2016-07-08T11-31-22Z
Source: Open Veterinary Journal
M.A. Aljameel, M.O. Halima.
Hemangioma is a benign tumor of blood and lymphatic vessels. It is common in skin, mucosa and soft tissues, and its occurrence in lymph nodes is extremely rare. A 10 year-old she-camel was slaughtered at Nyala slaughterhouse, South Darfur State, Sudan. Grossly, the carcass was emaciated. The left ventral superficial cervical lymph node was enlarged, hard on palpation and protruded outside the body. Its cut surface was dark red in color and measured (18 cm) in diameter. Histopathologically, the sections revealed vascular masses were composed of non-encapsulated clusters of small and medium sized with thick and thin-walled, filled with blood, separated by courageous stroma and surrounded by closely packed proliferating capillaries. To the best of our knowledge, this is the first record of the left ventral superficial cervical lymph node hemangioma in a camel in the Sudan.
from Scope via xlomafota13 on Inoreader http://ift.tt/29nVvZR
via IFTTT
Παρασκευή 8 Ιουλίου 2016
Lymph node hemangioma in one-humped camel
Ultrasound and multidetector computed tomography of mandibular salivary gland adenocarcinoma in two dogs
2016-07-08T11-31-22Z
Source: Open Veterinary Journal
D. Lenoci, M. Ricciardi.
Malignant tumors of the salivary glands are rare in dogs, with adenocarcinoma being the most represented. Parotid and mandibular glands are most commonly affected in dogs. Because of local invasivity and high metastatic potential, preoperative imaging evaluation of mandibular region and tumoral staging is essential along with biopsy sampling. The present manuscript describes the ultrasound and computed tomographic imaging findings of mandibular gland adenocarcinoma in two dogs and discusses their clinical utility.
from Scope via xlomafota13 on Inoreader http://ift.tt/29mVKIl
via IFTTT
Cadmium affects the mitochondrial viability and the acid soluble thiols concentration in liver, kidney, heart and gills of Ancistrus brevifilis (Eigenmann, 1920)
2016-07-08T11-31-22Z
Source: Open Veterinary Journal
P. Velasquez-Vottelerd, Y. Anton, R. Salazar-Lugo.
The freshwater fish Ancistrus brevifilis, which is found in Venezuelan rivers, is considered a potential sentinel fish in ecotoxicological studies. The cadmium (Cd) effect on the mitochondrial viability (MV) and acid soluble thiols levels (AST) in A. brevifilis tissues (liver, kidney, heart, and gill) was evaluated. Forty-two fish with similar sizes and weights were randomly selected, of which 7 fish (with their respective replicate) were exposed for 7 and 30 days to a Cd sublethal concentration (0.1 mg.l-1). We determined the MV through a Janus Green B colorimetric assay and we obtained the concentration of AST by Ellmans method. Mitochondrial viability decreased in fish exposed to Cd for 30 days with the liver being the most affected tissue. We also detected a significant decrease in AST levels was in fishes exposed to Cd for 7 days in liver and kidney tissues; these results suggests that AST levels are elevated in some tissues may act as cytoprotective and adaptive alternative mechanism related to the ROS detoxification, maintenance redox status and mitochondrial viability. Organ-specifics variations were observed in both assays. We conclude that the Cd exposure effect on AST levels and MV, vary across fish tissues and is related to the exposure duration, the molecule dynamics in different tissues, the organism and environmental conditions.
from Scope via xlomafota13 on Inoreader http://ift.tt/29nVtkY
via IFTTT
Effectiveness of slow motion video compared to real time video in improving the accuracy and consistency of subjective gait analysis in dogs
2016-07-08T11-31-22Z
Source: Open Veterinary Journal
D.M. Lane, S.A. Hill, J.L. Huntingford, P. Lafuente, R. Wall, K.A. Jones.
Objective measures of canine gait quality via force plates, pressure mats or kinematic analysis are considered superior to subjective gait assessment (SGA). Despite research demonstrating that SGA does not accurately detect subtle lameness, it remains the most commonly performed diagnostic test for detecting lameness in dogs. This is largely because the financial, temporal and spatial requirements for existing objective gait analysis equipment makes this technology impractical for use in general practice. The utility of slow motion video as a potential tool to augment SGA is currently untested. To evaluate a more accessible way to overcome the limitations of SGA, a slow motion video study was undertaken. Three experienced veterinarians reviewed video footage of 30 dogs, 15 with a diagnosis of primary limb lameness based on history and physical examination, and 15 with no indication of limb lameness based on history and physical examination. Four different videos were made for each dog, demonstrating each dog walking and trotting in real time, and then again walking and trotting in 50% slow motion. For each video, the veterinary raters assessed both the degree of lameness, and which limb(s) they felt represented the source of the lameness. Spearmans rho, Cramers V, and t-tests were performed to determine if slow motion video increased either the accuracy or consistency of raters SGA relative to real time video. Raters demonstrated no significant increase in consistency or accuracy in their SGA of slow motion video relative to real time video. Based on these findings, slow motion video does not increase the consistency or accuracy of SGA values. Further research is required to determine if slow motion video will benefit SGA in other ways.
from Scope via xlomafota13 on Inoreader http://ift.tt/29mVI3b
via IFTTT
Independent AMP and NAD signaling regulates C2C12 differentiation and metabolic adaptation
Abstract
The balance of ATP production and consumption is reflected in adenosine monophosphate (AMP) and nicotinamide adenine dinucleotide (NAD) content and has been associated with phenotypic plasticity in striated muscle. Some studies have suggested that AMPK-dependent plasticity may be an indirect consequence of increased NAD synthesis and SIRT1 activity. The primary goal of this study was to assess the interaction of AMP- and NAD-dependent signaling in adaptation of C2C12 myotubes. Changes in myotube developmental and metabolic gene expression were compared following incubation with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and nicotinamide mononucleotide (NMN) to activate AMPK- and NAD-related signaling. AICAR showed no effect on NAD pool or nampt expression but significantly reduced histone H3 acetylation and GLUT1, cytochrome C oxidase subunit 2 (COX2), and MYH3 expression. In contrast, NMN supplementation for 24 h increased NAD pool by 45 % but did not reduce histone H3 acetylation nor promote mitochondrial gene expression. The combination of AMP and NAD signaling did not induce further metabolic adaptation, but NMN ameliorated AICAR-induced myotube reduction. We interpret these results as indication that AMP and NAD contribute to C2C12 differentiation and metabolic adaptation independently.
from Physiology via xlomafota13 on Inoreader http://ift.tt/29VvXEe
via IFTTT
Rapid Response: Paramedic preparation, response to police shot at mass gatherings
As we mourn the deaths of five Dallas police officers paramedics are reminded of the importance in being cautious, calm and conspicuous as caregivers
from EMS via xlomafota13 on Inoreader http://ift.tt/29owpZC
via IFTTT
Aging effect on plasma metabolites and hormones concentrations in riding horses
2016-07-08T11-00-55Z
Source: Open Veterinary Journal
K. Kawasumi, M. Yamamoto, M. Koide, Y. Okada, N. Mori, I. Yamamoto, T. Arai.
Age effects on plasma metabolites, hormone concentrations, and enzyme activities related to energy metabolism were investigated in 20 riding horses. Animals were divided into two groups: young (3-8 years) and aged (11-18 years). They were clinically healthy, and not obese. Plasma adiponectin (ADN) concentrations in aged horses were significantly lower than those in young horses (mean±SE, 6.5±1.3 µg mL-1 vs, 10.9±1.7 µg mL-1, Mann-Whitney U test, respectively; P=0.0233). Plasma non-esterified fatty acid levels and Insulin and malondialdehyde concentrations in aged group tended to increase compared to those in young group although there were not significant differences statistically. In aged group, malate dehydrogenase/lactate dehydrogenase (M/L) ratio, which is considered an energy metabolic indicator, did not change significantly compared to that in young group. Present data suggest that aging may negatively affect nutrition metabolism, but not induce remarkable changes in M/L ratio in riding horses.
from Scope via xlomafota13 on Inoreader http://ift.tt/29ruV1L
via IFTTT
Human Staphylococcus aureus lineages among Zoological Park residents in Greece
2016-07-08T11-00-55Z
Source: Open Veterinary Journal
E. Drougka, A. Foka, D. Posantzis, N. Giormezis, E.D. Anastassiou, E. Petinaki, I. Spiliopoulou.
Staphylococcus aureus is a part of the microbiota flora in many animal species. The clonal spread of S. aureus among animals and personnel in a Zoological Park was investigated. Samples were collected from colonized and infected sites among 32 mammals, 11 birds and eight humans. The genes mecA, mecC, lukF/lukS-PV (encoding Panton-Valentine leukocidin, PVL) and tst (toxic shock syndrome toxin-1) were investigated by PCR. Clones were defined by Multilocus Sequence Typing (MLST), spa type and Pulsed-Field Gel Electrophoresis (PFGE). Seven S. aureus isolates were recovered from four animals and one from an employee. All were mecA, mecC and tstnegative, whereas, one carried the PVL genes and was isolated from an infected Squirrel monkey. Clonal analysis revealed the occurrence of seven STs, eight PFGE and five spa types including ones of human origin. Even though a variety of genotypes were identified among S. aureus strains colonizing zoo park residents, our results indicate that colonization with human lineages has indeed occurred.
from Scope via xlomafota13 on Inoreader http://ift.tt/29uEWPn
via IFTTT
Dual function of the hemagglutinin H5 fused to chicken CD154 in a potential strategy of DIVA against avian influenza disease: preliminary study
2016-07-08T11-00-55Z
Source: Open Veterinary Journal
A.G. Pose, E.S. Rodríguez, A.C. Méndez, J.N. Gómez, A.V. Redondo, E.R. Rodríguez, E.M.G. Ramos, A.Á. Gutiérrez, M.P.R. Moltó, D.G. Roche, Y.S. Ugalde, A.M. López.
In this study we demonstrated that the vaccine candidate against avian influenza virus H5N1 based on the hemagglutinin H5 (HA) fused to the chicken CD154 (HACD) can also be used for differentiating infected from vaccinated animals (DIVA). As the strategy of DIVA requires at least two proteins, we obtained a variant of the nucleoprotein (NP49-375) in E. coli. After its purification by IMAC, the competence of the proteins NP49-375 and HACD as coating antigens in indirect ELISA assays were tested by using the sera of chickens immunized with the proteins HA and HACD and the reference sera from several avian influenza subtypes. Together with these sera, the sera from different species of birds and the sera of chickens infected with other avian viral diseases were analyzed by competition ELISA assays coated with the proteins NP49-375 and HACD. The results showed that the segment CD154 in the chimeric protein HACD did not interfere with the recognition of the molecule HA by its specific antibodies. Also, we observed variable detection levels when the reference sera were analyzed in the ELISA plates coated with the protein NP49-375. Moreover, only the antibodies of the reference serum subtype H5 were detected in the ELISA plates coated with the protein HACD. The competition ELISA assays showed percentages of inhibition of 88-91% for the positives sera and less than 20% for the negative sera. We fixed the cut-off value of these assays at 25%. No antibody detection was observed in the sera from different species of birds or the sera of chickens infected with other avian viral diseases. This study supported the fact that the ELISA assays using the proteins NP49-375 and HACD could be valuable tools for avian influenza surveillance and as a strategy of DIVA for counteracting the highly pathogenic avian influenza virus H5N1 outbreaks.
from Scope via xlomafota13 on Inoreader http://ift.tt/29ruBQA
via IFTTT
Determination of cadmium, lead and mercury residual levels in meat of canned light tuna (Katsuwonus pelamis and Thunnus albacares) and fresh little tunny (Euthynnus alletteratus) in Libya
2016-07-08T11-00-55Z
Source: Open Veterinary Journal
S.K. Abolghait, A.M. Garbaj.
Surveillance for mercury (Hg), lead (Pb) and cadmium (Cd) contamination in tuna products is crucial for consumer food safety. Hg, Pb and Cd contaminants were monitored in a total of 60 specimens of fresh little tunny (Euthynnus alletteratus) and popular brands of skipjack and yellowfin (Katsuwonus pelamis and Thunnus albacares) canned tuna commercially available in Tripoli, Libya. Direct Mercury Analyzer (DMA-80) was implemented for determination of total Hg level and graphite furnace atomic absorption spectrometry (GFAAS) was employed for determination of Cd and Pb concentrations. The results indicated that Hg had the highest concentration level and Cd had the lowest concentration level either in tested canned tuna or fresh little tunny samples. The average concentration of Hg in fresh little tunny samples was 1.185 ± 0.968 mg kg-1 wet weight (ww) and often exceeded the standard permissible limit. In addition, canned yellowfin tuna had the lowest levels of Cd (0.027 ± 0.026 mg kg-1 ww), Pb (0.075 ± 0.071) and Hg (0.163 ± 0.122 mg kg-1 ww). Results of the current surveillance indicated that canned skipjack and yellowfin tuna sold in Tripoli markets show contaminant levels well under the European thresholds adopted for Cd, Pb and Hg. However, consumption of large quantities of Mediterranean little tunny products significantly increases human exposure to the risk of Hg toxicity.
from Scope via xlomafota13 on Inoreader http://ift.tt/29uECQS
via IFTTT
Pyloro-duodenal hernia with formation of enterocutaneous fistula in a buffalo calf following a dog attack
2016-07-08T11-00-55Z
Source: Open Veterinary Journal
G. Kamalakar, V. Devi Prasad, J. Devaratnam, A.Ganeshan.
A body wall hernia entrapping abomasum and concurrent duodenal fistula in a buffalo calf aged about 8 months, secondary to a dog bite was successfully treated by closure of fistulous orifice and ventro lateral herniorrhaphy.
from Scope via xlomafota13 on Inoreader http://ift.tt/29ruJ2J
via IFTTT
Detection of antibodies against Chlamydophila abortus in Costa Rican sheep flocks
2016-07-08T11-00-55Z
Source: Open Veterinary Journal
R. Villagra-Blanco, G. Dolz, D. Montero-Caballero, J.J. Romero-Zúñiga.
A total of 359 sheep samples from 15 flocks were analyzed for the presence of antibodies against Chlamydophila abortus using a commercial Enzyme linked Immunosorbent Assay (ELISA). Antibodies were detected in 19 (5.29%) sheep from 12 (80%) flocks. Seropositive animals were found in all analyzed regions (Central, Chorotega, Atlantic Huetar, North Huetar and Central Pacific) determining prevalence between 0.28% and 4.4%, and intra-flock positivity between 3.7% and 25.0%. The survey revealed two risk factors associated with seropositivity; introducing animals (males and females), embryos, or semen from other farms or from abroad without any sanitary certification, and flocks not having quarantine areas or separated boxes for diseased animals. No clinical signs of disease were observed in positive seroreactors. C. abortus seems to be present in Costa Rica in a very low prevalence in sheep flocks. Further studies, to isolate the bacteria are required. Finally, implementation of control measures to prevent the spread of C. abortus is recommended.
from Scope via xlomafota13 on Inoreader http://ift.tt/29uEDUC
via IFTTT
Intravenous lipid emulsion and dexmedetomidine for treatment of feline permethrin intoxication: a report from 4 cases
2016-07-08T11-00-55Z
Source: Open Veterinary Journal
G. Ceccherini, F. Perondi, I. Lippi, G. Grazia, V. Marchetti.
Four cases of feline permethrin intoxication are described. The cause of intoxication is the application of canine permethrin spot-on product (Advantix®, Bayer) by the owners. Principal clinical guidelines recommends the use of anticonvulsant drugs to treat seizures or neurological symptoms after initial stabilization and dermal decontamination. The use of lipid emulsion had an increasing interest in the last decade for treatment of toxicosis caused by lipophylic drugs as reported in human and in veterinary medical practices. All cats presented in this study, were treated with intravenous lipid emulsion (ILE) at variable dosages, and dexmedetomidine was also administered by intravenous way. No adverse reaction such as thrombophlebitis, overload circulation or others was noticed during and after administration of ILE. Dexmedetomidine was proved to be helpful in tranquillizing the cats. All cats were discharged in good condition faster than other cases treated without their use.
from Scope via xlomafota13 on Inoreader http://ift.tt/29ruFzJ
via IFTTT
Double filtration plasmapheresis in a dog with multiple myeloma and hyperviscosity syndrome
2016-07-08T11-00-55Z
Source: Open Veterinary Journal
I. Lippi, F. Perondi, S.J. Ross, V. Marchetti, G. Lubas, G. Guidi.
A 12 year old, 38 kg, mix-breed, intact male dog presented with a 20 day history of clinical signs consistent with hyperviscosity syndrome secondary to multiple myeloma. The dog received three double filtration plasmapheresis treatments on day 0, 7 and 22 after presentation. A significant (p
from Scope via xlomafota13 on Inoreader http://ift.tt/29uEuAv
via IFTTT
Haemato-biochemical and endocrine profiling of north western Himalayan Gaddi sheep during various physiological/reproductive phases
2016-07-08T11-00-55Z
Source: Open Veterinary Journal
A. Sharma, P. Kumar, M. Singh, N.K. Vasishta.
The study was aimed to provide baseline data regarding haemato-biochemical and endocrine profiling of Gaddi sheep found in north western Himalayan region of Himachal Pradesh, India. Each random sample was collected from 45 Gaddi sheep reared in government sheep breeding farm Tal, Hamirpur, India, during various reproductive phases viz. anestrus, breeding season and post partum period. Haematology revealed significantly higher (P
from Scope via xlomafota13 on Inoreader http://ift.tt/29ruAfB
via IFTTT
Growth performance and certain body measurements of ostrich chicks as affected by dietary protein levels during 2–9 weeks of age
2016-07-08T11-00-55Z
Source: Open Veterinary Journal
Kh.M. Mahrose, A.I. Attia, I.E. Ismail, D.E. Abou-Kassem, M.E. Abd El-Hack.
The present work was conducted to examine the effects of dietary crude protein (CP) levels (18, 21 and 24%) on growth performance (Initial and final body weight, daily body weight gain, feed consumption, feed conversion and protein efficiency ratio) during 2-9 weeks of age and certain body measurements (body height, tibiotarsus length and tibiotarsus girth) at 9 weeks of age. A total of 30 African Black unsexed ostrich chicks were used in the present study in simple randomized design. The results of the present work indicated that initial and final live body weight, body weight gain, feed consumption, feed conversion of ostrich chicks were insignificantly affected by dietary protein level used. Protein efficiency ratio was high in the group of chicks fed diet contained 18% CP. Results obtained indicated that tibiotarsus girth was decreased (P≤0.01) with the increasing dietary protein level, where the highest value of tibiotarsus girth (18.38 cm) was observed in chicks fed 18% dietary protein level. Body height and tibiotarsus length were not significantly different. In conclusion, the results of the present study indicate that ostrich chicks (during 2-9 weeks of age) could grow on diets contain lower levels of CP (18%).
from Scope via xlomafota13 on Inoreader http://ift.tt/29uEHnu
via IFTTT
Early detection of Haemonchus contortus infection in sheep using three different faecal occult blood tests
2016-07-08T10-30-17Z
Source: Open Veterinary Journal
A.V. Rodríguez, V. Goldberg, H. Viotti, G. Ciappesoni.
Haemonchus contortus is a blood-sucking parasite causing the presence of faecal occult blood (FOB). The objective was to study three different FOB tests in order to have a new indicator of H. contortus infection in sheep that could be included in the genetic evaluation system as an alternative selection criterion to faecal worm egg count (FEC). A total of 29 Corriedale lambs were experimentally infected with 10.000 larvae of H. contortus. Stool samples were recorded for FEC and FOB tests (Hexagon, Hematest® and Multistix®), blood for packed cell volume (PCV), haemoglobin, white and red blood cell count (RBC), and FAMACHA© for scoring anaemia. At the end of the experiment lambs were slaughtered to worm burden count. Field infection was achieved in 309 Merino lambs under natural parasite challenge. FEC data were normalized through logarithmic transformation (LnFEC). Pearson correlation was estimated to examine the relationship between all traits. The three tests were able to detect the presence of FOB at day 11. FEC, PCV and RBC decreased to sub-normal values from day 18. FAMACHA© score 3 was considered to be indicative of anaemia. Most of the correlations were of high magnitude, with the exception of Multistix® test that was moderately correlated with haematological parameters, LnFEC and FEC. In field infection, most samples were negative to FOB tests and the correlations were lower than those calculated under experimental infection. In conclusion, FOB tests were able to detect haemonchosis earlier than FEC under high experimental parasite challenge. However, they were not able to detect FOB under natural mixed parasite challenge. FAMACHA© and PCV demonstrated to be good indicators of Haemonchosis, having moderate to high correlations with FEC.
from Scope via xlomafota13 on Inoreader http://ift.tt/29noHjb
via IFTTT
Rapid Response: Paramedic preparation, response to police shot at mass gatherings
What happened: Snipers shot and killed five Dallas police officers. Seven police officers and two bystanders were also shot and injured during a protest of officer-involved shootings in Minnesota and Louisiana earlier this week.
Why it's significant: This is the most deadly law enforcement incident since Sept. 11, 2001. Police officers are public safety brothers and sisters to EMTs and paramedics. They respond with us, call us for help and more than ever they begin medical care — AED use, naloxone administration and tourniquet application — before we arrive.
Top takeaways: This loss of life is heartbreaking and tragic. As we mourn their deaths, worry about the injured officers and try to understand the cowardice of the shooters, we also need to consider our own preparation for responding to incidents at protests, as well as our day-to-day responses to civilians in need of medical care.
1. Mourn and honor the dead
Take a moment, privately or with your colleagues, to pray or think about the loss of life in Dallas. Internalization or the impact of the stress from an event like this is unique to each of us. How you mourn, pay tribute and manage stress from the event is also unique. Manage stress in a way that helps you move forward as a paramedic, partner, parent or spouse.
2. Be conspicuous at all times
In too many response areas, paramedics in blue or black uniforms are indistinguishable from police officers. Be conspicuous in your uniform selection, donning of high-visibility outerwear and parking the ambulance.
As you enter a scene, especially a building, call out regularly, "paramedics coming in" or "paramedics, here to help." Or use some phrase that announces your presence as a caregiver. Repeat throughout the incident, especially if a crowd is gathering, that you are a paramedic and are there to help.
When posting in the ambulance, at protests or as part of normal operations, consider locations that offer cover or concealment. Or pick high-visibility locations.
Regardless of the location, at least one member of the crew has to have their head up, not buried in a smartphone, and their eyes open, scanning their surroundings. Agencies with a predictable posting routine — schedule and locations — need to add variability and randomness to the posting pattern.
3. Be cautious and calm
More and more agencies are making the decision to equip paramedics with body armor. This is a reasonable precaution for every response and especially important when responding to or staging at mass gatherings that are or may become violent.
If your agency is considering an EMS body armor purchase, be thoughtful to the color and lettering. Red, green or light blue with bold 'EMS' or 'PARAMEDIC' distinguishes personnel as caregivers and not combatants.
If you are staging at a protest, be aware that as the crowd moves, grows or disperses the ingress and egress routes for ambulances change. Be situationally aware of the options to drive right, left, forward or backwards.
Don't match the emotional intensity of the crowd or the police officers. Yelling, "Calm the f…' down," never works and your surging adrenaline narrows your field of vision and perception of risks in a volatile environment.
4. Constantly remind the public that medics are the helpers
Every day is an opportunity to remind the public through face-to-face interactions, social network postings and media appearances that paramedics are the helpers. When anyone, civilian or police officer, is sick or injured we will respond, assess and treat with all of the skills and resources we have.
Learn more about mass gatherings and EMS safety. And share your top takeaways in the comments for EMS response to violence at protests and mass gatherings.
from EMS via xlomafota13 on Inoreader http://ift.tt/29GKVSd
via IFTTT
Inside EMS Special Podcast: How to prepare for and respond to violence at protests
Download this podcast on iTunes, SoundCloud or via RSS feed
In this special episode of the Inside EMS podcast host Chris Cebollero and EMS1 Editor-in-Chief Greg Friese discuss the shooting deaths of five Dallas police officers during a protest Thursday night. Cebollero describes the lessons, success and mistakes he made as the Christian Hospital EMS chief during the violence and riots in Ferguson, Missouri. Cebollero makes important points about force protection, staging of ambulances and personnel, awareness of ingress and egress routes, stress management, utilizing unified command, and regularly briefing personnel.
Listen to the show and share your comments and resources for EMS operations at mass gatherings that turn violent in the comments.
Additional reading and resources
- What EMS crews experienced on Ferguson Day 1
- Behind the scenes of Ferguson's mayhem
- EMS managing stress and fatigue at Ferguson
- EMS challenges and lessons learned from the Ferguson riots
- During Ferguson crisis vision statement was foundation for successful leadership
- Medic describes anger, heartbreak of Ferguson riots
- EMS coverage for mass gatherings and public events
from EMS via xlomafota13 on Inoreader http://ift.tt/29sBt2o
via IFTTT
A rare case of urinary bladder endometriosis along with ureteric and ureterovesical junction involvement following cesarean section
2016-07-08T09-25-03Z
Source: Case Study and Case Report
Kalpana Singh, Geetam Bharti, Vijoy Kumar, Anshul Garg, Abhay Kumar, Pranay Kumar.
Urinary tract endometriosis is a rare condition involving 1% of woman having pelvic endometriosis with predominantly urinary bladder involvement (84%). We report a case of urinary bladder endometriosis presenting as a polypoidal tumor in the left posterolateral wall of the urinary bladder base and left ureteo-vesical junction and left lower ureter. A 25 year old woman with history of two LSCS, presented with chief complaints of severe dysuria, burning micturition, suprapubic pain and left sided flank pain. In Ultrasound and CT Urography there was severe hydronephrosis of left kidney with marked cortical thinning and approx 10×17 mm soft tissue density mass near left uretrovesical junction causing obstruction to left uretric opening leading to left uretric dilatation. Cystoscopy showed 0.3x0.5 cm polypoidal, reddish blue coloured lesion around area of left uretric opening. Transurethral resection of polypoidal lesion was done and HPE showed features of papillary cystitis. Follow up shows recurrence of the mass at same place with mildly asymmetric mural thickening of the posterolateral wall of bladder base and VUJ with grossly hydronephrotic left kidney showing parenchymal thinning and delayed and reduced excretion of contrast in collecting system in CT urography. Exploration followed by complete excision of the mass from the left lower ureter and urinary bladder with left ureteroneocystostomy was done.Histopathological examination of excised mass was suggestive of endometriosis. Subsequently she was put on hormonal therapy on which she is doing well. Clinicians should suspect urinary tract endometriosis in woman in reproductive age group, presenting with urinary symptoms, especially following Cesarean section.Thorough history, physical examination, and imaging can potentially help in the diagnosis. Main goals of the treatment should be preservation of renal function, relief of obstruction and prevention of recurrence.
from Scope via xlomafota13 on Inoreader http://ift.tt/29wmu82
via IFTTT
Inside EMS Special Podcast: How to prepare for and respond to violence at protests
Chris Cebollero and Greg Friese discuss the tragic deaths of five Dallas police officers and the immediate steps EMS leaders need to take to prepare their crews for violence at mass gatherings
from EMS via xlomafota13 on Inoreader http://ift.tt/29wjt7Q
via IFTTT
Choices of Incidental Findings of Individuals Undergoing Genome Wide Sequencing, a Single Center's Experience
ABSTRACT
Genome wide sequencing is an emerging clinical tool that may provide information on genetic variants that are not directly related to the patient's primary disorder. These incidental findings (IFs) may include information about conditions that can be treated but may also indicate conditions for which treatments are not currently available. Data is currently limited regarding what IFs an individual would want disclosed. This study reports on 305 individual choices for return of IFs that were completed at the Medical College of Wisconsin's clinical sequencing laboratory. Individuals were given access to 5 categories of IFs to select from: no incidental findings, untreatable childhood disorders, treatable adulthood disorders, untreatable adulthood disorders, and carrier of a disorder. Retrospective chart review was conducted and individual choices were recorded and analyzed. 76.1% of individuals selected every IF to be reported, 14.4% wanted a subset of the options, and 9.5% did not want any IFs reported. This study contributes to the limited data that demonstrates what an individual would actually choose when undergoing genetic sequencing. Furthermore, this data supports the opinion that individuals want and utilize the ability to choose the findings reported.
from Genetics via xlomafota13 on Inoreader http://ift.tt/29w4QkR
via IFTTT
Synuclein expression in the lizard Anolis carolinensis
Abstract
The synuclein (syn) family comprises three proteins: α-, β- and γ-syns. In humans, they are involved in neurodegenerative diseases such as Parkinson's disease and in tumors. Members of the syn family were sequenced in representative species of all vertebrates and the comparative analysis of amino acid sequences suggests that syns are evolutionarily conserved, but information about their expression in vertebrate lineages is still scarce and completely lacking in reptiles. In this study, the expression of genes coding for α-, β- and γ-syns was analyzed in the green lizard Anolis carolinensis by semiquantitative RT-PCR and Western blot. Results demonstrate good expression levels of the three syns in the lizard nervous system, similarly to human syns. This, together with the high identity between lizard and human syns, suggests that these proteins fulfill evolutionarily conserved functions. However, differences between lizard and humans in the expression of syn variants (two different variants of γ-syn were detected in A. carolinensis) and differences in some amino acids in key positions for the regulation of protein conformation and affinity for lipid and metal ions also suggest that these proteins may have acquired different functional specializations in the two lineages.
from Physiology via xlomafota13 on Inoreader http://ift.tt/29DIOft
via IFTTT
Paramedic - A&E Emergency Services, LLC
Go to our website and click on the employement tab at the bottom on page. The application will have a full discription of the job. We are a private ambulance service. We transport everything from doctor's appointments, wound care appointments, dialysis appointments to hospital transfers and critical care transfers. We do run a fair number of emergency calls including back up 911 calls for the current ...
from EMS via xlomafota13 on Inoreader http://ift.tt/29FIXBE
via IFTTT
AEMT - A&E Emergency Services, LLC
Go to our website and click on the employement tab at the bottom on page. The application will have a full discription of the job. We are a private ambulance service. We transport everything from doctor's appointments, wound care appointments, dialysis appointments to hospital transfers and critical care transfers. We do run a fair number of emergency calls including back up 911 calls for the current ...
from EMS via xlomafota13 on Inoreader http://ift.tt/29vtF0s
via IFTTT
Effect of Euphorbia humifusa Willd extract on the amelioration of innate immune responses
Abstract
Euphorbia humifusa Willd is an annual plant widely used as a vegetable and traditional medicinal herb. E. humifusa Willd displays a variety of pharmacological actions; however, the effect of E. humifusa Willd on the innate immune response has not been well characterized. The aim of this study is to investigate the effect of an E. humifusa Willd methanolic extract (EuH) on the activation of innate immune cells. Here, we found that the EuH increased the expression of the innate cytokines, TNFα and IL-1β, in THP-1 monocytes and THP-1-derived macrophages. In addition, the EuH enhanced the phagocytosis of THP-1-derived macrophages. These findings suggest that E. humifusa Willd may be helpful for preventing bacterial infection and could be developed as a dietary supplement for ameliorating innate immune response.
from Genetics via xlomafota13 on Inoreader http://ift.tt/29BiV2u
via IFTTT
Ultrasound indications for chronic pain management: an update on the most recent evidence.
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/29zt5PT
via IFTTT
Adjunct analgesic drugs to local anaesthetics for neuroaxial blocks in children.
from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/29myuWE
via IFTTT
Cerebellar physiology – links between microcircuitry properties and sensorimotor functions
The cerebellar neuronal circuitry is here summarized as a gigantic associative memory, consisting of multiple functional subunits working in parallel, by which useful contingencies between diverse types of information can be stored. The sources of information are the multiple mossy fiber systems that inform the cerebellum about original motor commands/motor plans and sensorimotor information at different levels of abstraction. The output of each functional subunit of the cerebellum is refining the ongoing movement command by linking learnt appropriate sensorimotor functions for the particular context or state. Because of its size, the memory element can house the appropriate associations, translatable to synaptic weights, relevant for all contexts or states that the individual can be expected to experience during a lifetime. It follows that a key component necessary to further improve our understanding of cerebellar function is a precise knowledge of the types and formats of information that reaches the cerebellum via the vast variety of mossy fiber pathways, a subject area that has long been neglected. In parallel, a large part of the cerebellar circuitry is proposed to be devoted to regulating the activity balance in the circuitry. The set points of the balances are internal to the cerebellar neuronal circuitry but influence the excitability of the extracerebellar motor structures so that the drive on individual muscles, for example, is not exaggerated or fall below operative excitation level. The review explores the consistency of this novel interpretational framework with multiple diverse observations at the synaptic and microcircuitry level within the cerebellum.
This article is protected by copyright. All rights reserved
from Physiology via xlomafota13 on Inoreader http://ift.tt/29m0myA
via IFTTT
Can I trust in what I see? EEG evidence for a cognitive evaluation of perceptual constructs
Abstract
Environmental information available to our senses is incomplete and to varying degrees ambiguous. It has to be disambiguated in order to construct stable and reliable percepts. Ambiguous figures are artificial examples where perception is maximally unstable and alternates between possible interpretations. Tiny low-level changes can disambiguate an ambiguous figure and thus stabilize percepts. The present study compares ERPs evoked by ambiguous stimuli and disambiguated stimulus variants across three visual categories: geometry (Necker cube), motion (stroboscopic alternative motion stimulus, SAM) and semantics (Boring's old/young woman). We found that (a) disambiguated stimulus variants cause stable percepts and evoke two huge positive ERP excursions (Cohen's effect sizes 1–2), (b) the amplitudes of these ERP effects are inversely related to the degree of stimulus ambiguity, and (c) this pattern of results is consistent across all three tested visual categories. This generality across visual categories points to mechanisms at a very abstract (cognitive) level of processing. We discuss our results in the context of a high-level Bayesian inference unit that evaluates the reliability of perceptual processing results, given a priori incomplete, ambiguous sensory information. The ERP components may reflect the outcome of this reliability estimation.
from Physiology via xlomafota13 on Inoreader http://ift.tt/29Fxm5B
via IFTTT
Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: An update
World Journal of Gastroenterology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29so2P8
via IFTTT
Long-term lamivudine therapy in chronic hepatitis B
Alimentary Pharmacology and Therapeutics
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29raAPl
via IFTTT
Correlations of nonalcoholic fatty liver disease and serum uric acid with subclinical atherosclerosis in obese Chinese adults
Journal of Diabetes
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29sooF6
via IFTTT
Prediagnostic plasma 25-hydroxyvitamin D and pancreatic cancer survival
Journal of Clinical Oncology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29raGqc
via IFTTT
A review of percutaneous transhepatic biliary drainage at a tertiary referral centre
Clinical Radiology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29soddh
via IFTTT
Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals Follow-up Study
International Journal of Cancer
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29raGGI
via IFTTT
Risk factors for metachronous colorectal cancer or polyp: A systematic review and meta-analysis
Journal of Gastroenterology and Hepatology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29soo84
via IFTTT
Adolescents with irritable bowel syndrome report increased eating-associated symptoms, changes in dietary composition, and altered eating behaviors: A pilot comparison study to healthy adolescents
Neurogastroenterology & Motility
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29ramro
via IFTTT
Healthcare burden of obstructive sleep apnea and obesity among asthma hospitalizations: Results from the U.S.-based Nationwide Inpatient Sample
Respiratory Medicine
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29somwZ
via IFTTT
A prospective study of angiogenic markers and postmenopausal breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial
Cancer Causes and Control
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29razLm
via IFTTT
Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity
Nutrition, Metabolism & Cardiovascular Diseases
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29sotJ2
via IFTTT
Entecavir plasma concentrations are inversely related to HBV-DNA decrease in a cohort of treatment-naïve patients with chronic hepatitis B
International Journal of Antimicrobial Agents
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29ral6L
via IFTTT
Safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn's disease – A phase 1 trial with three doses
Alimentary Pharmacology and Therapeutics
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29sofSn
via IFTTT
Randomized, double-blind, placebo-controlled trial to evaluate the effect of Helicobacter pylori eradication on glucose homeostasis in type 2 diabetic patients
Nutrition, Metabolism & Cardiovascular Diseases
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29rao2O
via IFTTT
Imaging, endoscopy, and pathologic findings of primary gastritis cystica polyposa: Description of a rare entity in a small case series
Abdominal Imaging
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29FvwkQ
via IFTTT
Liver fibrosis linked to cognitive performance in HIV and hepatitis C
Journal of Acquired Immune Deficiency Syndromes
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29sogWc
via IFTTT
Effect of obesity on the effectiveness of cardiac resynchronization to reduce the risk of first and recurrent ventricular tachyarrhythmia events
Cardiovascular Diabetology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29raxD9
via IFTTT
Predictive factors of the pharmacological action of tolvaptan in patients with liver cirrhosis: A post hoc analysis
Journal of Gastroenterology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29sokVS
via IFTTT
The epidemiology, prevalence and hospital outcomes of infants with gastroschisis
Journal of Perinatology
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29rapDy
via IFTTT
Prognostic value of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with Barcelona Clinic Liver Cancer stages 0 and A hepatocellular carcinomas: A multicenter retrospective cohort study
European Journal of Nuclear Medicine & Molecular Imaging
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29BaDYx
via IFTTT