Evaluating the Relationship Between Post Traumatic Stress Disorder Symptoms and Psychological Resilience in a Sample of Turkoman Refugees in Turkey

xloma.fota13 shared this article with you from Inoreader Evaluating the Relationship Between Post Traumatic Stress Disorder Symptoms and Psychological Resilience in a Sample of Turkoman Refugees in Turkey Via Latest Results for Journal of Immigrant and Minority Health Abstract Turkey has witnessed an increase in migration of people belonging to neighboring countries due to civil war. Traumatic life events experienced by refugees bring along mental problems. Their psychological resilience enables them to cope with these difficulties. In this study, 101 Iraqi Turkoman refugees who migrated to Turkey following the increasing civil war events in their country were evaluated psychologically. Sociodemographic data form Resilience Scale for Adults (RSA) and Clinician-Administered Post-Traumatic Stress Disorder Scale (CAPS) were used for psychological evaluation. The prevalence of lifetime post-traumatic stress disorder (PTSD) among the refugees was 25.7%. There was no significant difference between the psychological resilience of the patients who developed PTSD and those who did not (p = 0.709). As the severity of trauma decreased, psychological resilience increased in the people who developed PTSD (p = 0.001, r = −0.622). Consi dering the psychological resilience of refugees, the area with the highest resilience is access to social resources, while the area with the lowest is the planned future. It was observed that the basic needs of refugees after migration could not be met clearly compared to the ones before migration. It was noteworthy that in cases diagnosed with PTSD, CAPS scores increased (p = 0.011, r: 0.251) and resilience decreased (p < 0.001, r: −0.376) as the inability to reach basic needs increased. Our study is very important in terms of defining how refugees are mentally affected after settling in another country and what determines their psychological resilience. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Fixed full‐arch maxillary prostheses supported by four versus six implants with a titanium CAD/CAM milled framework: 3‐year multicentre RCT

xloma.fota13 shared this article with you from Inoreader Fixed full‐arch maxillary prostheses supported by four versus six implants with a titanium CAD/CAM milled framework: 3‐year multicentre RCT Via Clinical Oral Implants Research Abstract Objectives This RCT compares marginal bone level (MBL) change and the clinical parameters after a 3‐year function in maxillary implant‐supported fixed complete dentures (FCDs) treated with four‐implants(4‐I) or 6‐implants(6‐I). Material and method Three centres treated 56 patients with 280 implants allocated to the 4‐I or 6‐I group. Radiographic and clinical examinations were performed. The primary outcome was to investigate MBL change between the groups. Results Implant survival rates were 100% and 99% in the 4‐I and 6‐I groups, respectively. Considering the clustering effects, the MBL change was not significantly different between the groups over the 3‐year follow‐up. The MBL in the 4‐I group was 0.30±0.50mm at baseline, 0.24±0.31mm at 1‐year and 0.24±0.38mm at 3‐year. In the 6‐I group, MBL was 0.14±0.32mm at baseline, 0.16±0.35mm at 1‐year and 0.12±0.26 mm at 3‐year. There was a statistically significant difference between the groups at BL and 3Y. No significant differences between the groups were reported for clinical parameters at each time point as well as in between the visits. The technical and biological complications rates were 1.6% and 6.0%, respectively. Prosthetic complications affected 25 FCDs (47.2%). Conclusion MBL change revealed a stable condition in the 3‐year period in the two groups. Few technical and biological complications occurred apart from the chipping/fracture of the prosthetic teeth. Four‐implant is a feasible solution if the rehabilitation is oriented towards the most cost‐effective treatment and towards avoiding bone augmentation procedures. Clinicians have to consider the potential required visits for prosthetic maintenance. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Long‐term crestal bone changes in implants placed in augmented sinuses with minimal or moderate remaining alveolar bone. A 10‐year retrospective case series study

xloma.fota13 shared this article with you from Inoreader Long‐term crestal bone changes in implants placed in augmented sinuses with minimal or moderate remaining alveolar bone. A 10‐year retrospective case series study Via Clinical Oral Implants Research Abstract Objectives To evaluate long‐term clinical and radiographic outcomes of dental implants placed after lateral window sinus augmentation utilizing the sagittal sandwich technique. Materials and Methods Patients treated with sinus augmentation were included in this retrospective case series study. The surgical procedure was performed with particulate autogenous bone and anorganic bovine bone‐derived mineral (3:7 ratio). Implants were grouped based on baseline residual alveolar ridge height: group S (residual alveolar ridge height of 0.1‐3.5 mm), group M (height of 3.5‐7mm), and group C (native bone). Radiographs were taken at baseline (abutment installation) and annually throughout the 10‐year follow‐up. Results A total of 86 patients (92 sinus lifts) and 209 implants were included. Ten sinus membrane perforations were recorded (11% incidence) and graft infections occurred in 3 cases (3.2% incidence). During the 10‐year follow‐up, 3 implants (1.4%) failed. No significant differences in the mean implant marginal bone loss (MBL) between the three groups were found after 1, 2, and 5 years follow‐up (p>0.05). At 10 years, group C exhibited more MBL than group M with a mean difference of ‐0.53 mm (p=0.01). After 10 years, MK III implants displayed significantly more bone loss in native bone than those in augmented bone with a mean difference of 0.48 mm (p=0.02). Five patients and 7 implants developed peri‐implantitis with no significant differences between groups (p=0.570). Conclusion Implant placement after two‐stage sinus grafting utilizing the sagittal sandwich technique is a relatively safe and predictable procedure with minimal complications and MBL after 10‐years follow‐up. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Thermal effects of various drill materials during implant site preparation ‐ ceramic vs. stainless steel drills: A comparative in vitro study in a standardised bovine bone model

xloma.fota13 shared this article with you from Inoreader Thermal effects of various drill materials during implant site preparation ‐ ceramic vs. stainless steel drills: A comparative in vitro study in a standardised bovine bone model Via Clinical Oral Implants Research Abstract Objectives The aim of this study was to evaluate thermal effects of ceramic and metal implant drills during implant site preparation using a standardised bovine model. Material and Methods A total of 320 automated intermittent osteotomies of 10‐ and 16‐mm drilling depths were performed using zirconium‐dioxide‐based and stainless steel drills. Various drill diameters (2.0 / 2.2, 2.8, 3.5, 4.2 mm ∅) and different cooling methods (without / with external saline irrigation) were investigated at room temperature (21 ± 1°C). Temperature changes were recorded in real‐time using 2 custom‐built multichannel thermoprobes in 1‐ and 2‐mm distance to the osteotomy site. For comparisons a linear mixed model was estimated. Results Comparing thermal effects, significantly lower temperatures could be detected with steel‐based drills in various drill diameters, regardless of drilling depth or irrigation method. Recorded temperatures for metal drills of all diameters and drilling depths using external irrigation were below the defined critical temperature threshold of 47°C, whereas ceramic drills of smaller diameters reached or exceeded the harmful temperature threshold at 16‐mm drilling depths, regardless of whether irrigation was applied or not. The results of this study suggest that the highest temperature changes were not found at the deepest point of the osteotomy site but were observed at subcortical and deeper layers of bone, depending on drill material, drill diameter, drilling depth and irrigation method. Conclusions This standardised investigation revealed drill material and geometry to have a substantial impact on heat generation, as well as external irrigation, drilling depth and drill diameter. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The comparative evaluation of transcrestal and lateral sinus floor elevation in sites with residual bone height ≤ 6mm: A two‐year prospective randomized study

xloma.fota13 shared this article with you from Inoreader The comparative evaluation of transcrestal and lateral sinus floor elevation in sites with residual bone height ≤ 6mm: A two‐year prospective randomized study Via Clinical Oral Implants Research Abstract Objectives To compare clinical and radiographic outcomes between transcrestal sinus floor elevation (TSFE) and lateral sinus floor elevation (LSFE) approaches of simultaneous implant placement in atrophic maxilla. Materials and Methods Patients with a residual bone height (RBH) ≤6 mm were enrolled and randomly assigned to TSFE and LSFE groups. Patients in both groups simultaneously underwent sinus floor elevation with bovine‐derived xenograft and implant placement. Clinical and radiographic results were evaluated immediately after surgery and after 6, 12, 18, and 24 months. The endo‐sinus bone gain (ESBG), apical implant bone height (ABH), endo‐sinus bone‐implant contact rate (EBICR), and crestal bone level (CBL) were assessed using panoramic radiographs. Results Forty‐one implants (TSFE: 21, LSFE: 20) were placed in cases with a mean RBH of 3.77 ±1.16 mm. All implants obtained clinical success and satisfactory ESBG at 24 months. No significant differences were found in ESBG and ABH between two groups immediately after surgery, but LSFE group showed significantly higher values than TSFE group thereafter. Grafts in TSFE group reached stability 6 months earlier than that in LSFE group. In both groups, EBICR was almost 100%, and CBL showed no detectable changes. Conclusions LSFE can achieve higher ESBG 2 years after surgery. Otherwise, TSFE could be an alternative to LSFE, when the access for lateral window preparation is limited. Both approaches were highly predictable for RBH ≤6 mm during 24‐month observation period for the implants placed simultaneously. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Case and Review: Cutaneous Involvement by Chronic Neutrophilic Leukemia versus Sweet Syndrome, a Diagnostic Dilemma

xloma.fota13 shared this article with you from Inoreader Case and Review: Cutaneous Involvement by Chronic Neutrophilic Leukemia versus Sweet Syndrome, a Diagnostic Dilemma Via Journal of Cutaneous Pathology Abstract Chronic neutrophilic leukemia (CNL) is a rare leukemia with approximately 150 total cases reported. Cutaneous neutrophilic infiltrates, including Sweet syndrome (SS) and leukemia cutis (LC), have been reported in six patients with CNL. In the setting of CNL, these two conditions are difficult to differentiate due to clinical and histological similarities, but it is important to do so because leukemia cutis is associated with a worse prognosis. In general, Sweet syndrome is distinguished by its tenderness, fever, and improvement with steroids (vs chemotherapy for LC). Biopsy of LC reveals immature leukocytes, whereas SS shows almost exclusively mature leukocytes, but morphology alone may not be sufficient in some cases. Here we report a case of a 72‐year‐old male with CNL and a cutaneous eruption with clinical and pathologic features which made the distinction between the two diseases difficult. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR‐383/RP105/AKT signalling pathway

xloma.fota13 shared this article with you from Inoreader Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR‐383/RP105/AKT signalling pathway Via Journal of Cellular and Molecula... Abstract miRNA‐mediated pyroptosis play crucial effects in the development of myocardial ischaemia/reperfusion (I/R) injury (MIRI). Piperine (PIP) possesses multiple pharmacological effects especially in I/R condition. This study focuses on whether PIP protects MIRI from pyroptosis via miR‐383‐dependent pathway. Rat MIRI model was established by 30 minutes of LAD ligation and 4 hours of reperfusion. Myocardial enzymes, histomorphology, structure and function were detected to evaluate MIRI. Recombinant adenoviral vectors for miR‐383 overexpression or miR‐383 silencing or RP105 knockdown were constructed, respectively. Luciferase reporter analysis was used to confirm RP105 as a target of miR‐383. Pyroptosis‐related markers were measured by Western blotting assay. The results showed that I/R provoked myocardial injury, as shown by the increases of LDH/CK releases, infarcted areas and apoptosis as well as worsened function and structure. Pyroptosis‐related mediators i ncluding NLRP3, cleaved caspase‐1, cleaved IL‐1β and IL‐18 were also reinforced after MIRI. However, PIP treatment greatly ameliorated MIRI in parallel with pyroptotic repression. In mechanistic studies, MIRI‐caused elevation of miR‐383 and decrease of RP105/PI3K/AKT pathway were reverted by PIP treatment. Luciferase reporter assay confirmed RP105 as a miR‐383 target. miR‐383 knockdown ameliorated but miR‐383 overexpression facilitated pyroptosis and MIRI. Moreover, the anti‐pyroptotic effect from miR‐383 silencing was verified to be relied on the RP105/PI3K/AKT signalling pathway. Additionally, our present study further indicated the miR‐383/RP105/AKT‐dependent approach resulting from PIP administration against pyroptosis in MIRI. Therefore, PIP treatment attenuates MIRI and pyroptosis by regulating miR‐383/RP105/AKT pathway, and it may provide a therapeutic manner for the treatment of MIRI. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hypoxic bone marrow mesenchymal cell‐extracellular vesicles containing miR‐328‐3p promote lung cancer progression via the NF2‐mediated Hippo axis

xloma.fota13 shared this article with you from Inoreader Hypoxic bone marrow mesenchymal cell‐extracellular vesicles containing miR‐328‐3p promote lung cancer progression via the NF2‐mediated Hippo axis Via Journal of Cellular and Molecula... Abstract Lung cancer is the most aggressive tumour afflicting patients on a global scale. Extracellular vesicle (EV)‐delivered microRNAs (miRs) have been reported to play critical roles in cancer development. The current study aimed to investigate the role of hypoxic bone marrow mesenchymal cell (BMSC)‐derived EVs containing miR‐328‐3p in lung cancer. miR‐328‐3p expression was determined in a set of lung cancer tissues by RT‐qPCR. BMSCs were infected with lentivirus‐mediated miR‐328‐3p knock‐down and then cultured in normoxic or hypoxic conditions, followed by isolation of EVs. Following ectopic expression and depletion experiments in lung cancer cells, the biological functions of miR‐328‐3p were analysed using CCK‐8 assay, flow cytometry and Transwell assay. Xenograft in nude mice was performed to test the in vivo effects of miR‐328‐3p delivered by hypoxic BMSC‐derived EVs on tumour growth of lung cancer. Finally, the expression of circulating miR‐328� �3p was detected in the serum of lung cancer patients. miR‐328‐3p was highly expressed in EVs derived from hypoxic BMSCs. miR‐328‐3p was delivered to lung cancer cells by hypoxic BMSC‐derived EVs, thereby promoting lung cancer cell proliferation, invasion, migration and epithelial‐mesenchymal transition. miR‐328‐3p targeted NF2 to inactivate the Hippo pathway. Moreover, EV‐delivered miR‐328‐3p increased tumour growth in vivo. Additionally, circulating miR‐328‐3p was bioactive in the serum of lung cancer patients. Taken together, our results demonstrated that hypoxic BMSC‐derived EVs could deliver miR‐328‐3p to lung cancer cells and that miR‐328‐3p targets the NF2 gene, thereby inhibiting the Hippo pathway to ultimately promote the occurrence and progression of lung cancer. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

CircSAMD4A aggravates H/R‐induced cardiomyocyte apoptosis and inflammatory response by sponging miR‐138‐5p

xloma.fota13 shared this article with you from Inoreader CircSAMD4A aggravates H/R‐induced cardiomyocyte apoptosis and inflammatory response by sponging miR‐138‐5p Via Journal of Cellular and Molecula... Abstract Hypoxia/reoxygenation (H/R)‐induced myocardial cell injury is the main cause of acute myocardial infarction (AMI). Many proofs show that circular RNA plays an important role in the development of AMI. The purpose of this study was to investigate the role of circSAMD4A in H/R‐induced myocardial injury. The levels of circular SAMD4A (circSAMD4A) were detected in the heart tissues of AMI mice and H/R‐induced H9C2 cells, and the circSAMD4A was suppressed in AMI mice and H/R‐induced H9C2 cells to investigate its' function in AMI. The levels of circSAMD4A and miR‐138‐5p were detected by real‐time quantitative PCR, and MTT assay was used to detect cell viability. TUNEL analysis and Annexin V‐FITC were used to determine apoptosis. The expression of Bcl‐2 and Bax proteins was detected by Western blot. IL‐1β, TNF‐α and IL‐6 were detected by ELISA kits. The study found that the levels of circSAMD4A were up‐regulated after H/R induction and inhibition of circSAMD 4A expression would reduce the H/R‐induced apoptosis and inflammation. MiR‐138‐5p was down‐regulated in H/R‐induced H9C2 cells. circSAMD4A was a targeted regulator of miR‐138‐5p. CircSAMD4A inhibited the expression of miR‐138‐5p to promote H/R‐induced myocardial cell injury in vitro and vivo. In conclusion, CircSAMD4A can sponge miR‐138‐5p to promote H/R‐induced apoptosis and inflammatory response. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Immunoexpression of BDNF, TrkB and p75NTR receptors in peripheral neural lesions of the head and neck

xloma.fota13 shared this article with you from Inoreader Immunoexpression of BDNF, TrkB and p75NTR receptors in peripheral neural lesions of the head and neck Via Oral Pathology & Medicine Abstract Background Brain‐derived neurotrophic factor (BDNF) and neurotrophin receptors have been recognized as fundamental regulators of normal brain development, homeostasis and plasticity. They have also been studied in the behavior of central nervous system tumors. Here we studied the pattern of BDNF, TrkB and p75NTR immunoexpression in peripheral benign and malignant neural lesions in head and neck. Methods This cross‐sectional analytical study included 79 cases of head and neck neural lesions. Nineteen cases of traumatic neuromas (TN), 20 cases of granular cell tumors (GCT), 16 cases of neurofibromas (NF), 20 cases of schwannomas (SC) and 4 malignant peripheral nerve sheath tumour (MPNST) were submitted to immunohistochemistry with BDNF, TrkB and p75NTR antibodies. A semi‐quantitative analysis was performed. Results The analysis of BDNF demonstrated a high percentage of positive cells in TN, GCT and SC with a decrease in cases of NF and MPNST. TrkB presented a lower significant immunoexpression in GCT in relation to the TN, NF, SC and MPNST (p < 0.0001); and TN showed less percentage of positive cell compared to SC (p = 0.0017). Regarding p75NTR, the percentage of positive cell was significantly reduced in MPNST compared GCT (p = 0.009), NF (p = 0.0138) and SC (p = 0.0069). Also, a decrease in TN compared to GCT (p = 0.007) were observed. Conclusions Our results showed the immunoreactivity of BDNF, TrkB and p75NTR in head and neck peripheral neural lesions. Reduction of BDNF and p75NTR in MPNST might suggest downregulation during the acquisition of malignant phenotype. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

RhoA/ROCKs signalling is increased by treatment with TKI‐258 and leads to increased apoptosis in of SCC‐4 oral squamous cell carcinoma cell line

xloma.fota13 shared this article with you from Inoreader RhoA/ROCKs signalling is increased by treatment with TKI‐258 and leads to increased apoptosis in of SCC‐4 oral squamous cell carcinoma cell line Via Oral Pathology & Medicine Abstract Background This study evaluated the effect of treatment with TKI‐258 on apoptosis, involving Rho GTPases and their effectors in SCC‐4 cells of oral squamous cell carcinoma. Methods Markers of cell death and apoptosis were analyzed in control and TKI‐258 treated SCC‐4 cells by flow cytometry. The involvement of Rho GTPases and effectors in the induction of apoptosis by TKI‐258 was evaluated by quantification of cleaved PARP. Also gene expression analysis of those proteins was performed. Results The treatment with TKI‐258 led to a significant increase in cell death (7‐AAD) and apoptosis (Annexin V and cleaved PARP). When Rho GTPases were stimulated with LPA and inhibited with Toxin A Clostridium difficile, the percentage of apoptotic cells increased and decreased, respectively. A similar effect was found when the treatment was with TKI‐258 combined with LPA and Toxin A. Treatment with TKI‐258 significantly increased RhoA gene expression, while RhoB, RhoC, Rac1 and Cdc42 decreased significantly. ROCKs inhibitors (Y‐27632 and HA‐1077) reduced apoptosis compared with control. TKI‐258 combined with Y‐27632 or HA‐1077 led to an increase in apoptosis compared with inhibitors only. Treatment with TKI‐258 led to an increase in ROCK1 and ROCK2 gene expression, and a decrease in PAK1 and PAK2 gene expression. Conclusions TKI‐258 stimulates apoptosis in SCC‐4 cells of oral squamous cell carcinoma. Possibly, RhoA GTPase and their effectors ROCKs participate in the signalling pathway inhibited by TKI‐258. Clinical Relevance: Therapies with multi‐target inhibitors, such as TKI‐258, may be promising alternatives for the clinical treatment of oral squamous cell carcinoma. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

miRNA for the assessment of lymph node metastasis in patients with oral squamous cell carcinoma: systematic review and metanalysis

xloma.fota13 shared this article with you from Inoreader miRNA for the assessment of lymph node metastasis in patients with oral squamous cell carcinoma: systematic review and metanalysis Via Oral Pathology & Medicine Abstract Background MiRNA is one of the advanced epigenetic molecular markers correlating with lymph node metastasis in patients with OSCC. Numerous published papers are showing correlation of miRNA with metastasis. There is a need to analyze and validate such correlation Method English language literature in major databases from the last 20 years was searched using controlled vocabulary and keywords. Strict inclusion and exclusion criterias were followed for selection of studies. The quality assessment was done as per the QUADAS tool 2 by three independent reviewers. The metanalysis was performed by using random effect model. Standardized Mean Difference (SMD) was considered as the effect measure. Statistical software used was STATA version 13.1. Results With all inclusion and exclusion criteria, eight studies could qualify for metanalysis. The pooled estimate is found to be 0.13 (‐0.35, 0.62), P=0.585, which is statistically not significant. This indicates that there is a no significant difference in the fold change between metastasis and no metastasis groups. P‐value of Chi‐square statistic for heterogeneity is <0.001 (significant) and I‐squared statistic is 87.2%, which indicates that heterogeneity is present to a considerable extent. Egger's test shows there is no publication bias involved (P=0.819). Conclusion The metanalysis showed no significant difference in the fold change of miRNA expression between metastasis and non metastasis OSCC patients. Future studies can be directed to eliminate the heterogeneity among the studies noted in this analysis to confirm the role of miRNA for assessment of regional metastasis with special focus on tongue squamous cell carcinoma. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.