Cirrhotic patients with hepatocellular carcinoma (HCC) exhibit hypercoagulability.
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Δευτέρα 26 Δεκεμβρίου 2016
Thromboelastometry hypercoagulable profiles and portal vein thrombosis in cirrhotic patients with hepatocellular carcinoma
Thromboelastometry hypercoagulable profiles and portal vein thrombosis in cirrhotic patients with hepatocellular carcinoma
Cirrhotic patients with hepatocellular carcinoma (HCC) exhibit hypercoagulability.
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EFFECT OF FEEDING BYPASS PROTEIN FEED ON MILK PRODUCTION, COMPOSITION AND RETURN OVER FEED COST FROM BUFFALOES OF TRIBAL AREAS IN PANCHMAHAL AND VADODARA DISTRICTS
2016-12-26T22-02-06Z
Source: International Journal of Livestock Research
Chanchal Raghuraj Singh Waghela, Subhash Parnerkar, Makarand Barbadikar.
The study involving eighty buffaloes in their second to fourth lactation in Panchmahal and Vadodara districts indicated that during early lactation inclusion of concentrate mixture with bypass protein in the ration resulted in significant improvement in yield of whole milk, fat and 6% Fat Corrected Milk (FCM). The improved feed conversion efficiency in treatment group resulted in higher return over feed cost. The farm animals in 15-60 days post-partum period were selected based on their average daily milk yield and fat per cent following Completely Randomized Design, for the trial of 90 days duration at tribal villages in Panchmahal and Vadodara districts. The selected buffaloes were randomly allotted to two dietary treatments i.e. T1 (Control) and T2 (Bypass protein feed). The buffaloes in control group (T1) were fed as per the feeding schedule followed by the farmers (concentrate + green roughage + dry roughage) and those in treatment group (T2) were reared on farm feeding schedule + compound concentrate mixture containing bypass protein. The inclusion of bypass protein feed in early lactating buffaloes resulted in improvement in milk quantity and quality as well as feed conversion efficiency which led to increase in daily income by Rs. 29.18 ± 5.18 and 29.53 ± 7.33 per buffalo in Panchmahal and Vadodara districts, respectively.
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Four-week cold acclimation in adult humans shifts uncoupling thermogenesis from skeletal muscles to BAT
Abstract
We previously showed that four weeks of daily cold exposure, in humans, can increase brown adipose tissue (BAT) volume by 45% and oxidative metabolism by 182%. Surprisingly, we did not find a reciprocal reduction in shivering intensity when exposed to a mild cold (18°C). The aim of the present study was to determine whether changes in skeletal muscle oxidative metabolism or shivering activity could account for these unexpected findings. Nine men participated in a four-week cold acclimation intervention (10°C water circulating in liquid-conditioned suit, 2 h/day, 5 days/week). Shivering intensity and pattern were measured continuously during a controlled cold exposure (150 min at 4°C) before and after the acclimation. Muscle biopsies from m. vastus lateralis were obtained to measure oxygen consumption rate and proton leak of permeabilized muscle fibers. Cold acclimation elicited a modest 21% (P < 0.05) decrease in whole-body and m.vastus lateralis shivering intensity. Further, cold acclimation abolished the acute cold-induced increase in proton leak. Although daily cold exposure did not change the fiber composition of the m. vastus lateralis, fiber composition was a strong predictor of the shivering pattern evoked during an acute cold. We conclude that muscle-derived thermogenesis during acute cold exposure in humans is not limited to shivering, but also includes cold-induced increases in proton leak. The efficiency of muscle oxidative phosphorylation improves with cold acclimation, suggesting that reduced muscle thermogenesis occurs through decreased proton leak, in addition to decreased shivering intensity as BAT capacity and activity increases. These changes occur with no net difference in whole-body thermogenesis.
This article is protected by copyright. All rights reserved
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Characterizing the sympatholytic role of endothelial-dependent vasodilator signalling during handgrip exercise
Abstract
The dynamic metabolic range of skeletal muscle necessitates an equally dynamic blood flow requirement, to the point where the demand for skeletal muscle blood flow during intense bouts of large muscle mass exercise can theoretically 'outstrip' the heart's ability to generate the cardiac output necessary for maintaining sufficient mean arterial pressure (MAP) and muscle perfusion.
This article is protected by copyright. All rights reserved
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What do we know of Roman wall painting technique? Potential confounding factors in ancient paint media analysis
The theory of fresco as the standard painting technique in Roman wall paintings, formulated in the mid-1960s by Paolo Mora and Laura Mora and Paul Philippot, has enjoyed general acceptance among specialists to the present day. However, the fresco theory is based on a series of postulates—such as the feasibility of fresco on pontate, the presence of giornate, or the use of alkali-sensitive pigments—which appear to be unsupported by physical or experimental evidence and which would require further assessment in order to validate the theory. Additionally, chemical analyses of Roman murals have identified the presence of various types of organic binders. A comparative study of these analyses reveals a remarkable difference between results obtained by the different researchers. The clustering of results by research group appears highly unlikely, suggesting the possible presence of confounding factors which could lead to distorted results. These factors might be related both to the difficulty in extracting ancient paint media and the influence of biological contamination. If the extraction method used is not adequate for an ancient binding medium, then part of the binder may not be extracted, producing an incomplete characterization of its composition. The lack of data on both the efficiency of the methods used and the possible influence of microbial contamination in the organic material may cause uncertainty in the degree of reliability of the different results obtained, fomenting uncertainty around the techniques used in ancient paintings as well as the treatments suitable for their conservation. Therefore, in the analysis of ancient paint media, the implementation of a protocol of assessment of both the efficiency of the extraction methods and the influence of biological contamination seems advisable.Graphical abstract.
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Health behavioral theories used to explain dietary behaviors in adolescents: a systematic review
Background: Health behavior theories are useful to interpret adolescents' dietary behaviors. Evidences show that theories are influenced by social and psychological determinants. So, the purpose of this study is to systematically review studies that tested social cognitive theories (non-integrated) that predict adolescents' dietary behaviors. Methods: A structured electronic search of all publication years (through April 2016) was conducted to identify studies in MEDLINE, SciELO, PsycINFO, Scopus, and LILACS with full text. Included publications were cross-sectional and longitudinal (non-intervention) studies involving adolescents (10 to 18 years) that examined the associations between constructs of social-cognitive theories and dietary behaviors. Related strings in titles, abstracts, and indexing fields were searched. Results: Theories used to explain dietary intake were the planned behavior and the social cognitive. It was observed evidences of positive associations between the social cognitive constructs and the fruits, the vegetables, the milk groups, and the whole-wheat foods (e.g., bread rich in fiber) and negative associations with sugar-sweetened beverages, soft drinks, snacks high in fat, sugar, and/or sodium, and sweet treats. Theories explained greater proportion of variance for intention to dietary intake. The variance for intention ranged from 3% for pizzas, candy bars, candies, and sugar-sweetened beverages to 68% for whole-wheat food (i.e., bread rich in fiber). Conclusion: Longitudinal designs are necessary to comprehend the theories and evaluate the behavioral changes. Finally, the use of food groups should be employed in the studies to help the comparisons and present higher reproducibility. Studies always based on objective, systematic, and rigorous evidences.
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The effect of a Live-high Train-high exercise regimen on behavioural temperature regulation
Abstract
Purpose
Acute hypoxia alters the threshold for sensation of cutaneous thermal stimuli. We hypothesised that hypoxia-induced alterations in cutaneous temperature sensation may lead to modulation of the perception of temperature, ultimately influencing behavioural thermoregulation and that the magnitude of this effect could be influenced by daily physical training.
Methods
Fourteen men were confined 10 days to a normobaric hypoxic environment (PIO2 = 88.2 ± 0.6 mmHg, corresponding to 4175 m elevation). Subjects were randomly assigned to a non-exercising (Live-high, LH, N = 6), or exercising group (Live-high Train-high, LH-TH, N = 8) comprised of 1-h bouts of cycle ergometry, twice daily, at a work-rate equivalent to 50% hypoxic peak power output. A subset of subjects (N = 5) also completed a control trial under normoxic conditions. The thermal comfort zone (TCZ) was determined in normoxia, and during hypoxic confinement days 2 (HC2) and 10 (HC10) in both groups using a water-perfused suit in which water temperature was regulated by the subjects within a range, they deemed thermally comfortable. Mean skin temperature and proximal–distal temperature gradients (two sites: forearm-fingertip, calf-toe) were recorded each minute throughout the 60-min protocol.
Results
The average width of the TCZ did not differ between the control group (9.0 ± 6.9 °C), and the LH and LH-TH groups on days HC2 (7.2 ± 4.2 °C) and HC10 (10.2 ± 7.5 °C) of the hypoxic exposure (p = 0.256). \(\bar{T}_{\text{SK}}\) was marginally higher on HC2 (35.9 ± 1.0 °C) compared to control (34.9 ± 0.8 °C, p = 0.040), but not on HC10 (35.6 ± 1.0 °C), reflecting the responses of hand perfusion.
Conclusion
There was a little systematic effect of hypoxia or exercise training on TCZ magnitude or boundary temperatures.
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Soluble Syndecan-1: A Novel Biomarker of Small Bowel Mucosal Damage in Children with Celiac Disease
Abstract
Background
Syndecan-1 (SDC1) is essential for maintaining normal epithelial barrier. Shedding of SDC1 ectodomain, reflected by serum soluble syndecan-1 (SSDC1) levels, is regulated by inflammation. Increased intestinal permeability plays a central role in celiac disease (CD). The association between SSDC1 levels and mucosal damage in CD has not been evaluated.
Aims
To evaluate serum SSDC1 levels in children with CD and to determine its relationship with histological grading classified by modified Marsh criteria.
Methods
This is a cross-sectional, pilot study, in which serum SSDC1 was analyzed by ELISA in a cohort of 49 untreated children with CD and 15 children with nonspecific abdominal pain (AP). CD was diagnosed based on positive celiac serology and small intestinal biopsy. SSDC1 levels at the time of biopsy were correlated with Marsh grading. Controls were defined by AP, negative celiac serology, normal upper endoscopy, and small intestinal biopsies.
Results
SSDC1 levels were significantly higher in CD patients compared to AP controls (116.2 ± 161 vs. 41.3 ± 17.5 ng/ml, respectively, p < 0.01). SSDC1 levels were significantly higher in patients with Marsh 3c lesion compared to AP controls (170.6 ± 201 vs. 41.3 ± 17.5 ng/ml, respectively, p < 0.05). SSDC1 concentrations displayed a significant correlation with mucosal damage defined by Marsh (r = 0.39, p < 0.05).
Conclusion
This is the first study demonstrating elevated levels of serum SSDC1 in children with CD. Our results suggest that SSDC1 is a potentially novel marker of intestinal mucosal damage in patients with CD. Its applicability as a surrogate biomarker in CD remains to be determined.
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MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells
Abstract
Background
Warburg effect is a hallmark of cancer cells. Accumulating evidence suggests that microRNAs (miRs) could regulate such metabolic reprograming. Aberrant expression of miR-98 has been observed in many types of cancers. However, its functions and significance in colon cancer remain largely elusive.
Aims
To investigate miR-98 expression and the biological functions in colon cancer progression.
Methods
miR-98 expression levels were determined by quantitative RT-PCR in 215 cases of colon cancer samples. miR-98 mimic or inhibitor was used to test the biological functions in SW480 and HCT116 cells, followed by cell proliferation assay, lactate production, glucose uptake, and cellular ATP levels assay and extracellular acidification rates measurement. Western blot and luciferase assay were used to identify the target of miR-98.
Results
miR-98 was significantly down-regulated in colon cancer tissues compared to adjacent colon tissues and acted as a suppressor for Warburg effect in cancer cells. miR-98 inhibited glycolysis by directly targeting hexokinase 2, or HK2, illustrating a novel pathway to mediate Warburg effect of cancer cells. In vitro experiments further indicated that HK2 was involved in miR-98-mediated suppression of glucose uptake, lactate production, and cell proliferation. In addition, we detected HK2 expression in colon cancer tissues and found that the expressions of miR-98 and HK2 were negatively correlated.
Conclusion
miR-98 acts as tumor suppressor gene and inhibits Warburg effect in colon cancer cells, which provided potential targets for clinical treatments.
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Gender-Specific Differences in Baseline, Peak, and Delta Serum Creatinine: The NACSELD Experience
Abstract
Background
Women have lower serum creatinine values than men for similar renal function.
Aims
We aimed to determine the differential effect of baseline, peak, and delta creatinine between genders on outcomes in infected hospitalized cirrhotic patients.
Methods
North American Consortium for the Study of End-Stage Liver Disease is a 15-center consortium of tertiary care hepatology centers prospectively enrolling infected cirrhotic inpatients. Baseline, peak, and delta creatinine during hospitalization were compared between genders, and their impact on overall survival, transplant-free survival, probability of transplantation, and need for renal replacement therapy (RRT) was analyzed.
Results
In total, 532 patients with cirrhosis (males = 59% median admission MELD = 20) had significantly lower median baseline (1.07 vs. 1.30 mg/dL, p < 0.0001) and peak creatinine (1.47 vs. 1.59 mg/dL, p = 0.024) in women than men during hospitalization for an infection, but both genders had similar delta creatinine levels (0.30 vs. 0.30 mg/dL, p = 0.957). Thirty-day mortality was similar between genders. RRT was not used more often in women (19 vs. 12%, p = 0.050), and women were 1.8 times more likely than men to receive RRT at the same creatinine (p = 0.028). Both peak and delta creatinine significantly predicted 6-month overall and transplant-free survival (p < 0.0001), but the probability of liver transplantation was affected by the interaction between gender and both peak and delta creatinine.
Conclusions
Infected hospitalized cirrhotic women are significantly more likely than men to receive RRT at similar creatinine levels. Gender-specific differences in baseline, peak, and delta creatinine need further investigation to determine whether women need acute kidney injury treatment at lower creatinine thresholds than men.
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Using MutPred derived mtDNA load scores to evaluate mtDNA variation in hypertension and diabetes in a two-population cohort: The SABPA study
Source:Journal of Genetics and Genomics
Author(s): Marianne Venter, Leone Malan, Etresia van Dyk, Joanna L. Elson, Francois H. van der Westhuizen
Mitochondrial DNA (mtDNA) variation has been implicated in many common complex diseases, but inconsistent and contradicting results are common. Here we introduce a novel mutational load hypothesis, which also considers the collective effect of mainly rare variants, utilising the MutPred Program. We apply this new methodology to investigate the possible role of mtDNA in two cardiovascular disease (CVD) phenotypes (hypertension and hyperglycaemia), within a two-population cohort (n = 363; mean age 45 ± 9 yrs.). Very few studies have looked at African mtDNA variation in the context of complex disease, and none using complete sequence data in a well-phenotyped cohort. As such, our study will also extend our knowledge of African mtDNA variation, with complete sequences of Southern Africans being especially under-represented. The cohort showed prevalence rates for hypertension (58.6%) and prediabetes (44.8%). We could not identify a statistically significant role for mtDNA variation in association with hypertension or hyperglycaemia in our cohort. However, we are of the opinion that the method described will find wide application in the field, being especially useful for cohorts from multiple locations or with a variety of mtDNA lineages, where the traditional haplogroup association method has been particularly likely to generate spurious results in the context of association with common complex disease.
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CAMSAP3-dependent microtubule dynamics regulates Golgi assembly in epithelial cells
Source:Journal of Genetics and Genomics
Author(s): Jing Wang, Honglin Xu, Yuqiang Jiang, Mikiko Takahashi, Masatoshi Takeichi, Wenxiang Meng
The Golgi assembly pattern varies among cell types. In fibroblastic cells, the Golgi apparatus concentrates around the centrosome that radiates microtubules; whereas in epithelial cells, whose microtubules are mainly noncentrosomal, the Golgi apparatus accumulates around the nucleus independently of centrosomes. Little is known about the mechanisms behind such cell type-specific Golgi and microtubule organization. Here, we show that the microtubule minus-end binding protein Nezha/CAMSAP3 plays a role in translocation of Golgi vesicles in epithelial cells. This function of CAMSAP3 (calmodulin-regulated spectrin-associated protein 3) is supported by CG-NAP (centrosome and Golgi localized PKN-associated protein) through their binding. Depletion of either one of these proteins similarly induces fragmentation of Golgi membranes. Furthermore, we find that stathmin-dependent microtubule dynamics is graded along the radial axis of cells with highest activity at the perinuclear region, and inhibition of this gradient disrupts perinuclear distribution of the Golgi apparatus. We propose that the assembly of the Golgi apparatus in epithelial cells is induced by a multi-step process, which includes CAMSAP3-dependent Golgi vesicle clustering and graded microtubule dynamics.
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ONGene: A literature-based database for human oncogenes
Source:Journal of Genetics and Genomics
Author(s): Yining Liu, Jingchun Sun, Min Zhao
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Residential Neighborhood Amenities and Physical Activity Among U.S. Children with Special Health Care Needs
Abstract
Objectives Children with special health care needs (SHCN) have or are at elevated risk for chronic physical, developmental, behavioral or emotional conditions and therefore require specialized health care services. This study examines the relationship between residential neighborhood amenities and physical activity among U.S. children with SHCN. Methods A nationally representative sample of 113,767 children aged 6–17 years was taken from National Survey of Children's Health (NSCH) 2007–2008 and 2011–2012. Residential neighborhood amenities were defined by parent-reported presence or absence of sidewalks, parks/playgrounds, and recreation center. Physical activity was measured by parent-reported number of physically active days (0–7), defined as 20 min or longer during the past week. Negative binomial regressions were performed to estimate the associations between residential neighborhood amenities and physical activity among U.S. children with and without SHCN, adjusting for various neighborhood (detracting condition and safety) and individual characteristics and NSCH sampling design. Results Approximately 23% of young children aged 6–11 years and adolescents aged 12–17 years had SHCN. Number of weekly physically active days was both 4.8 among young children with and without SHCN, and 3.7 and 4.1 among adolescents with and without SHCN, respectively. Among young children with SHCN, neighborhood availability of a recreation center was associated with increased weekly physically active days by 0.23; whereas among young children without SHCN, number of weekly physically active days was not associated with the availability of any amenity. Among adolescents with SHCN, neighborhood availability of parks/playgrounds was associated with increased weekly physically active days by 0.33, whereas neighborhood availability of sidewalks was associated with reduced weekly physically active days by 0.21. Conversely, among adolescents without SHCN, neighborhood availability of a recreation center was associated with increased weekly physically active days by 0.22. Conclusions for Practice Vulnerable health status and high dependence on health care may prevent children with SHCN from being physically active. Provision of adequate amenities in residential neighborhoods could be essential in promoting physical activity and preventing obesity among children/adolescents with SHCN.
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Austin ambulance hijacked with crew, patient inside
Crew members updated police with their location and other details as the incident unfolded
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Cardiac output changes with phenylephrine and ephedrine infusions during spinal anesthesia for cesarean section: A randomized, double-blind trial
Hypotension is a common side effect of spinal anesthesia. Phenylephrine and ephedrine are the two most frequently used vasopressors to treat spinal hypotension during cesarean delivery. In this randomized double-blind study, we aimed to evaluate cardiac output (CO) changes with phenylephrine or ephedrine infusions titrated to maintain baseline systolic blood pressure (bSBP) during spinal anesthesia. Women (n = 40) scheduled for elective cesarean delivery received either phenylephrine 100 μg/min or ephedrine 5 mg/min infusions.
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Expression profile of rrbp1 genes during embryonic development and in adult tissues of Xenopus laevis
Source:Gene Expression Patterns
Author(s): Guang-Hui Liu, Cheng-Zhou Mao, Hai-Yan Wu, Deng-Cheng Zhou, Jing-Bo Xia, Soo-Ki Kim, Dong-Qing Cai, Hui Zhao, Xu-Feng Qi
Recent studies suggest that ribosome-binding protein 1 (RRBP1) is involved in multiple diseases such as tumorigenesis and cardiomyopathies. However, its function during embryonic development remains largely unknown. We searched Xenopus laevis database with human RRBP1 protein sequence and identified two cDNA sequences encoding Xenopus orthologs of RRBP1 including rrbp1a (NM_001089623) and rrbp1b (NM_001092468). Both genes were firstly detected at blastula stage 8 with weak signals in animal hemisphere by whole mount in situ hybridization. Evident expression of rrbp1 was mainly detected in cement gland and notochord at neurula and tailbud stages. Heart expression of rrbp1 was detected at stage 36. RT-PCR results indicated that very weak expression of rrbp1a was firstly detected in oocytes, followed by increasing expression until stage 39. Differently, very weak expression of rrbp1b was firstly observed at stage 2, and then maintained at a lower level to stage 17 followed by an intense expression from stages 19–39. Moreover, both expression profiles were also different in adult tissues. This study reports Xenopus rrbp1 expression during early embryonic development and in adult tissues. Our study will facilitate the functional analysis of Rrbp1 family during embryonic development.
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Paramedic and EMT Positions Available - Community EMS
COMMUNITY EMS Paramedic and EMT Positions available at all locations located in Michigan, Ohio and Illinois. Apply at http://ift.tt/2i0VH8n Employer provides: Experience based pay 4 Blue Cross Blue Shield plan options starting as low as $15.00 per month Free Education Bonus Incentive Opportunities Basic EMT Responsibilities: Performs pre-hospital duties in compliance with all state EMS rules and ...
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Idelalisib-induced colitis and skin eruption mimicking graft-versus-host disease
Abstract
Introduction
Idelalisib is a selective inhibitor of the delta isoform of phosphatidylinositol 3-kinase which was approved by the United States Federal Drug Administration in 2014 for the treatment of relapsed chronic lymphocytic leukemia and indolent non-Hodgkin lymphoma. Drug-induced injury of the gastrointestinal tract is a relatively frequent but usually under-recognized disease entity.
Case presentation
We report the case of a 56-year-old male with a history of relapsed follicular lymphoma status post allogenic bone marrow transplant who developed severe diarrhea with a skin eruption mimicking graft-versus-host disease (GVHD) 6 months after starting idelalisib. He underwent a colonoscopy demonstrating a grossly normal-appearing colon and terminal ileum. Biopsies taken during the procedure revealed mild active ileitis, colitis, and proctitis with frequent epithelial apoptosis, and focal intra-epithelial lymphocytosis. Skin biopsies revealed sub-acute spongiotic dermatitis suggestive of either contact dermatitis or an eczematous drug reaction. Symptoms were attributed to idelalisib given their resolution with withdrawal of the drug in conjunction with the skin and colonic biopsies.
Conclusion
High clinical suspicion and awareness of the histological features of idelalisib-associated colitis is important to distinguish it from potential mimickers such as GVHD and infectious colitis.
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Eosinophilic Granuloma of a Child
2016-12-26T12-04-07Z
Source: Journal of Contemporary Medicine
Özgür Demir, Erol Öksüz, Fatih Ersay Deniz.
Eosinophilic granuloma is part of Langerhans cell histiocytosis. It is a rare, benign bone tumor, often involving the head bones. Most patients present between 5 and 15 years of age. Lesions of eosinophilic granuloma may disappear spontaneously. Painful lesions can be treated with radiotherapy, chemotherapy, surgical curettage of the tumor or local infusion of cortisone. A six year old girl presented to our clinic with severe painful swelling on the right parietal region with a gradual increase in size and frequent episodes of headache for 2 months. Radiological findings demonstrated right parietal cranial lytic lesion with intra and extracranial extension. The patient was treated with gross total excision of tumor and cranioplasty without any adjuvant therapy. Histopathology of the tumor showed cellular components of Langerhan cells admixed with chronic cellular infiltrate and eosinophils. Findings were consistent with eosinophillic granuloma. The patient recovered well with no known recurrence till date. There is no definitive treatment option for this disorder. Treatment option may be changed depending on the extent of the disease and the symptoms. We recommend surgical excision in the presence of intracranial extension of painful lesion.
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Determining the Factors Affecting Labor Productivity of Nurses
2016-12-26T10-03-26Z
Source: Journal of Contemporary Medicine
Yurdanur Dikmen, Dilek Kara Yılmaz, Handenur Başaran, Nasibe Yağmur Filiz.
Aim: This study was conducted to determine the factors affecting the labor productivity of nurses. Material and Methods: The study which was planned as descriptive and analytical was carried out with 156 nurses who volunteered to participate in the study in a public hospital in the northwest of Turkey. Data was collected with the Participant Presentation Form and the questionnaire including the factors affecting labor productivity which was developed by Özkoç (2005). In the analysis of data; frequency, percentage, arithmetic average and standard deviation were calculated and in order to examine differences between the independent variables and the scale total scores One Way ANOVA Test, Independent T Test and Pearson Corelation test were used. Results: It was found that the 45.5% of nurses participated in the study were in the 23-53 age group, 79.5% were women, 76.9% married, 41.1% associate degree graduates. 42.3% of nurses durations of professional experience were 0-5 years, 22.4% of nurses were clinical chief, 69.2% were working as shifts. Participants believe that the factors affecting the labor productivity were respectively organizational factors, ergonomic factors and personal factors. When organizational factors was examined; nurses stated that the lack of working personnel in the section, the low wages and unequal wages for the same work, the long working hours and the system which based on personal relations instead of merit were affecting productivity. The factors affecting labor productivity of nurses were not different according to age, gender, education level and marital status (p>0.05), but different according to mode of operation and years of experience (p
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Analysis of prostatic biopsies in a tertiary care hospital in correlation with prostate-specific antigen levels: A clinicopathological study
2016-12-26T06-49-12Z
Source: International Journal of Medical Science and Public Health
Shilpa K Patel, Hrushikesh B Surti.
Background: Benign prostatic hyperplasia (BPH) and adenocarcinoma account for considerable morbidity in aging men. Prostate-specific antigen (PSA) is a useful biomarker in the diagnostics along with digital rectal examination and transrectal ultrasonography. Objective: To analyze various clinicopathological features in benign and malignant prostatic lesions and correlate the histologic findings with pre-operative PSA level for confirmation of diagnosis in cases with a diagnostic dilemma. Material and Methods: The study included 112 prostatic tissue specimens received in the Department of Pathology, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, over the period of 2-year from October 2014 to September 2016. Relevant clinical data and serum PSA value was recorded, and Gleasons microscopic grading was used to grade malignant lesions. Results: Mean age of presentation was 66.5 ± 10.67 years with maximum incidence in the seventh decade of life. BPH (68.79%) was the most common lesion followed by adenocarcinoma (25%). Other lesions encountered were Prostatitis (2 cases), high-grade prostate intraepithelial neoplasia (2 cases), adenosquamous carcinoma (1 case), atypical small acinar proliferation (1 case), and retention cyst (1 case). The most common Gleason score was score 7 (55.17%) followed by score 9 (10.34%) and score 6 (6.9%). Pattern 4 was most common predominant pattern. Serum PSA level was correlated in benign and malignant lesions. Conclusion: With increasing awareness and life expectancy in the current era, histopathological evaluation of prostatic biopsies is mandatory to avoid pitfalls in clinical diagnosis aided by serum PSA assay and other investigations.
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Power spectral analysis of cardiovascular autonomic functional modulation in response to acute psychological stress after induction of acupressure at GV20: An observational study
2016-12-26T06-08-39Z
Source: National Journal of Physiology, Pharmacy and Pharmacology
Nagalakshmi Vijaykumar, Vandana C Kattimani, Shobha C Nallulwar, S L Karne.
Background: Acupressure is a simple, non-invasive, painless method which can be complementary and alternative medicine treatment to reduce stress. Acupressure at GV-20 provides the relief of anxiety and acute stress. Aims and Objectives: Evaluate the effect of GV20 Acupressure on cardiac autonomic functional modulation using heart rate variability (HRV). Materials and Methods: This is a cross-sectional study to investigate the use of an acupressure in acute stress reduction in adults (n = 30). Mental arithmetic stress was administered before and after acupressure. Acupressure was given at GV20 for 5 min, and HRV was measured. The collected data were analyzed for frequency domain using nonparametric method of Fast Fourier Transform, using Ku-bios HRV analysis software. Results: All interventions were associated with the following changes, during stress after acupressure compared to stress before acupressure: Significant increase of total power (P ≤ 0.05), decrease in low frequency (LF), and increase in high frequency (HF) and decrease in LF/HF value. Changes during rest after acupressure and before acupressure are as follows: Decrease in total power, increase in LF, decrease in HF, and decrease in LF/HF but not significant (P ≥ 0.05). Conclusion: Thus, this study indicates that acupressure at GV20 was able to reduce stress in the subjects significantly. This positive finding suggests that acupressure may have a role in reducing acute psychological stress in young adults and help in improving performance.
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Evaluation of fundus findings in preeclampsia [Preeklampside fundus bulgularının değerlendirilmesi]
2016-12-26T04-18-42Z
Source: Medicine Science | International Medical Journal
Erdem Dinc, Mustafa Vatansever, Ozer Dursun, Fatma Merve Bozkurt, Ayse Ayca Sari, Ayca Yıimaz, Ufuk Adiguzel, Ozlem Yildirim, Mehmet Atila Argin.
In this study aimed to evaluate of the fundus examination findings in the patients with preeclampsia. Fundus findings of 45 patients hospitalized in Mersin University Hospital due to preeclampsia and consulted with blurred vision between June 2007 and February 2016 were evaluated retrospectively. The average age of patients was 28.6 ± 6.18 years and mean gestational age was 32.95 ± 4.22. Anterior segment examination was normal in all patients. The fundus findings of thirty five patients were assessed as normal, but pathological findings were detected in ten (%22.2) patients. Unilateral or bilateral serous retinal detachment was observed in six (%60) patients. Retinal hemorrhages and exudates were seen in four (%40) patients. In addition to the fundus findings reversible posterior leucoencephalopathy syndrome was detected in 5 patients. Six patients were delivered vaginally while thirty-nine patients with cesarean section. Serous retinal detachment and fundus findings regressed after delivery in patients. The preeclampsia syndrome is a multisystem disorder and it also can affect the visual pathways. Visual symptoms in preeclampsia include photopsia, visual field defects, blurred vision and, in severe cases, serious blindness. Blurred vision is the most common visual complaint. Hypertensive retinopathy, exudative retinal detachment and cortical blindness can be seen in patients. But in fundus examination pathological findings are not observed in all of the patients admitted with vision loss. Preeclampsia related retinal findings generally resolves after delivery and no additional treatment is required.
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Adaptation Study of the Mindful Eating Questiıonnare (MEQ) into Turkish
2016-12-26T04-17-02Z
Source: Journal of Cognitive-Behavioral Psychotherapy and Research
Gizem KÖSE, Muhittin TAYFUR, İnci BİRİNCİOĞLU, Aslıhan DÖNMEZ.
Adaptation Study of the Mindful Eating Questionnare (MEQ) into Turkish Objective: In this study we aimed to define the mindful eating and discover the reliability and validity analyses of Mindful Eating Questionnare (MEQ) in Turkish sample, which has been developed to evaluate the relationship between eating behavior and mindful eating. Method: 360 volunteer university students included to our study. Participants in the survey asked to fill Turkish form of MEQ and Eating Attitude Test (EAT) completely. The study was completed with 318 participants fully filled the scales. Results: For reliability and validity of Turkish version of MEQ; internal consistency (cronbach alfa 0.733), item-total score analyses, factor analyses, parallel form correlations (As MEQ scores increase and both EAT scores and EAT score group (cutoff:30) increases) and factor correlations [As MEQ scores increase, Disinhibition (r=0.739), Emotional Eating (r=0.700), Control of Eating (r=0.594), Eating Discipline (r=0.449), Mindfullness (r=0.523), Enterferance (r=0.502) increasings are statistically significant (p
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W.Va. EMTs avoid back injury with hydraulic lift machine
A lift, which is installed in the back of the ambulance, works by locking a stretcher into place and sliding the patient safely into the vehicle
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Menopausal hormone therapy and the risk of esophageal and gastric cancer
International Journal of Cancer
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Risk factors associated with complications in cirrhotic patients undergoing endoscopic retrograde cholangio-pancreatography
European Journal of Gastroenterology & Hepatology
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Economic burden of irritable bowel syndrome in China
World Journal of Gastroenterology
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The five-year survival rate after endoscopic submucosal dissection for superficial esophageal squamous cell neoplasia
Digestive and Liver Diseases
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Overexpression of protein phosphatase 1γ (pp1γ) is associated with enhanced cell proliferation and poor prognosis in hepatocellular carcinoma
Digestive Diseases and Sciences
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Long-term follow-up of pepsinogen I/II ratio after eradication of Helicobacter pylori in patients who underwent endoscopic mucosal resection for gastric cancer
Digestive and Liver Diseases
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Hepatitis C viremia reversibly maintains subset of antigen-specific T-bet+ tissue-like memory B-cells
Journal of Viral Hepatitis
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Noninvasive estimation of liver fibrosis in biopsy-proven hepatitis C virus-infected patients: Angiogenic fibrogenic link
European Journal of Gastroenterology & Hepatology
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Adenoma prevalence and distribution among us latino subgroups undergoing screening colonoscopy
Digestive Diseases and Sciences
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A 13-year time trend analysis of 3724 small bowel video capsule endoscopies and a forecast model during the financial crisis in Greece
European Journal of Gastroenterology & Hepatology
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Family PArtners in Lifestyle Support (PALS): Family-based weight loss for African American adults with type 2 diabetes
Obesity
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Radioembolization-induced liver disease: A systematic review
European Journal of Gastroenterology & Hepatology
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FIB-4 and imaging for measuring fibrosis in hepatitis C virus
European Journal of Gastroenterology & Hepatology
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Age- and sex-specific prevalence of diabetes after diseases of the exocrine pancreas: A population-based study
Digestive and Liver Diseases
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Dietary Flavonoid Intake and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort
International Journal of Cancer
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Friends and social contexts as unshared environments: A discordant sibling analysis of obesity- and health-related behaviors in young adolescents
International Journal of Obesity
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Serum bilirubin concentrations and incident coronary heart disease risk among patients with type 2 diabetes: The Dongfeng–Tongji cohort
Acta Diabetologica
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Effects of small intestinal glucose on glycaemia, insulinaemia and incretin hormone release are load-dependent in obese subjects
International Journal of Obesity
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Low yield and high cost of gastric and duodenal biopsies for investigation of symptoms of abdominal pain during routine esophagogastroduodenoscopy
Digestive Diseases and Sciences
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Potential selection effects when estimating associations between the infancy peak or adiposity rebound and later body mass index in children
International Journal of Obesity
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AWARENESS REGARDING SAFE USE OF SHARP-EDGED MEDICAL INSTRUMENTS AMONG NURSES IN TRAINING AND RESEARCH HOSPITAL
2016-12-26T01-07-05Z
Source: Journal of Contemporary Medicine
Selen ÖZAKAR AKCA, Zehra AYDIN.
Objective: The fact that sharp-edged medical instrument injuries are mostly seen among nurses demonstrates the importance of increasing their awareness about this topic. With this present study it is intended to measure the awareness regarding safe use of sharp-edged medical instrument of nurses working in Training and Research Hospitals and to create the basis for the training program planned to be provided on this topic. Method: This descriptive and cross-sectional type study was conducted on nurses (N=365) working in the Training and Research Hospital of Hitit University. No sample selection was made, the sample consisted of nurses (n=259) working during the dates of the study (15.02/15.05.15). Research data has been collected through an Attitude Scale of Health Care Workers to Safe Use of Sharp-Edged Medical Instrument questionnaire and characteristics of participants defining questions. Research data has been evaluated with appropriate statistical methods. p5 years working nurses who participated in the study are higher compared to nurses working ≤ 5 years. This difference was observed as being statistically significant at an advanced level (p
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