RANDOMIZED CONTROLLED TRIAL OF TRANEXAMIC ACID AMONG PARTURIENTS AT INCREASED RISK FOR POSTPARTUM HEMORRHAGE UNDERGOING CESAREAN DELIVERY IN A TERTIARY CARE TEACHING HOSPITAL AT RIMS KADAPA

2016-08-09T05-51-53Z
Source: Indo American Journal of Pharmaceutical Research
Dr. T. Lakshmi Suseela*, Dr. S. Jaya Jyothi, Dr. P. Rabbani, Dr. Chb. Jhonsi.
Objective: To assess the effects of tranexamic acid among patients undergoing cesarean delivery who were at high risk of postpartum hemorrhage for Obstetrics and Gynaecology department in RIMS Kadapa. Methods: Between August 1, 2014, and April 30, 2015, a randomized controlled trial was performed at a tertiary care teaching hospital at kadapa. Women undergoing an elective or emergency cesarean delivery who were at high risk for postpartum hemorrhage were enrolled. They were randomly assigned using sealed, opaque envelopes to receive 10 mg/kg tranexamic acid or normal saline 10 min before skin incision. Anesthesiologists were not masked to group assignment, but patients and obstetricians were. The primary outcome was need for additional uterotonic drugs within 24 h after delivery. Analyses were by intention to treat. Results: Thirty patients were assigned to each group. Additional uterotonic drugs were required in 7 (23%) patients assigned to tranexamic acid and 25 (83%) patients in the control group (P

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