Τρίτη 1 Μαΐου 2018
Precise isometric hand grip learning of hemiparetic stroke patients
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Comments on: ‘Effects of walking trainings on walking function among stroke survivors a systematic review’
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The role of robotic gait training coupled with virtual reality in boosting the rehabilitative outcomes in patients with multiple sclerosis
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Measuring work functioning in individuals with musculoskeletal disorders with reference to the International Classification of Functioning, Disability, and Health: a systematic literature review
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Smartphone technology: a reliable and valid measure of knee movement in knee replacement
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Are graft-versus-host-disease patients missing out on the vital occupational therapy services? a systematic review
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A pilot mixed-methods evaluation of MS INFoRm: a self-directed fatigue management resource for individuals with multiple sclerosis
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A ‘musculoskeletal look’ to sarcopenia: Where do/should the physical and rehabilitation medicine physicians (physiatrists) stand?
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Executive functioning and daily living of individuals with chronic stroke: measurement and implications
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Use of pain medication before and after inpatient musculoskeletal rehabilitation: longitudinal analysis of a nationwide cohort
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Reliability of translation of the RAND 36-item health survey in a post-rehabilitation population
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Comparison between three types of prosthetic feet: a randomized double-blind single-subject multiple-rater trial
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Effectiveness of a single session of dual-transcranial direct current stimulation in combination with upper limb robotic-assisted rehabilitation in chronic stroke patients: a randomized, double-blind, cross-over study
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The importance of specific rehabilitation for an obese patient with idiopathic intracranial hypertension: a case report
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Effect of inpatient rehabilitation on activities of daily living in pediatric cancer patients in Japan
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Comment on the Letter to the Editor by Mohammad Alwardat and Mohammad Etoom on ‘Effects of walking trainings on walking function among stroke survivors: a systematic review’
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Transpapillary endopancreatic surgery: decompression of duct system and comparison of greenlight laser with monopolar electrosurgical device in ex vivo and in vivo animal models
Abstract
Background
Endopancreatic surgery (EPS) is an experimental minimally invasive technique for resection of pancreatic tissue from inside the pancreatic duct, accessed via the duodenum and papilla. It is proposed as an alternative to duodenum-preserving pancreatic head resection in benign diseases such as chronic pancreatitis (CP). This study evaluated the use of EPS for resection of pancreatic duct stenoses. Moreover, greenlight laser (GLL) and monopolar electrosurgical device (MES) were compared as resection tools for EPS.
Methods
The suitability of EPS for resection of stenoses was evaluated in ex vivo bovine pancreas (n = 8). Artificially created stenoses in the pancreatic head were accessed via the duodenal papilla and resected from inside the organ with MES through a rigid endoscope. Furthermore, standardized pancreatic resections were performed in an in vivo porcine model using either GLL (n = 18) or MES (n = 18) to compare blood loss, operating time, and complications. Thermal damage to the surrounding tissue was assessed using a standardized histological classification.
Results
Stenosis resection by EPS was feasible in 8/8 bovine pancreases, with a procedure time of 17 (12–24) min. No perforation of the organ occurred. Resection by GLL was associated with reduced blood loss [median 1.7 (interquartile range 0.6–2.6) ml vs. 5.1 (3.8–13.2) ml; p < 0.01] and shorter operating time [109 (81–127) s vs. 390 (337–555) s; p < 0.01] compared with MES. The zone of thermal tissue damage was more extensive when using GLL than with MES [4.12 (3.48–4.89) mm vs. 1.33 (1.09–1.48) mm; p < 0.01].
Conclusion
Transduodenal-transpapillary EPS can be used to resect stenoses and decompress the pancreatic duct system. Both GLL and MES are feasible resection methods for EPS. However, GLL showed better hemostatic characteristics than MES in an in vivo porcine model. Safety measures such as temperature control and image-guided navigation should be employed to monitor the resection and tissue heating.
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All in: expansion of the acquisition of data for outcomes and procedure transfer (ADOPT) program to an entire SAGES annual meeting hands-on hernia course
Abstract
Background
Continuing professional development (CPD) for the surgeon has been challenging because of a lack of standardized approaches of hands-on courses, resulting in poor post-course outcomes. To remedy this situation, SAGES has introduced the ADOPT program, implementing a standardized, long-term mentoring program as part of its hernia hands-on course. Previous work evaluating the pilot program showed increased adoption of learned procedures as well as increased confidence of the mentored surgeons. This manuscript describes the impact of such a program when it is instituted across an entire hands-on course.
Methods
Following collection of pre-course benchmark data, all participants in the 2016 SAGES hands-on hernia course underwent structured, learner-focused instruction during the cadaveric lab. All faculty had completed a standardized teaching course in the Lapco TT format. Subsequently, course participants were enrolled in a year-long program involving longitudinal mentorship, webinars, conference calls, and coaching. Information about participant demographics, training, experience, self-reported case volumes, and confidence levels related to procedures were collected via survey 3 months prior to 9 months after the course.
Results
Twenty surgeons participated in the SAGES ADOPT 2016 hands-on hernia program. Of these, seventeen completed pre-course questionnaires (85%), ten completed the 3-month questionnaire (50%), and four completed the 9-month questionnaire (20%). Nine of ten respondents of the 3-month survey (90%) reported changes in their practice. In the 9-month survey, significant increases in the annualized procedural volumes were reported for open primary ventral hernia repair, open components separation, and mesh insertion for ventral hernia repair (p < 0.001).
Conclusions
The expansion of the ADOPT program to an entire hands-on hernia course is both feasible and beneficial, with evidence of Kirkpatrick Levels 1–4a training effectiveness. This expanded success suggests that it is a useful blueprint for the CPD of surgeons wishing to learn new techniques and procedures for their patients.
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Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers [Genetics]
ATRX (alpha thalassemia/mental retardation X-linked) complexes with DAXX to deposit histone variant H3.3 into repetitive heterochromatin. Recent genome sequencing studies in cancers have revealed mutations in ATRX and their association with ALT (alternative lengthening of telomeres) activation. Here we report depletion of ATRX in mouse ES cells leads to selective...
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Synthetically engineered Medea gene drive system in the worldwide crop pest Drosophila suzukii [Genetics]
Synthetic gene drive systems possess enormous potential to replace, alter, or suppress wild populations of significant disease vectors and crop pests; however, their utility in diverse populations remains to be demonstrated. Here, we report the creation of a synthetic Medea gene drive system in a major worldwide crop pest, Drosophila...
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Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM [Genetics]
CRISPR/Cas9-based transcriptional activation (CRISPRa) has recently emerged as a powerful and scalable technique for systematic overexpression genetic analysis in Drosophila melanogaster. We present flySAM, a potent tool for in vivo CRISPRa, which offers major improvements over existing strategies in terms of effectiveness, scalability, and ease of use. flySAM outperforms existing...
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O6-methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function [Genetics]
Altered protein function due to mutagenesis plays an important role in disease development. This is perhaps most evident in tumorigenesis and the associated loss or gain of function of tumor-suppressor genes and oncogenes. The extent to which lesion-induced transcriptional mutagenesis (TM) influences protein function and its contribution to the development...
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Mechanism of cancer: Oncohistones in action
Source:Journal of Genetics and Genomics
Author(s): Lei Qiu, Xiaoyan Hu, Qian Jing, Xinyi Zeng, Kui-Ming Chan, Junhong Han
Oncohistones are histones with high-frequency point mutations that are associated with tumorigenesis. Although each histone variant is encoded by multiple genes, a single mutation in one allele of one gene seems to have a dominant effect over global histone H3 methylation level at the relevant amino acid residue. These oncohistones are highly tumor type specific. For example, H3K27M and H3G34V/R mutations occur only in pediatric brain cancers, whereas H3K36M and H3G34W/L have only been found in pediatric bone tumors. H1 mutations also seem to be exclusively linked to lymphomas. In this review, we discuss the occurrence, frequency and potential functional mechanisms of each oncohistone in tumorigenesis of its relevant cancer. We believe further investigation into the mechanism regarding their tumor type specificity and cancer-related functions will shed new light on their application in cancer diagnosis and targeted therapy development.
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Boy saves brother with skills learned at first responder camp
Zimori Hall had just completed a one-week "911 Jr. First Responder Camp" where he learned the basics of first aid, CPR training and the Heimlich Maneuver
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Researchers developing drone air ambulance
Caltech researchers have designed what they call a "personal rescue system" that was created to quickly get a patient to a hospital or doctor
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Quiz: How well do you know 'Stop the Bleed'?
In the event of an MCI, there may be a number of victims who require immediate treatment to stop life-threatening hemorrhaging
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Neutrophil to lymphocyte ratio associates independently with mortality in hospitalized patients with cirrhosis
Clinical Gastroenterology and Hepatology
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Clarifying the role of C-reactive protein as a bacterial infection predictor in decompensated cirrhosis
European Journal of Gastroenterology & Hepatology
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Previous use of anti-thrombotic agents reduces mortality and length of hospital stay in patients with high-risk upper gastrointestinal bleeding
Clinical Gastroenterology and Hepatology
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Randomised clinical trial: A leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease
Alimentary Pharmacology and Therapeutics
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Acetyl-CoA carboxylase inhibitor GS-0976 for 12 weeks reduces hepatic de novo lipogenesis and steatosis in patients with nonalcoholic steatohepatitis
Clinical Gastroenterology and Hepatology
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Elevated circulating miR-182 acts as a diagnostic biomarker for early colorectal cancer
Cancer Management and Research
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Pre-operative evaluation of the adult patient undergoing elective noncardiac surgery: updated guideline from the European Society of AnaesthesiologyDirection and not directives
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Pre-operative evaluation of adults undergoing elective noncardiac surgery: Updated guideline from the European Society of Anaesthesiology
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Anaesthesia in High-Risk Patients
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