Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0.
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Σάββατο 27 Αυγούστου 2016
99mTc-3PRGD2 SPECT/CT Imaging for Monitoring Early Response of EGFR-TKIs Therapy in Patients with Advanced-Stage Lung Adenocarcinoma
The Heart of the Pressor Effect: Acute Caffeine Ingestion and Resting Heart Rate Variability
Journal of Caffeine Research , Vol. 0, No. 0.
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Armed Security Officer - Paramedic - Allied Universal Security Services
Are you looking for a growing company with great benefits and future opportunities" Allied Universal, North America's leading security services provider, is experiencing tremendous growth. For all full-time positions, we offer medical, dental, vision, flex spending, 401K, an anniversary bonus, and an on-the-spot recognition program. We promote from within our company! You can start with little, to no ...
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Paramedic - MedStar Mobile Healthcare
MedStar Mobile Healthcare, or MedStar, is the trade name of the Area Metropolitan Ambulance Authority. We are the exclusive 911 provider for the City of Fort Worth and the Client Cities of Blue Mound, Burleson, Edgecliff, Forest Hill, Haltom City, Haslet, Lakeside, Lake Worth, River Oaks, Sansom Park, Saginaw, Westover Hills, Westworth Village, and White Settlement. Our system is the 17th largest in ...
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Vice President of Billing - Allegiance Mobile Health
POSITION TITLE: Vice President of Billing SUMMARY: The Vice President of Billing and Collections is responsible for the successful operation of patient and facility billing, collections, and service through leadership and oversight of all operational elements of billing to support EMS services for Allegiance Mobile Health. Responsible for operational compliance with company policies and procedures in ...
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Applications Data Coordinator - Kentucky Board of Emergency Medical Services
Position Description This position is a critical role in the agency's management of certification and licensure documentation, electronic prehospital care report data, and dissemination of information through various Internet channels. The position makes use of reporting tools from multiple data sources to fulfil requests for information and provides both agency internal and public facing support ...
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EMT - Paramedic in West Point, NY - Spectrum Healthcare Resources
Spectrum Healthcare Resources has an opportunity for a civilian Emergency department Paramedics (EMT-P) at Keller Army Hospital in West Point, NY. The EMT-P position offers: Part time and PRN positions available 12 hour shifts Competitive salary The Emergency Department Paramedics (EMT-P) will have the following requirements: Graduation from an accredited EMT-paramedic (EMT-P) certification program ...
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EMT - Paramedic - Spectrum Healthcare Resources
Spectrum Healthcare Resources has an opportunity for a civilian EMT-Paramedic at Whiteman Air Force Base in Knob Knoster, MO. The EMT - Paramedic position offers: Opportunity to care for Military Families Paid Time Off Medical, Dental, Vision & 401K The EMT - Paramedic will have the following requirements: Knowledge of human anatomy and physiology; emergency medical treatment to include CPR; aseptic ...
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Firefighter/EMT - Citrus Sheriff Fire Rescue
CITRUS SHERIFF FIRE RESCUE 1 DR. MARTIN LUTHER KING JR. AVENUE INVERNESS, FLORIDA 34450 http://ift.tt/2bQ9a08 Updated: August 09, 2016 Job Classification: Firefighter/EMT The Citrus Sheriff Fire Rescue is currently building an ongoing eligibility list for Firefighter/EMT. Citrus County requires both FireTEAM and a valid NTN CPAT through National Testing Network (NTN) ...
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Firefighter Paramedic - City of South Pasadena
SOUTH PASADENA, CITY OF 911 OLEANDER WAY S. SOUTH PASADENA, FLORIDA 33707 Updated: August 19, 2016 Classification: Firefighter/Paramedic The City of South Pasadena is currently accepting applications for Firefighter/Paramedic. This position requires FireTEAM and a valid NTN CPAT through National Testing Network (NTN). All testing must be completed by August 29, 2016. Starting Salary: $47,549 base Benefit ...
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Firefighter/EMT - Ormond Beach Fire Department
ORMOND BEACH FIRE DEPARTMENT 22 SOUTH BEACH STREET ORMOND BEACH, FLORIDA 32174 http://ift.tt/2bXf8db Updated: August 23, 2016 Job Classification: Firefighter/EMT The Ormond Beach Fire Department is currently hiring for an immediate opening for Firefighter/EMT. This position requires FireTEAM through National Testing Network (NTN) and a valid NTN CPAT. All testing must be completed by September ...
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Northshore Fire Department - Northshore Fire Department
NORTHSHORE FIRE DEPARTMENT 7220 NE 181st Street KENMORE, WASHINGTON 98028 Updated: August 19, 2016 Classification: Firefighter/EMT The Northshore Fire Department is currently building a list of entry level applicant profiles from National Testing Network (NTN) for a January 2nd, 2017 hire date. All testing must be complete and posted by September 23rd, 2016. Salary Information: $5,058.15/month (2016 ...
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Corrigendum to “Expert consensus paper on the use of Vedolizumab for the management of patients with moderate-to-severe Inflammatory Bowel Disease” [Dig. Liver Dis. 48 (2016) 360–370]
In the last paragraph of Section 1, the sentence "VDZ is a monoclonal antibody blocking the α4β7 integrin which is selectively expressed by the vascular endothelium in the gastrointestinal tract [7]" should be replaced with: "VDZ is a monoclonal antibody blocking the α4β7 integrin which is selectively expressed by the activated GUT homing lymphocytes [7]".
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Endoscopic peroral jejunal fecal microbiota transplantation
Fecal microbiota transplantation (FMT) is a valuable treatment modality for recurrent Clostridium difficile (C. difficile) colitis. Multiple questions including the best delivery route and volume remain unanswered. Here, we report a case series of high-volume FMT using endoscopic jejunal application route.
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Serum hepatocyte apoptosis biomarker predicts the presence of significant histological lesion in chronic hepatitis B virus infection
Hepatocyte death, either apoptosis or necrosis, is closely associated with hepatic inflammation and fibrosis.
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An alternate red and white colour-changing rectal carcinoid tumour
A 56-year-old female presented with a 3-month history of diarrhoea and abdominal pain. Colonoscopy examination found a mass (approximately 0.5×0.6×0.3cm) in the rectum 5cm from the anus. The overlying mucosa regularly alternated colour from white (Fig. 1) to red (Fig. 2) approximately every 10s. Endoscopic ultrasonography revealed its origin in the submucosa, and rectal carcinoid tumour was suspected. However, an ulcerative lesion was found in the transverse colon, and was pathologically diagnosed as adenocarcinoma.
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Outcome of acute severe ulcerative colitis in patients previously exposed to immunosuppressive therapy
We aimed to evaluate the outcome of patients with acute severe ulcerative colitis previously exposed to immunosuppressive (IMS) therapy.
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Occupational risk for Crohn's disease: A two-center study
Occupational factors have been suggested as possible elements in the etiology of Crohn's disease, although evidences have not been fully obtained.
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The addition of a sagittal cervical posture corrective orthotic device to a multimodal rehabilitation program improves short and long term outcomes in patients with discogenic cervical radiculopathy
Publication date: Available online 27 August 2016
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Ibrahim M. Moustafa, Aliaa A. Diab, Shimaa Taha, Deed E. Harrison
ObjectiveTo investigate the immediate and 1-year effects of a multimodal program, with cervical lordosis and anterior head translation (AHT) rehabilitation, on the severity of pain, disability, peripheral and central nervous system function in patients with discogenic cervical radiculopathy (DCR).DesignA randomized controlled study with a 1-year and 10-week follow-up.SettingUniversity research laboratory.Participants40 (27 males) patients with chronic DCR, a defined hypolordotic cervical spine and AHT posture were randomly assigned to the control (43.9 ± 6.2 years of age) or an intervention group (41.5 ± 3.7 years of age).InterventionsBoth groups received the multimodal program; additionally, the intervention group received the denneroll cervical traction device.Main Outcome MeasuresAHT, cervical lordosis, arm pain, neck pain and disability (NDI), dermatomal somatosensory evoked potentials (DSSEP's) and central somatosensory conduction time (N13-N20). Measures were assessed at three time intervals: baseline, 10 weeks, and 1 year follow up.ResultsAfter 10 weeks of treatment, between group analysis, showed equal improvements for both the intervention and control groups in arm pain intensity (p=0.4), neck pain intensity (p=0.6), and latency of DSSEP's (p=0.6). However, also at 10 weeks, there were significant differences between groups favoring the intervention group for cervical lordosis (p˂0.0005), AHT (p˂0.0005), amplitude of DSSEP's (p˂0.0005), N13-N20 (p˂0.0005), and NDI (p˂0.0005). Whereas, at the 1 year follow-up, between group analysis identified a regression back to baseline values for the control group. Thus, all variables were significantly different favoring the intervention group at 1-year follow up period: cervical lordosis (P˂0.0005), AHT (P˂0.0005), latency and amplitude of DSSEP's (P˂0.0005), N13-N20 (P˂0.0005), severity of neck and arm pain, and NDI (P˂0.0005) in favor of the denneroll group.ConclusionThe addition of the denneroll cervical orthotic to a multimodal program positively affected DCR outcomes at long term follow up. We speculate the improved cervical lordosis and reduced AHT contributed to our findings.
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Psychometric properties of a core set of measures of balance for people with cerebellar ataxia secondary to multiple sclerosis
Publication date: Available online 27 August 2016
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Stanley Winser, Catherine M. Smith, Leigh A. Hale, Leica S. Claydon, Susan L. Whitney, Brooke Klatt, John Mottershead, Islam Zaydan, Rock Heyman
ObjectiveTo examine the reliability, validity and interpretability of four clinical measures in assessing the severity of balance dysfunction among people with cerebellar ataxia (CA) secondary to multiple sclerosis (MS).DesignCross sectional observation study.SettingData collected across four outpatient clinics in New Zealand and United States of America.ParticipantsSixty consecutive participants with CA secondary to MS.Main outcome measuresBalance was assessed and video-recorded using the Berg Balance Scale (BBS), Timed Up and Go (TUG) test, the posture and gait sub-component of the International Co-operative Ataxia Rating Scale (PG-ICARS) and gait, stance and sit sub-components of the Scale for the Assessment and Rating of Ataxia (SARABal). The videos were later used to estimate reliability. The Barthel Index, Expanded Disability Status Scale (EDSS), ICARS and SARA were assessed and disease duration recorded.ResultsReliability was good for all four measures (range between ICC 0.95 and 0.99). Internal consistency was moderate to good for all four measures (α range 0.72-0.94), moderate to good correlation between the measures of balance (ρS range 0.72-0.85) and poor to moderate correlation with disease severity (EDSS), functional independence (Barthel Index) and disease duration (ρS range -0.37 to 0.76). Minimal Detectable Change (MDC) was derived for BBS (3), PG-ICARS (2) and SARABal (2). Measures were able to discriminate between assistive walking device users and non-users.ConclusionsAll four measures showed good reliability and acceptable validity; however, owing to the item repetition in scoring of the PG-ICARS and moderate construct, criterion and convergent validity of the TUG, the BBS and SARABal are recommended for balance assessment in clinical practice for people with CA secondary to MS.
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Effects of a balance-based exergaming intervention using the Kinect sensor on posture stability in individuals with Parkinson’s disease: a single-blinded randomized controlled trial
The present study examined the effects of a balance-based exergaming intervention using the Kinect sensor on postural stability and balance in people with Parkinson's disease (PD).
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Heimlich Maneuver learned in school saves mom's life
By Kirk Barron
Appeal-Democrat, Marysville, Calif.
MARYSVILLE, Calif. — Irene Guzman was eating dinner on Aug. 15 when a piece of chicken lodged in her throat. Unable to breathe or communicate, the fast reactions of her children, Alfonso Fernandez, 16, and Araceli Fernandez, 12, likely saved her life.
Araceli called 911 and alerted Alfonso, who was in his bedroom. Alfonso rushed to his mother to perform the Heimlich maneuver, which he learned nearly three years ago as an eighth-grader in Karen Dahlen's First Aid and CPR class at Andros Karperos School.
"They were my superheroes," Guzman said. "It was really scary thinking that I was going to be gone and they were going to be left all alone."
Guzman credited Dahlen's class for giving Alfonso the training and confidence to perfectly perform the Heimlich maneuver that cleared her throat. Paramedics arrived a short time later and examined Guzman, who did not have any bruising or broken ribs.
"They asked him how he knew what to do, and he told them he learned it at AK School in the eighth-grade health class," Guzman said. "He remembered exactly how to do it."
Alfonso, now a junior at River Valley High School, said he did not have to think about what to do. He just reacted to the situation.
The steps were second nature after going through training in Dahlen's class. First they watched a video about the Heimlich, then Dahlen demonstrated it, and they practiced on life-sized CPR dolls.
"They train you pretty well. I just started doing it," Alfonso said. "I didn't realize how serious it was until I saw her panicking."
Araceli is in seventh grade at AK School and plans on taking the class next year when she is old enough. She, too, said she reacted on instinct to call 911 and grab her brother when she realized her mother was in danger.
Dahlen, who teaches science at AK School, started the class about five years ago as one of the school's elective courses. The course is a semester long, so two classes of eighth-graders take it each school year.
At the end of the semester, the students take a test to become CPR and First Aid certified through the American Red Cross, Dahlen said.
"I tell the kids the reason why we do it is not because I expect them to go out and save some stranger at the mall. It's important to be trained because something could happen at home," Dahlen said.
Even the students who do not receive their certification learn valuable skills that can help in emergency situations, which is why Dahlen went out and became a licensed CPR instructor through the Red Cross and put together the program using National Safety Council curriculum.
"It's not watered down. If anything, we spend more time on it because they are eighth-graders," Dahlen said.
The program is the only one of its kind in Yuba City Unified School District, and Dahlen said she cried when her principal, Lee McPeak, called her to tell her about her former student's actions.
"When you're a teacher, you sometimes don't know how far reaching the things you do in class are," Dahlen said. "This is definitely an amazing moment."
McPeak said the idea for the class came from Dahlen after the district created space in the class master schedule for electives. He asked his staff to dig deep and find a passion for something great for the kids.
"I'm proud of Karen, and I think her vision for the program is fantastic," McPeak said. "When Irene called me, I can tell you that I left that phone call incredibly moved. I couldn't be more proud of Alfonso and what he was able to do for his family.
Copyright 2016 the Appeal-Democrat
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Interpregnancy Interval and Childbirth Outcomes in California, 2007–2009
Abstract
Objectives The goals of interconception care are to optimize women's health and encourage adequate spacing between pregnancies. Our study calculated trends in interpregnancy interval (IPI) patterns and measured the association of differing intervals with birth outcomes in California. Methods Women with "non-first birth" deliveries in California hospitals from 2007 to 2009 were identified in a linked birth certificate and patient discharge dataset and divided into three IPI birth categories: <6, 6–17, and 18–50 months. Trends over the study period were tested using the Cochran-Armitage two-sided linear trend test. Chi square tests were used to test the association between IPI and patient characteristics and selected singleton adverse birth outcomes. Results Of 645,529 deliveries identified as non-first births, 5.6 % had an IPI <6 months, 33.1 % had an IPI of 6–17 months, and 61.3 % had an IPI of 18–50 months. The prevalence of IPI <6 months declined over the 3-year period (5.8 % in 2007 to 5.3 % in 2009, trend p value <0.0001).Women with an IPI <6 months had a significantly higher prevalence of early preterm birth (<34 weeks), low birthweight (<2500 g), neonatal complications, neonatal death and severe maternal complications than women with a 6–17 month or 18–50 month IPI (p < 0.005). Comparing those with a 6–17 month vs 18–50 month IPI, there were increased early preterm births and decreased maternal complications, complicated delivery, and stillbirth/intrauterine fetal deaths among those with a shorter IPI. Conclusions for Practice In California, women with an IPI <6 months were at increased risk for several birth outcomes, including composite morbidity measures.
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Infant Feeding Decision-Making and the Influences of Social Support Persons Among First-Time African American Mothers
Abstract
Background While breast milk is considered the gold standard of infant feeding, a majority of African American mothers are not exclusively breastfeeding their newborn infants. Objective The overall goal of this critical ethnographic research study was to describe infant feeding perceptions and experiences of African American mothers and their support persons. Methods Twenty-two participants (14 pregnant women and eight support persons) were recruited from public health programs and community based organizations in northern California. Data were collected through field observations, demographic questionnaires, and multiple in-person interviews. Thematic analysis was used to identify key themes. Results Half of the mothers noted an intention to exclusively breastfeed during the antepartum period. However, few mothers exclusively breastfed during the postpartum period. Many participants expressed guilt and shame for not being able to accomplish their antepartum goals. Life experiences and stressors, lack of breastfeeding role models, limited experiences with breastfeeding and lactation, and changes to the family dynamic played a major role in the infant feeding decision making process and breastfeeding duration. Conclusions for Practice Our observations suggest that while exclusivity goals were not being met, a considerable proportion of African American women were breastfeeding. Future interventions geared towards this population should include social media interventions, messaging around combination feeding, and increased education for identified social support persons. Public health measures aimed at reducing the current infant feeding inequities would benefit by also incorporating more culturally inclusive messaging around breastfeeding and lactation.
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Added diagnostic value of magnetoencephalography (MEG) in patients suspected for epilepsy, where previous, extensive EEG workup was unrevealing
Source:Clinical Neurophysiology, Volume 127, Issue 10
Author(s): Lene Duez, Sándor Beniczky, Hatice Tankisi, Peter Orm Hansen, Per Sidenius, Anne Sabers, Anders Fuglsang-Frederiksen
ObjectiveTo elucidate the possible additional diagnostic yield of MEG in the workup of patients with suspected epilepsy, where repeated EEGs, including sleep-recordings failed to identify abnormalities.MethodsFifty-two consecutive patients with clinical suspicion of epilepsy and at least three normal EEGs, including sleep-EEG, were prospectively analyzed. The reference standard was inferred from the diagnosis obtained from the medical charts, after at least one-year follow-up. MEG (306-channel, whole-head) and simultaneous EEG (MEG–EEG) was recorded for one hour. The added sensitivity of MEG was calculated from the cases where abnormalities were seen in MEG but not EEG.ResultsTwenty-two patients had the diagnosis epilepsy according to the reference standard. MEG–EEG detected abnormalities, and supported the diagnosis in nine of the 22 patients with the diagnosis epilepsy at one-year follow-up. Sensitivity of MEG–EEG was 41%. The added sensitivity of MEG was 18%. MEG–EEG was normal in 28 of the 30 patients categorized as 'not epilepsy' at one year follow-up, yielding a specificity of 93%.ConclusionsMEG provides additional diagnostic information in patients suspected for epilepsy, where repeated EEG recordings fail to demonstrate abnormality.SignificanceMEG should be included in the diagnostic workup of patients where the conventional, widely available methods are unrevealing.
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Repetitive facial nerve stimulation in myasthenia gravis 1min after muscle activation is inferior to testing a second muscle at rest
Source:Clinical Neurophysiology, Volume 127, Issue 10
Author(s): Alon Abraham, Majed Alabdali, Abdulla Alsulaiman, Ari Breiner, Carolina Barnett, Hans D. Katzberg, Vera Bril
ObjectivesTo explore the increased diagnostic yield of repetitive nerve stimulation (RNS) following activation for myasthenia gravis (MG) diagnosis, and compare with testing an additional muscle at rest only.MethodsWe performed a retrospective chart review of patients diagnosed with MG attending the neuromuscular clinic from 2013 to 2015 and extracted data on electrophysiological studies, including frequency of decrement of 10% or above, with facial RNS at rest, and following activation.ResultsThe total cohort included 102 patients with MG, 65 with generalized, and 37 with ocular MG. Facial RNS sensitivities for diagnosing MG were 32–46% and 14–19% respectively. The increase in RNS sensitivity following muscle activation was 6–8% for frontalis muscle recordings, and 0–2% for nasalis muscle recordings. Recording from both muscles at rest only, increased the sensitivity by 9–15%.ConclusionRNS is a valid method for confirming a clinical diagnosis of MG. The increased diagnostic yield of RNS following activation is controversial. Our study shows that the increased diagnostic yield of facial RNS following activation is modest, and is less than performing facial RNS in a second muscle.SignificancePerforming facial RNS in an additional muscle at rest appears to be more sensitive than facial RNS in a single muscle after activation.
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Ultrasonographic assessment of superficial fibular nerve branches
Source:Clinical Neurophysiology, Volume 127, Issue 10
Author(s): Daniele Coraci, Andrea Faiola, Ilaria Paolasso, Alberto Battaglia, Valter Santilli, Luca Padua
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Homozygous KCNMA1 mutation as a cause of cerebellar atrophy, developmental delay and seizures
Abstract
Dominant gain-of-function mutations of the KCNMA1 gene, encoding the pore-forming subunit of the large conductance voltage- and Ca2+-activated K+ channel, have been described in a few patients with the syndrome of epilepsy, paroxysmal dyskinesias and developmental delay. In this report, we describe the loss-of-function phenotype of this newly described disease gene. In two siblings from a consanguineous family with epilepsy, developmental delay and severe cerebellar atrophy, combined exome/autozygome analysis identified a homozygous frameshift duplication in KCNMA1 (c.2026dupT; p. (Tyr676 Leufs*7)) in both children. Our report defines a novel autosomal recessive KCNMA1-related epileptic phenotype that encompasses cerebellar atrophy without paroxysmal dyskinesia, and highlights the sensitivity of the developing brain to both increased and decreased activity of the KCNMA1-encoded channels.
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Writing a Case Report: The Opening Challenge
2016-08-27T08-34-45Z
Source: Journal of Behavioral Health
S.M. Yasir Arafat.
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Study of Complementary and Alternative Medicine Usage of Cancer Patients Receiving Medical Oncology Clinic Medicine and Its Relationship with Their Quality of Life
2016-08-27T08-34-45Z
Source: Journal of Behavioral Health
Elif Temucin, Tulay Ortabag.
Background: This study has been implemented with the aim of examining the situation and the quality of life of cancer patients receiving treatment at an oncology clinic and using complementary and alternative medicine (CAM). Methods: Research has been carried out with 85 colorectal and lung cancer patients and was conducted from March 23 to May 1, 2011. The Introductory Information Form, Question Form for the Status of Using CAM and "Rotterdam Symptom Checklist" have been used as data collection tools. Results: It has been found in this study that the rate of cancer patients using CAM was 51,8%. The most popular CAM method was herbal cures. In our research, we found that CAM was used in the young age groups with a high level of education, in patients in the third phase of the disease and in the women. It has also been found that patients were informed by their close environment, and they were reluctant to disclose the CAM method they use to a health care professional. Most of the patients using CAM intended to increase their body strength. When assessed the quality of life of cancer patients using and not using CAM was not statistically different as determined by their physical, psychological, and daily life activities. Conclusion: It is of the utmost important for the nurses providing primary care for the cancer patients in the implementation of conventional treatment, to be able to make assessments about the usage of CAM by patients and provide appropriate advice.
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The United States National Physical Activity Plan: Is it Being Integrated into Exercise Science Curriculum
2016-08-27T08-34-45Z
Source: Journal of Behavioral Health
Allison Nooe, Paul D. Loprinzi.
Purpose: No research has evaluated the extent to which exercise science graduate curriculum incorporates content from the National Physical Activity Plan (NPAP). The purpose of this study was to examine awareness and utilization of the NPAP among university faculty. Methods: A population-based cross-sectional study design was employed that surveyed University exercise science faculty; 60 Universities granting a doctoral degree in Kinesiology were sampled, with 13 ultimately providing data for this study. Three sectors within the NPAP were evaluated, which included: health care; education; and transportation, land use and community design. Results: One-hundred percent of evaluated faculty reported awareness of the U.S. NPAP. With regard to the Health Care and Education strategies, 100% included at least one strategy and 85% included at least one Transportation, Land Use, and Community Design strategy. The percentages indicating use of all strategies in each sector was much lower with 39% of institutions reporting use of all Health Care strategies, 23% reported use of all Education strategies, and 38% reporting use of all Transportation, Land Use, and Community Design strategies. Conclusion: Our findings demonstrate that while awareness of the NPAP among faculty is high, implementation is much lower.
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Imaging of Occupational Lung Disease
Publication date: Available online 27 August 2016
Source:Radiologic Clinics of North America
Author(s): Jay Champlin, Rachael Edwards, Sudhakar Pipavath
Teaser
Occupational lung diseases span a variety of pulmonary disorders caused by inhalation of dusts or chemical antigens in a vocational setting. Included in these are the classic mineral pneumoconioses of silicosis, coal worker's pneumoconiosis, and asbestos-related diseases as well as many immune-mediated and airway-centric diseases, and new and emerging disorders. Although some of these have characteristic imaging appearances, a multidisciplinary approach with focus on occupational exposure history is essential to proper diagnosis.from Radiology via xlomafota13 on Inoreader http://ift.tt/2c3RLBx
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Higher resting heart rate variability predicts skill in expressing some emotions
Abstract
Vagally mediated heart rate variability (vmHRV) is a measure of cardiac vagal tone, and is widely viewed as a physiological index of the capacity to regulate emotions. However, studies have not directly tested whether vmHRV is associated with the ability to facially express emotions. In extending prior work, the current report tested links between resting vmHRV and the objectively assessed ability to facially express emotions, hypothesizing that higher vmHRV would predict greater expressive skill. Eighty healthy women completed self-reported measures, before attending a laboratory session in which vmHRV and the ability to express six emotions in the face were assessed. A repeated measures analysis of variance revealed a marginal main effect for vmHRV on skill overall; individuals with higher resting vmHRV were only better able to deliberately facially express anger and interest. Findings suggest that differences in resting vmHRV are associated with the objectively assessed ability to facially express some, but not all, emotions, with potential implications for health and well-being.
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Equity focused health impact assessment: social determinants of health
2016-08-27T04-28-32Z
Source: International Journal of Community Medicine and Public Health
Hassan N. Ayyoub.
Addressing health disparities during planning and delivery of services in health care requires an understanding of the health requirements of the disadvantaged population as well as key barriers to equitable quality care. To gain knowledge in social determinant of health it is important to have effective planning tools. Over the past two decades there has been continuous use of health impact assessment (HIA) to assess the health impacts of proposals, programs, policies, projects and even plans. The major problem affecting the implementation of HIA is the identification of the health issues in a policy since it depends on the judgment and the interpretation of the policy aspects by policy makers. The equity focused HIA has an opportunity to make important contributions to policy making processes. The main purpose of EFHIA (Equity Focused Health Impact Assessment) is to ensure that policies, plans, and programs being developed or proposed have observed health equity in order to promote social health.
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Development of a Data Abstraction Form: Getting What You Need From the Electronic Health Record
The electronic health record (EHR) serves a variety of purposes for the health care provider, including documentation of care; ensuring communication, safety, and quality of care; legal documentation; and research- and evidence-based practice. The Agency for Healthcare Research and Quality (2016) notes that the EHR has been effective in transforming the quality, safety, and efficiency of care delivery in health care. In our previous work, we noted that much of the focus of the EHR is on data entry by the health care provider; however, data can also be abstracted for the purposes of research and quality improvement (Spratling & Powers, 2015).
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Novel miniature inverted-repeat transposable elements derived from novel CACTA transposons were discovered in the genome of the ant Camponotus floridanus
Abstract
Fourteen novel miniature inverted-repeat transposable element (MITE) families are found in the Florida carpenter ant genome, Camponotus floridanus. They constitute approximately 0.63 % of the entire genome. Analysis of their insertion time showed that most members of these MITEs were inserted into their host genome in less than 8 million years ago. In addition, the association between MITEs and the noncoding regions of genes in C. floridanus is random. Interestingly, an autonomous partner (named CfTEC) responsible for the amplification of these MITEs was also found in C. floridanus. Meanwhile, we present evidence, based on searches of publicly available databases, that this autonomous element was widespread in animals. Moreover, structure and phylogenetic analyses supported that TECs might represent a novel cade of transposons intermediate between the classic CACTA transposon and TRCs. Finally, their transposition mechanism and impact on host genome evolution were also discussed.
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Bowel strangulation caused by massive intraperitoneal adhesion due to effective chemotherapy for multiple peritoneal metastases originating from descending colon cancer
Abstract
We describe a case of bowel strangulation caused by massive peritoneal adhesion as a result of effective chemotherapy. A 71-year-old man, who had obstructive descending colon cancer with massive peritoneal metastases and, therefore, received palliative surgery consisting of diverting colostomy and sampling of peritoneal nodules, developed bowel strangulation on day 4 of the 2nd course of chemotherapy, including irinotecan, l-leucovorin, and 5-fluorouracil. Emergent celiotomy showed a massive intraperitoneal adhesion formed around several intestinal loops, which were not observed at the prior surgery. One loop was strangled, but recovered by adhesiotomy alone. Intestinal loops were formed around aggregates of peritoneal nodules as the centers, several of which were then sampled. We closed the abdomen after all intestinal loops were eradicated by total enterolysis. Fortunately, the patient has been doing well and received chemotherapy without recurrent bowel obstruction 10 months after the present episode. Histological findings of the aggregates causing intestinal loops demonstrated extensive necrosis of cancerous tissue surrounded by fibrosis with abundant lymphocyte infiltration. These findings were not observed in the specimen sampled before chemotherapy, suggesting that intestinal loops were caused by inflammatory adhesion occurring around the peritoneal metastases as a result of effectiveness of chemotherapy.
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Endoscopic peroral jejunal fecal microbiota transplantation
Fecal microbiota transplantation (FMT) is a valuable treatment modality for recurrent Clostridium difficile (C. difficile) colitis. Multiple questions including the best delivery route and volume remain unanswered. Here, we report a case series of high-volume FMT using endoscopic jejunal application route.
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Serum hepatocyte apoptosis biomarker predicts the presence of significant histological lesion in chronic hepatitis B virus infection
Hepatocyte death, either apoptosis or necrosis, is closely associated with hepatic inflammation and fibrosis.
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“Who” should be focused? The influence of focus status on pronoun resolution
Abstract
Focus is assumed to be able to enhance the salience of a focused constituent and thereby facilitate the interpretation of a pronoun that refers to a focused antecedent relative to an unfocused antecedent. To assess how discourse-based focus structure influences the interpretation of a pronoun and whether this process is modulated by the grammatical role of the antecedent, we conducted an ERP study in which the focus status of a pronoun's potential antecedents was manipulated by means of a wh-question-answer structure. We found that, relative to those in the focused position, pronouns referring to antecedents in the unfocused position evoked enhanced positive responses in both early (180–230 ms) and late time windows (400–800 ms). Moreover, while a larger positivity was evoked by object-referring pronouns compared to subject-referring pronouns in the 400–800 ms time window over the right hemisphere, there was no effect of grammatical role in the 180–230 ms time window. These findings indicate that, while the initial stage of pronoun resolution is modulated by focus information assigned via a wh-question structure, integration of the pronoun and its antecedent into a coherent discourse representation at the later stage could be constrained by various factors, including the focus status and possibly the grammatical role of the antecedent.
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Automatic emotion regulation in response inhibition: The temporal dynamics of emotion counter-regulation during a go/no-go task
Abstract
Recent behavioral studies indicate that emotion counter-regulation automatically allocates attention to events that are opposite in the valence to the experienced emotional state. The present study explored the effect of emotion counter-regulation on response inhibition by using ERPs in a go/no-go paradigm. We recruited 58 subjects and randomly assigned them to either the angry priming group (watching Nanjing Massacre movie clips) or the neutral priming group (watching "mending a computer" movie clips). The behavioral results revealed that participants in the angry priming group responded significantly more accurately to go happy and no-go angry faces than go angry and no-go happy faces. The analyses of ERPs revealed that the amplitudes of the no-go N2 and no-go P3 were significantly larger for the happy faces than for the angry faces in the angry priming group. However, no such effects were found in the neutral priming group. These results suggest that highly aroused angry emotion could prompt a priority response to happy emotion stimuli and restrict the responses to angry emotion stimuli through emotion counter-regulation.
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Expectancy affects the feedback-related negativity (FRN) for delayed feedback in probabilistic learning
Abstract
Learning from feedback is a prerequisite for adapting to the environment. Prediction error signals coded by midbrain dopamine (DA) neurons are projected to the basal ganglia and anterior cingulate cortex (ACC). It has been suggested that neuronal activity shifts away from the DA system when feedback is delayed. The feedback-related negativity (FRN), an ERP that is generated in the ACC and has been shown to be sensitive to feedback valence and prediction error magnitude, was found to be reduced for delayed feedback. It has, however, not yet been investigated if the FRN for delayed feedback reflects a reward prediction error. In this study, effects of feedback delay (1 s vs. 7 s) on the processing of expected and unexpected positive and negative feedback were investigated in a between-subjects design in healthy human participants conducting a probabilistic feedback learning task. FRN and P300 amplitudes were decreased for subjects learning from delayed compared to immediate feedback. Importantly, the FRN, extracted from the negative-positive feedback difference wave, was significantly smaller for expected compared to unexpected feedback for both the immediate and delayed feedback conditions. Expectancy effects for the P300 were also seen, but did not interact with feedback valence. These results demonstrate an influence of feedback expectancy, and thus the prediction error, on early feedback processing even for delayed feedback, suggesting that neuronal structures underlying feedback processing are comparable for immediate and delayed feedback, at least to some extent. Modulations of the P300 by feedback delay may be linked to feedback salience.
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Comparative study of the efficacy and safety of olopatadine eyedrops and sodium cromoglycate in clinical practice: a prospective study
2016-08-27T03-19-14Z
Source: International Journal of Basic & Clinical Pharmacology
Scandashree K, Meghana Patil, Padmaja Udaykumar.
Background: Allergic eye diseases are the commonest causes of ocular morbidity worldwide. To choose the best therapy in allergic conjunctivitis, understanding of underlying mechanisms implicated in triggering the allergy is very important. Olopatadine with a wide spectrum has proven to be very effective in allergic conjunctivitis. The objective of the study was to compare the efficacy and safety of ophthalmic solutions of olopatadine 0.2% once daily, olopatadine 0.1% twice daily and sodium cromoglycate 2% four times daily in allergic conjunctivitis for 3 weeks. Methods: This was a prospective, single centre study enrolling 304 patients with allergic conjunctivitis attending ophthalmology clinics. Subjects were assessed for ocular signs and symptoms at 3 visits-baseline, week 2, week 3. The change from baseline in the mean scores of itching and redness at 3 weeks was primary outcome variable. Results: The reduction in signs and symptoms were statistically significant in all the three groups (p
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Comparison of unilateral spinal anaesthesia using low dose bupivacaine with or without fentanyl in lower limb surgery
2016-08-27T03-19-14Z
Source: International Journal of Basic & Clinical Pharmacology
Vinod S. Jaiswal, Devendra W. Thakare.
Background: Intrathecal opioids are synergistic with local anesthetics and intensifies sensory block without increasing motor block. This combination makes it possible to achieve spinal anesthesia without hemodynamic instability and adverse effects that are associated with higher doses of bupivacaine. Hence we conducted this comparative study using 5 mg of hyperbaric bupivacaine with or without fentanyl (25 µg) in unilateral spinal anaesthesia for lower limb surgery. Methods: Sixty patients were randomized into two groups with Group B receiving 0.5% bupivacaine and Group BF receiving 0.5% bupivacaine + 25 µg fentanyl intrathecal. Sensory and motor block quality and duration, post anesthesia care unit stay (PACU) and adverse effects were compared. Results: The onset of sensory block (6.17±1.44) was faster in Group B compared Group BF (6.73±1.52) and duration of sensory blockade was intensified by addition of intrathecal fentanyl in Group BF. The onset and duration of motor blockade was similar in both the groups and was not affected by addition of fentanyl in Group BF. The number and mean duration stay in PACU was found to be significantly higher in patients 24 [80%]; 30 minutes receiving fentanyl suggesting it prolonged duration of recovery. No patient in either group had hypotension, respiratory depression, sedation, nausea, vomiting, PDPH and TNS. Only 1 patient in each group experienced bradycardia and 4 patients in Group BF had mild pruritus. Conclusions: Unilateral spinal anaesthesia with 5 mg hyperbaric bupivacaine with 25 µg fentanyl is a better choice than 5 mg hyperbaric bupivacaine alone in short procedure of lower limb in orthopaedic surgery.
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