results

In the population as a whole, after adjusting for key covariates in separate regression models, aortic root size was an independent determinant of both SV and EA. This association was found to be heterogeneous and stronger in patients taking a calcium channel blocker (CCB; 10.6 % of entire population; aortic root size accounted for 8 % of the explained variance of EA).

Conclusion

Larger aortic root size is an independent determinant of EA and SV. This association was heterogeneous and stronger in patients on CCB therapy.



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Analysis of cardio-pulmonary and respiratory kinetics in different body positions: impact of venous return on pulmonary measurements

Abstract

Purpose

The aim of the study was to compare the kinetics responses of heart rate (HR), pulmonary ( \(\dot{V}\) O2pulm), and muscular ( \(\dot{V}\) O2musc) oxygen uptake during dynamic leg exercise across different body positions (−6°, 45°, and 75°).

Methods

Ten healthy individuals [six men, four women; age 23.4 ± 2.8 years; height 179.7 ± 8.3 cm; body mass 73 ± 12 kg (mean ± SD)] completed pseudo-random binary sequence (PRBS) work rate (WR) changes between 30 and 80 W in each posture. HR was measured beat-to-beat by echocardiogram and \(\dot{V}\) O2pulm by breath-by-breath gas exchange. \(\dot{V}\) O2musc kinetics were assessed by the procedure of Hoffmann et al. (Eur J Appl Physiol 113:1745–1754, 2013) applying a circulatory model and cross-correlation functions (CCF).

Results

For \(\dot{V}\) O2pulm kinetics significant differences between −6° (CCF-values: 0.292 ± 0.040) and 45° (0.256 ± 0.034; p < 0.01; n = 10) as well as between −6° and 75° (0.214 ± 0.057; p < 0.05; n = 10) were detected at lag '40 s' of the CCF course as interaction effects (factors: Lag × Posture). HR and \(\dot{V}\) O2musc kinetics yield no significant differences across the postures.

Conclusions

The analysis of cardio-dynamic and respiratory kinetics, especially with an emphasis on muscular and cellular level, has to consider venous return and cardiac output distortions. Simplified observations of kinetics responses resulting in time constants and time delays only should be replaced by the time-series analysis for a more sophisticated evaluation. The results illustrate that isolated \(\dot{V}\) O2pulm measurements without cardio-dynamic influences may not represent the kinetics responses originally revealed at muscular level.



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Increased IL-17A/IL-17F expression ratio represents the key mucosal T helper/regulatory cell-related gene signature paralleling disease activity in ulcerative colitis

Abstract

Background

T helper (Th) and regulatory T (Treg) cell-related cytokines are implicated in inflammatory bowel diseases, including ulcerative colitis (UC). While these cytokines are generally upregulated in inflamed mucosae, the key cytokine profile explaining disease severity has not been determined.

Methods

The Rachmilewitz endoscopic index (REI) was assessed in 61 UC patients undergoing colonoscopy. Biopsies obtained from inflamed (REI 3–12) and noninflamed (REI 0–2) areas were analyzed by quantitative PCR for expression of mRNAs encoding cytokines and transcription factors related to Th1 (TNF-α, IFN-γ, IL-12p35, IL-12p40, and T-bet), Th2 (IL-4, IL-13, IL-33, and GATA3), Th17 (IL-17A, IL-17F, IL-21, IL-22, IL-23p19, IL-6, and RORC), Th9 (IL-9, IRF4, and PU.1), and Treg (TGF-β and Foxp3). Expression patterns associated with higher REI were determined by univariate and multivariate analyses.

Results

Despite general upregulation, none of these mRNAs showed univariate correlation with REI in inflamed samples. Multiple regression analysis, however, found that joint expression of IL-17A, IL-17F, IL-21, RORC, and TGF-β was significantly predictive of REI (P < 0.0002, R2 = 0.380), with major individual contributions by IL-17A (P < 0.0001) and IL-17F (P < 0.0001), which were associated with increased and decreased REI, respectively. Partial correlation analysis, validating this model, indicated differences between IL-17A and IL-17F in correlating with other targets. The IL-17A/IL-17F ratio showed a significant correlation with REI (r = 0.5124, P < 0.0001), whereas no other mRNAs were essentially predictive of REI.

Conclusions

Mucosal IL-17A/IL-17F ratio significantly correlates with endoscopic score in UC patients, accompanied by their disparate interactions with other Th/Treg-related genes.



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Burst-suppression is reactive to photic stimulation in comatose children with acquired brain injury

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Publication date: Available online 14 May 2016
Source:Clinical Neurophysiology
Author(s): Dragos A. Nita, Mihai Moldovan, Roy Sharma, Sinziana Avramescu, Hiroshi Otsubo, Cecil D. Hahn
ObjectiveBurst-suppression is an electroencephalographic pattern observed during coma. In individuals without known brain pathologies undergoing deep general anesthesia, somatosensory stimulation transiently increases the occurrence of bursts. We investigated the reactivity of burst-suppression in children with acquired brain injury.MethodsIntensive care unit electroencephalographic monitoring recordings containing burst-suppression were obtained from 5 comatose children with acquired brain injury of various etiologies. Intermittent photic stimulation was performed at 1 Hz for 1 minute to assess reactivity. We quantified reactivity by measuring the change in the burst ratio (fraction of time in burst) following photic stimulation.ResultsPhotic stimulation evoked bursts in all patients, resulting in a transient increase in the burst ratio, while the mean heart rate remained unchanged. The regression slope of the change in burst ratio, referred to as the standardized burst ratio reactivity, correlated with subjects' Glasgow Coma Scale scores.ConclusionsReactivity of the burst-suppression pattern to photic stimulation occurs across diverse coma etiologies. Standardized burst ratio reactivity appears to reflect coma severity.SignificanceMeasurement of burst ratio reactivity could represent a simple method to monitor coma severity in critically ill children.



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Median arcuate ligament syndrome in athletes

Abstract

Background

Exercise-related transient abdominal pain (ETAP) is a common entity in young athletes. Most occurrences are due to a "cramp" or "stitch," but an uncommon, and often overlooked, etiology of ETAP is median arcuate ligament syndrome (MALS). The initial presentation of MALS typically includes postprandial nausea, bloating, abdominal pain, and diarrhea, but in athletes, the initial presentation may be ETAP.

Methods

We present a case series of three athletes who presented with exercise-related transient abdominal pain and were ultimately diagnosed and treated for MALS. Unlike other patients with median arcuate ligament syndrome, these athletes presented with exercise-induced pain, rather than the common postprandial symptoms. These symptoms persisted despite conservative measures. Work-up of patients with suspected MALS include a computed tomography or magnetic resonance angiography showing compression of the celiac artery with post-stenotic dilation, or a celiac artery ultrasound demonstrating increased velocities (>200 cm/s2) with deep exhalation.

Results

All patients underwent a laparoscopic median arcuate ligament release. Postoperatively, there were no complications, and all were discharged home on postoperative day #2. All patients have subsequently returned to athletics with resolution of their symptoms.

Conclusion

ETAP is common in athletes and often resolves with preventative or conservative strategies. When ETAP persists despite these methods, alternative causes, including MALS, should be considered. A combination of a thorough history and physical exam, as well as radiographic data, is essential to make the appropriate diagnosis and treatment strategy.



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