Τρίτη 29 Νοεμβρίου 2016

Influence of menstrual phase and arid vs. humid heat stress on autonomic and behavioural thermoregulation during exercise in trained but unacclimated women

Abstract

We studied thermoregulatory responses of ten well-trained (VO2max, 57 (7) mL min−1 kg−1) eumenorrheic women exercising in dry and humid heat, across their menstrual cycle. They completed four trials, each of resting and cycling at fixed intensities (125 and 150 W), to assess autonomic regulation, then self-paced intensity (30-min work trial), to assess behavioural regulation. Trials were in early-follicular (EF) and mid-luteal (ML) phases in dry (DRY) and humid (HUM) heat matched for wet bulb globe temperature (WBGT, 27°C). During rest and fixed-intensity exercise, rectal temperature was ∼0.2°C higher in ML than EF (p < 0.01) independent of environment (p = 0.66). Mean skin temperature did not differ between menstrual phases (p ≥ 0.13) but was higher in DRY than HUM (p < 0.01). Local sweat rate and/or forearm blood flow differed as a function of menstrual phase and environment (interaction: p ≤ 0.01). Exercise performance did not differ between phases (EF: 257 (37), ML: 255 (43) kJ, p = 0.62), but was 7 (9)% higher in DRY than HUM (263 (39), 248 (40) kJ; p < 0.01) in conjunction with equivalent autonomic regulation and thermal strain but higher evaporative cooling (16 (6) W m−2; p < 0.01). In well-trained women exercising in the heat: i) menstrual phase did not affect performance, ii) humidity impaired performance due to reduced evaporative cooling despite matched WBGT, and iii) behavioural responses nullified thermodynamic and autonomic differences associated with menstrual phase and dry vs. humid heat.

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Unfolded Protein Response Promotes Doxorubicin-Induced Nonsmall-Cell Lung Cancer Cells Apoptosis via the mTOR Pathway Inhibition

Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0.


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Special issue of the Journal of Environmental Radioactivity: Geogenic radiation and its potential use for developing the geogenic radon map – Foreword

Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): Tore Tollefsen, Giorgia Cinelli, Marc De Cort




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Estimation and mapping of uranium content of geological units in France

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): G. Ielsch, M. Cuney, F. Buscail, F. Rossi, A. Leon, M.E. Cushing
In France, natural radiation accounts for most of the population exposure to ionizing radiation. The Institute for Radiological Protection and Nuclear Safety (IRSN) carries out studies to evaluate the variability of natural radioactivity over the French territory. In this framework, the present study consisted in the evaluation of uranium concentrations in bedrocks. The objective was to provide estimate of uranium content of each geological unit defined in the geological map of France (1:1,000,000). The methodology was based on the interpretation of existing geochemical data (results of whole rock sample analysis) and the knowledge of petrology and lithology of the geological units, which allowed obtaining a first estimate of the uranium content of rocks. Then, this first estimate was improved thanks to some additional information. For example, some particular or regional sedimentary rocks which could present uranium contents higher than those generally observed for these lithologies, were identified. Moreover, databases on mining provided information on the location of uranium and coal/lignite mines and thus indicated the location of particular uranium-rich rocks. The geological units, defined from their boundaries extracted from the geological map of France (1:1,000,000), were finally classified into 5 categories based on their mean uranium content. The map obtained provided useful data for establishing the geogenic radon map of France, but also for mapping countrywide exposure to terrestrial radiation and for the evaluation of background levels of natural radioactivity used for impact assessment of anthropogenic activities.



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Radon in the soil air of Estonia

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): Valter Petersell, Krista Täht-Kok, Mark Karimov, Heli Milvek, Siim Nirgi, Margus Raha, Krista Saarik
Several investigations in Estonia during 1996¬-1999 have shown that permissible level (200 Bq/m3) of radon (222Rn) in indoor air is exceeded in 33% of the inspected dwellings. This makes Estonia one of the five countries with highest radon risk in Europe (Fig 1). Due to correlation between the soil radon risk level and radon concentration in houses, small scale radon risk mapping of soil air was carried out (one study point per 70–100 km2). It turned out that one-third of Estonian mainland has high radon risk potential, where radon concentration in soil air exceeds safe limit of 50 kBq/m3.In order to estimate radon content in soil air, two different methods developed in Sweden were used simultaneously. Besides measuring radon content from soil air at the depth of 80 cm with an emanometer (RnM), maximum potential content of radon in soil (RnG) was estimated based on the rate of eU (226Ra) concentration in soil, which was acquired by using gamma-ray spectrometer.Mapping and following studies revealed that simultaneously measured RnG and RnM in study points may often differ. To inspect the cause, several monitoring points were set up in places with different geological conditions. It appeared that unlike the RnG content, which remains close to average level in repeated measurements, the RnM content may differ more than three times periodically. After continuous observations it turned out that concentration of directly measured radon depended on various factors being mostly controlled by mineral composition of soil, properties of topsoil as well as different factors influencing aeration of soil.The results of Rn monitoring show that reliable level of radon risk in Estonian soils can only be acquired by using calculated Rn-concentration in soil air based on eU content and directly measured radon content of soil air in combination with interpreting specific geological and geochemical situations in the study points.



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Mapping natural radioactivity of soils in the eastern Canary Islands

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): M.A. Arnedo, J.G. Rubiano, H. Alonso, A. Tejera, A. González, J. González, J.M. Gil, R. Rodríguez, P. Martel, J.P. Bolivar
The Canary Islands archipielago (Spain) comprises seven main volcanic islands and several islets that form a chain extending for around 500 km across the eastern Atlantic, between latitudes 27°N and 30°N, with its eastern edge only 100 km from the NW African coast. The administrative province of Las Palmas comprises the three eastern Canary Islands (Lanzarote, Fuerteventura and Gran Canaria). An extensive study of terrestrial gamma dose rates in surface soils has been carried out to cover the entire territory of the province (4093 km2). The average outdoor gamma dose rate in air at 1 m above ground is 73 nGyh−1 at Gran Canaria, 32 nGyh−1 at Fuerteventura, and 25 nGyh−1 at Lanzarote. To complete the radiological characterization of this volcanic area, 350 soil samples at 0–5 cm depth were collected to cover all the geologic typologies of the islands. These samples were measured using high resolution gamma spectrometry to determine the activity concentrations of 226Ra, 232Th and 40K. The average values obtained were 25.2 Bq/kg, 28.9 Bq/kg, and 384.4 Bq/kg, respectively. Maps of terrestrial gamma activity, effective dose, and activity concentrations of 226Ra, 232Th and 40K for the region have been developed through the use of geostatistical interpolation techniques. These maps are in accord with the geology of the islands.



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Editorial board

Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2





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Assessment of lithogenic radioactivity in the Euganean Hills magmatic district (NE Italy)

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): Laura Tositti, Giorgia Cinelli, Erika Brattich, Antonio Galgaro, Domiziano Mostacci, Claudio Mazzoli, Matteo Massironi, Raffaele Sassi
The Euganean Hills of North East Italy have long been recognised as an area characterized by a higher than average natural radiation background. This is due to two main reasons: a) primary lithogenic radiation due to rhyolitic and trachytic outcrops, which are "acidic alkaline" magmatic rocks potentially enriched in uranium and thorium; b) secondary sources related to a geothermal field – widely exploited for spa tourism in the area since the Roman age – producing surface release of radon-enriched fluids.Though radioactivity levels in the Euganean district have been often investigated in the past – including recent works aimed at assessing the radiation doses from radon and/or total gamma radiation – no effort has been put so far into producing a thorough assessment linking radiation protection data to geological-structural features (lithology, faults, water, organic matter content, etc.). This work represents the first part of the interdisciplinary project "Geological and geochemical control on Radon occurrence and natural radioactivity in the Euganean Hills district (North-Eastern Italy)", aimed at producing detailed results of the actual radiation levels in connection mainly with lithological parameters.A detailed sampling strategy, based on lithostratigraphy, petrology and mineralogy, has been adopted. The 151 rock samples collected were analyzed by high resolution γ-ray spectrometry with ex situ HPGe detectors. Statistical and geostatistical analyses were performed, and outlier values of U and Th – possibly associated with anomalies in the geological formation – were identified. U, Th and K concentration maps were developed using both the entire database and then again after expunging the outliers; the two were then compared. In all maps the highest values can be associated to trachyte and rhyolite lithologies, and the lowest ones to sedimentary formations. The external dose due to natural radionuclides in the soil – the so called terrestrial gamma dose rate – has been calculated using the U, Th and K distribution measured in the bedrock samples.



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Estimation of the radon production rate in granite rocks and evaluation of the implications for geogenic radon potential maps: A case study in Central Portugal

Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): A. Pereira, R. Lamas, M. Miranda, F. Domingos, L. Neves, N. Ferreira, L. Costa
AbstractThe goal of this study was to estimate radon gas production rate in granitic rocks and identify the factors responsible for the observed variability. For this purpose, 180 samples were collected from pre-Hercynian and Hercynian rocks in north and central Portugal and analysed for a) 226Ra activity, b) radon (222Rn) per unit mass activity, and c) radon gas emanation coefficient. On a subset of representative samples from the same rock types were also measured d) apparent porosity and e) apparent density. For each of these variables, the values ranged as follows: a) 15 to 587 Bq kg−1, b) 2 to 73 Bq kg−1, c) 0.01 to 0.80, d) 0.3 to 11.4 % and e) 2530 to 2850 kg m−3. Radon production rate varied between 40 to 1386 Bq m−3 h−1. The variability observed was associated with geologically late processes of low and high temperature which led to the alteration of the granitic rock with mobilization of U and increase in radon 222Rn gas emanation. It is suggested that, when developing geogenic radon potential maps, data on uranium concentration in soils/altered rock should be used, rather than data obtained from unaltered rock.



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Radon measurements in an area of tectonic zone: A case study in Central Slovakia

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): Andrej Mojzeš, František Marko, Barbara Porubčanová, Andrea Bartošová
General overviews of the spatial distribution of radon and other natural radionuclides in the geological basement as commonly presented on regional or country maps tend to offer a low density of information, insufficient for gaining relevant knowledge of the environmental impact, especially in the areas of tectonic zones often assumed to be radon prone and therefore dangerous for the human population. An additional survey, employing radon measurements in soil and indoor air, was carried out seeking to provide a more detailed characterization of the expressive fault zone of the Malá Magura in the Horná Nitra region of Central Slovakia. Eventually, the results of soil 222Rn volume activity measurements along two short profiles crossing the assumed fault line did not reveal any indication of active nature of local tectonics, but merely pointed to an existence of a zone of contact between different types of rocks. The results of indoor radon measurements in dwellings of two villages lying on the studied fault showed values that were lower than those commonly observed on the Slovak territory, ruling out any negative health impact on population. Nevertheless, in order to add new findings to an already well established study of geological structure of the region, the indoor radon data collected through a previous survey require a further analysis.



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Verification of the radiometric map of the Czech Republic

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): Milan Matolín
The radiometric map of the Czech Republic is based on uniform regional airborne radiometric total count measurements (1957–1959) which covered 100% of the country. The airborne radiometric instrument was calibrated to a 226Ra point source. The calibration facility for field gamma-ray spectrometers, established in the Czech Republic in 1975, significantly contributed to the subsequent radiometric data standardization. In the 1990's, the original analogue airborne radiometric data were digitized and using the method of back-calibration (IAEA, 2003) converted to dose rate. The map of terrestrial gamma radiation expressed in dose rate (nGy/h) was published on the scale 1:500,000 in 1995. Terrestrial radiation in the Czech Republic, formed by magmatic, sedimentary and metamorphic rocks of Proterozoic to Quaternary age, ranges mostly from 6 to 245 nGy/h, with a mean of 65.6 ± 19.0 nGy/h. The elevated terrestrial radiation in the Czech Republic, in comparison to the global dose rate average of 54 nGy/h, reflects an enhanced content of natural radioactive elements in the rocks.The 1995 published radiometric map of the Czech Republic was successively studied and verified by additional ground gamma-ray spectrometric measurements and by comparison to radiometric maps of Germany, Poland and Slovakia in border zones. A ground dose rate intercomparison measurement under participation of foreign and domestic professional institutions revealed mutual dose rate deviations about 20 nGy/h and more due to differing technical parameters of applied radiometric instruments. Studies and verification of the radiometric map of the Czech Republic illustrate the magnitude of current deviations in dose rate data. This gained experience can assist in harmonization of dose rate data on the European scale.



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Estimating the terrestrial gamma dose rate by decomposition of the ambient dose equivalent rate

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): P. Bossew, G. Cinelli, M. Hernández-Ceballos, N. Cernohlawek, V. Gruber, B. Dehandschutter, F. Menneson, M. Bleher, U. Stöhlker, I. Hellmann, F. Weiler, T. Tollefsen, P.V. Tognoli, M. de Cort
An extensive network of dose rate monitoring stations continuously measures ambient dose rate across Europe, as part of the EURDEP system. Its purpose is early warning in radiological emergencies and documenting its temporal and spatial evolution. In normal conditions, when there is no contribution to the dose rate signal coming from fresh anthropogenic contamination, the data represent the radiation "background", i.e. the combined natural radiation and existing anthropogenic contamination (by global and Chernobyl fallout). These data are being stored, but have so far not been evaluated in depth, or used for any purpose. In the framework of the EU project 'European Atlas of Natural Radiation' the idea has emerged to exploit these data for generating a map of natural terrestrial gamma radiation. This component contributes to the total radiation exposure and knowing its geographical distribution can help establishing local 'radiation budgets'. A further use could be found in terrestrial dose rate as a proxy of the geogenic radon potential, as both quantities are related by partly the same source, namely uranium content of the ground. In this paper, we describe in detail the composition of the ambient dose equivalent rate as measured by the EURDEP monitors with respect to its physical nature and to its sources in the environment. We propose and compare methods to recover the terrestrial component from the gross signal. This requires detailed knowledge of detector response. We consider the probes used in the Austrian, Belgian and German dose rate networks, which are the respective national networks supplying data to EURDEP. It will be shown that although considerable progress has been made in understanding the dose rate signals, there is still space for improvement in terms of modelling and model parameters. An indispensable condition for success of the endeavour to establish a Europe-wide map of terrestrial dose rate background is progress in harmonising the European dose rate monitoring network.



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Spatial analysis of ambient gamma dose equivalent rate data by means of digital image processing techniques

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): Katalin Zsuzsanna Szabó, Gyozo Jordan, Attila Petrik, Ákos Horváth, Csaba Szabó
A detailed ambient gamma dose equivalent rate mapping based on field measurements at ground level and at 1 m height was carried out at 142 sites in 80 × 90 km area in Pest County, Hungary. Detailed digital image processing analysis was carried out to identify and characterise spatial features such as outlying points, anomalous zones and linear edges in a smoothed TIN interpolated surface. The applied method proceeds from the simple shaded relief model and digital cross-sections to the more complex gradient magnitude and gradient direction maps, 2nd derivative profile curvature map, relief map and lineament density map. Each map is analysed for statistical characteristics and histogram-based image segmentation is used to delineate areas homogeneous with respect to the parameter values in these maps. Assessment of spatial anisotropy is implemented by 2D autocorrelogram and directional variogram analyses. The identified spatial features are related to underlying geological and tectonic conditions using GIS technology. Results show that detailed digital image processing is efficient in revealing the pattern present in field-measured ambient gamma dose equivalent rates and they are related to regional scale tectonic zones and surface sedimentary lithological conditions in the study area.



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The use of mapped geology as a predictor of radon potential in Norway

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): Robin J. Watson, Mark A. Smethurst, Guri V. Ganerød, Ingvild Finne, Anne Liv Rudjord
Radon exposure is considered to cause several hundred fatalities from lung-cancer each year in Norway. A national map identifying areas which are likely to be exposed to elevated radon concentrations would be a useful tool for decision-making authorities, and would be particularly important in areas where only few indoor radon measurements exist. An earlier Norwegian study (Smethurst et al. 2008) produced radon hazard maps by examining the relationship between airborne gamma-ray spectrometry, bedrock and drift geology, and indoor radon. The study was limited to the Oslo region where substantial indoor radon and airborne equivalent uranium datasets were available, and did not attempt to test the statistical significance of relationships, or to quantify the confidence of its predictions. While it can be anticipated that airborne measurements may have useful predictive power for indoor radon, airborne measurement coverage in Norway is at present sparse; to provide national coverage of radon hazard estimates, a good understanding of the relationship between geology and indoor radon is therefore important. In this work we use a new enlarged (n = 34,563) form of the indoor radon dataset with national coverage, and we use it to examine the relationship between geology and indoor radon concentrations. We use this relationship to characterise geological classes by their radon potential, and we produce a national radon hazard map which includes confidence limits on the likelihood of areas having elevated radon concentrations, and which covers the whole of mainland Norway, even areas where little or no indoor radon data are available. We find that bedrock and drift geology classes can account for around 40% of the total observed variation in radon potential. We test geology-based predictions of RP (radon potential) against locally-derived estimates of RP, and produce classification matrices with kappa values in the range 0.37–0.56. Our classifier has high predictive value but suffers from low sensitivities for radon affected areas. We investigate an alternative classification method based on a Naïve Bayes classifier which results in similar overall performance. The work forms part of an ongoing study which will eventually incorporate airborne equivalent uranium data, as and when new airborne data become available.



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Geographically weighted regression and geostatistical techniques to construct the geogenic radon potential map of the Lazio region: A methodological proposal for the European Atlas of Natural Radiation

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): G. Ciotoli, M. Voltaggio, P. Tuccimei, M. Soligo, A. Pasculli, S.E. Beaubien, S. Bigi
In many countries, assessment programmes are carried out to identify areas where people may be exposed to high radon levels. These programmes often involve detailed mapping, followed by spatial interpolation and extrapolation of the results based on the correlation of indoor radon values with other parameters (e.g., lithology, permeability and airborne total gamma radiation) to optimise the radon hazard maps at the municipal and/or regional scale. In the present work, Geographical Weighted Regression and geostatistics are used to estimate the Geogenic Radon Potential (GRP) of the Lazio Region, assuming that the radon risk only depends on the geological and environmental characteristics of the study area. A wide geodatabase has been organised including about 8000 samples of soil-gas radon, as well as other proxy variables, such as radium and uranium content of homogeneous geological units, rock permeability, and faults and topography often associated with radon production/migration in the shallow environment. All these data have been processed in a Geographic Information System (GIS) using geospatial analysis and geostatistics to produce base thematic maps in a 1000 m × 1000 m grid format. Global Ordinary Least Squared (OLS) regression and local Geographical Weighted Regression (GWR) have been applied and compared assuming that the relationships between radon activities and the environmental variables are not spatially stationary, but vary locally according to the GRP. The spatial regression model has been elaborated considering soil-gas radon concentrations as the response variable and developing proxy variables as predictors through the use of a training dataset. Then a validation procedure was used to predict soil-gas radon values using a test dataset. Finally, the predicted values were interpolated using the kriging algorithm to obtain the GRP map of the Lazio region. The map shows some high GRP areas corresponding to the volcanic terrains (central-northern sector of Lazio region) and to faulted and fractured carbonate rocks (central-southern and eastern sectors of the Lazio region). This typical local variability of autocorrelated phenomena can only be taken into account by using local methods for spatial data analysis. The constructed GRP map can be a useful tool to implement radon policies at both the national and local levels, providing critical data for land use and planning purposes.



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Modeling of geogenic radon in Switzerland based on ordered logistic regression

Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): Georg Kropat, François Bochud, Christophe Murith, Martha Palacios (Gruson), Sébastien Baechler
PurposeThe estimation of the radon hazard of a future construction site should ideally be based on the geogenic radon potential (GRP), since this estimate is free of anthropogenic influences and building characteristics. The goal of this study was to evaluate terrestrial gamma dose rate (TGD), geology, fault lines and topsoil permeability as predictors for the creation of a GRP map based on logistic regression.MethodSoil gas radon measurements (SRC) are more suited for the estimation of GRP than indoor radon measurements (IRC) since the former do not depend on ventilation and heating habits or building characteristics. However, SRC have only been measured at a few locations in Switzerland. In former studies a good correlation between spatial aggregates of IRC and SRC has been observed. That's why we used IRC measurements aggregated on a 10 km × 10 km grid to calibrate an ordered logistic regression model for geogenic radon potential (GRP). As predictors we took into account terrestrial gamma doserate, regrouped geological units, fault line density and the permeability of the soil.ResultsThe classification success rate of the model results to 56% in case of the inclusion of all 4 predictor variables. Our results suggest that terrestrial gamma doserate and regrouped geological units are more suited to model GRP than fault line density and soil permeability.ConclusionOrdered logistic regression is a promising tool for the modeling of GRP maps due to its simplicity and fast computation time. Future studies should account for additional variables to improve the modeling of high radon hazard in the Jura Mountains of Switzerland.



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Spanish experience on the design of radon surveys based on the use of geogenic information

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): C. Sainz Fernández, L.S. Quindós Poncela, A. Fernández Villar, I. Fuente Merino, J.L. Gutierrez-Villanueva, S. Celaya González, L. Quindós López, J. Quindós López, E. Fernández, J. Remondo Tejerina, J.L. Martín Matarranz, M. García Talavera
One of the requirements of the recently approved EU-BSS (European Basic Safety Standards Directive, EURATOM, 2013) is the design and implementation of national radon action plans in the member states (Annex XVIII). Such plans require radon surveys. The analysis of indoor radon data is supported by the existing knowledge about geogenic radiation. With this aim, we used the terrestrial gamma dose rate data from the MARNA project. In addition, we considered other criterion regarding the surface of Spain, population, permeability of rocks, uranium and radium contain in soils because currently no data are available related to soil radon gas concentration and permeability in Spain. Given that, a Spanish radon map was produced which will be part of the European Indoor Radon Map and a component of the European Atlas of Natural Radiation. The map indicates geographical areas with high probability of finding high indoor radon concentrations. This information will support legislation regarding prevention of radon entry both in dwellings and workplaces. In addition, the map will serve as a tool for the development of strategies at all levels: individual dwellings, local, regional and national administration.



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Bagged neural network model for prediction of the mean indoor radon concentration in the municipalities in Czech Republic

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): Jana Timkova, Ivana Fojtikova, Petra Pacherova
The purpose of the study is to determine radon-prone areas in the Czech Republic based on the measurements of indoor radon concentration and independent predictors (rock type and permeability of the bedrock, gamma dose rate, GPS coordinates and the average age of family houses). The relationship between the mean observed indoor radon concentrations in monitored areas (∼22% municipalities) and the independent predictors was modelled using a bagged neural network. Levels of mean indoor radon concentration in the unmonitored areas were predicted using the bagged neural network model fitted for the monitored areas. The propensity to increased indoor radon was determined by estimated probability of exceeding the action level of 300Bq/m3.



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Correlation analysis of the natural radionuclides in soil and indoor radon in Vojvodina, Province of Serbia

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Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): S. Forkapic, D. Maletić, J. Vasin, K. Bikit, D. Mrdja, I. Bikit, V. Udovičić, R. Banjanac
The most dominant source of indoor radon is the underlying soil, so the enhanced levels of radon are usually expected in mountain regions and geology units with high radium and uranium content in surface soils. Laboratory for radioactivity and dose measurement, Faculty of Sciences, University of Novi Sad has rich databases of natural radionuclides concentrations in Vojvodina soil and also of indoor radon concentrations for the region of Vojvodina, Northern Province of Serbia. In this paper we present the results of correlative and multivariate analysis of these results and soil characteristics in order to estimate the geogenic radon potential. The correlative and multivariate analysis were done using Toolkit for Multivariate Analysis software package TMVA package, within ROOT analysis framework, which uses several comparable multivariate methods for our analysis. The evaluation ranking results based on the best signal efficiency and purity, show that the Boosted Decision Trees (BDT) and Multi Layer Preceptor (MLP), based on Artificial Neural Network (ANN), are multivariate methods which give the best results in the analysis. The BDTG multivariate method shows that variables with the highest importance are radio-nuclides activity on 30 cm depth. Moreover, the multivariate regression methods give a good approximation of indoor radon activity using full set of input variables. On several locations in the city of Novi Sad the results of indoor radon concentrations, radon emanation from soil, gamma spectrometry measurements of underlying soil and geology characteristics of soil were analyzed in detail in order to verify previously obtained correlations for Vojvodina soil.



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Residential, soil and water radon surveys in north-western part of Romania

Publication date: January 2017
Source:Journal of Environmental Radioactivity, Volume 166, Part 2
Author(s): Alexandra Cucoş (Dinu), Botond Papp, Tiberius Dicu, Mircea Moldovan, Denissa Bety Burghele, Ionuţ Tudor Moraru, Ancuţa Tenţer, Constantin Cosma
The exposure to radon and radon decay products in homes and at workplaces represents the greatest risk from natural ionizing radiation. The present study brings forward the residential, soil and water radon surveys in 5 counties of Romania. Indoor radon measurements were performed by using CR-39 track detectors exposed for 3 months on ground-floor level of dwellings, according to the NRPB Measurements Protocol. Radon concentrations in soil and water were measured using the LUK3C device. The indoor radon concentrations ranged from 5 to 2592 Bq⋅m−3 with an updated preliminary arithmetic mean of 133 Bq⋅m−3, and a geometric mean of 90 Bq⋅m−3. In about 6% of the investigated grid cells the indoor radon concentrations exceed the threshold of 300 Bq⋅m−3. The soil gas radon concentration varies from 0.8 to 169 kBq⋅m−3, with a geometric mean of 28.4 kBq⋅m−3. For water samples, the results show radon concentrations within the range of 0.3–352 kBq⋅m−3 with a geometric mean of 7.7 Bq⋅L−1. The indoor radon map was plotted on a reference grid developed by JRC with the resolution 10 × 10 km2.



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Effect of laser acupuncture in mild benign hypertensive female patients

2016-11-29T16-49-37Z
Source: International Journal of Health and Rehabilitation Sciences (IJHRS)
Mohamed K. Seyam, Ghada M. Shawky.
Background: Recent studies have found that acupuncture treatments lower blood pressure. Acupuncture is a traditional Chinese medical technique of inserting needles at particular points on the body to balance the opposing forces of yin and yang and the smooth flow of qi. Laser acupoint technique is considers as saving time because it is performed in less time than needles acupuncture. Purpose: The aim of this study was to study the effect of laser acupuncture on lowering the primary type of hypertension in old female adults. Materials and Methods: Thirty female mild hypertensive patients with ranged age 50-59 years were enrolled in the study. Systolic and diastolic blood pressure evaluated by Mercury sphygmomanometer. Baseline blood pressure measured for each subject prior to the initiation of the treatment and after enrolled in of treatment program. The anthropometric data including age, duration of hypertension, height, weight and body mass index (BMI) was collected for both experimental and six weeks control groups. Results: after treating hypertension patients by the laser acupuncture for 6 weeks (twice per week session), both the systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased significantly (P

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Effect of Recasting of Ni-Cr Base Metal Dental Casting Alloys on the Corrosion Rate, Compositional Changes and Ion Release in Artificial Saliva and Saline Solution

2016-11-29T16-49-37Z
Source: International Journal of Health and Rehabilitation Sciences (IJHRS)
K Jayaprakash, K Harish Kumar Shetty, A Nityananda Shetty, Bantarahalli Thopegowda Nandish, Sowmya Rao.
Background: Environmental concerns are increasing rapidly, and the industry and public are more concerned about natural resources and recycling. Today, it is equally important to take into account cost, ecological factors in production and recycling of materials used in various fields. Purpose: The aim of this study was to evaluate corrosion rate, compositional changes and ion release of recasted Ni-Cr dental casting alloy Materials and Methods: Commercially available Ni -Cr alloy (Bellabond) was used in the study. The recasting was done without any addition of new alloys and recasted up to six times. Corrosion rate was determined by Tafel extrapolation method in artificial saliva in pH 2.3, 6.7 and in 0.9% saline solution at pH 7.3. The compositional changes were studied by Inductively coupled Plasma Atomic emission Spectroscopy (ICP-AES) method. Ion release during storage in artificial saliva and saline solution for one week and four weeks was detected by using atomic absorption spectroscopy (AAS). Results: The corrosion rate was found slightly increased with recasting numbers up to six times. The quantities of ions released increased as the recasting number increases. These changes were not clinically significant. During recasting procedure, there was a change in their alloy compositions, which increases the corrosion rate in recasted alloys. Conclusion: The recasting technique can be accepted in dental practices. This study showed the possibilities of safe usage of recasted alloys up to certain generations in dentistry and in later stages if it is not suitable for dentistry it can be directed to other fields of industries, where the biocompatibility is not a major requirement. This lowers the environmental burden, health hazards and protects imbalance of natural resources.


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Appraise the Health-Related Quality of Life among Trauma Patients

2016-11-29T16-49-37Z
Source: International Journal of Health and Rehabilitation Sciences (IJHRS)
Ravi Kant Jain, Neelesh Dhadse, Chirag Sethi, Ravindra Kumar, Susmit Kosta.
Background: Limb injures is revolve a life-changing event that can cause significant disruptions in many important areas of life. Objectives: The objective of our study was to appraise the Health Related Quality of Life (HRQOL) and psychosocial factors associated with pain and disability in patients following Upper limb (UL) and lower limb (LL) trauma patients Materials and methods: A sample of convenience 300 adult male and female patients who met the inclusion criteria was included. A short form (36) health status questionnaire was filled by a single author from each patient after one year of follow up. This part was utilized to assess the QOL among limbs traumas patients. Results: Intraclass correlation coefficients were greater than 0.7 in five of the eight domains of SF 36 except mental health, social function and general health. Chronbachs α was higher the 0.8 all the domains except in social function domain. There was no difference in Health Related Quality of Life in patients with upper and lower limb trauma. However there was significant difference in 4 domains related to physical components of SF 36 survey form between male and females. Conclusion: Both upper and lower limb trauma similarly affects the Health Related Quality of Life in all age group of patients.


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Determination of insertion depth of flexible laryngeal mask airway in pediatric population—A prospective observational study

The purpose of this study was to determine the ideal insertion depth of the flexible laryngeal mask airway (FLMA) by elucidating the relationships between insertion depth and patient's age, body weight, height, and other parameters. We also evaluated an insertion technique that uses the change in intracuff pressure for proper positioning of the FLMA in cases where it is difficult to sense resistance during FLMA insertion.

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Mutations in IL36RN are associated with geographic tongue

Abstract

Geographic tongue (GT) is a benign inflammatory disorder of unknown etiology. Epidemiology and histopathology in previous studies found that generalized pustular psoriasis (GPP) is a factor associated with GT, but the molecular mechanism remains obscure. To investigate the mechanism of GT, with and without GPP, three cohorts were recruited to conduct genotyping of IL36RN, which is the causative gene of GPP. In a family spanning three generations and diagnosed with only GT ("GT alone"), GT was caused by the c.115+6T>C/p.Arg10ArgfsX1 mutation in the IL36RN gene. An autosomal dominant inheritance pattern with incomplete penetrance was observed. In the cohort consisting of sporadic cases of "GT alone" (n = 48), significant associations between GT and three IL36RN variants (c.115+6T>C/p.Arg10ArgfsX1, c.169G>A/p.Val57Ile and c.29G>A/p.Arg10Gln) were shown. In the GPP patient cohort (n = 56) and GPP family member cohort (n = 67), a significant association between the c.115+6T>C mutation and the simultaneous presence of GPP and GT was observed when compared to the presence of GPP without GT (P < 0.05). Biopsies revealed similarities among GT patients with different genotypes (AA, Aa and aa), with the neutrophils prominently infiltrating the epidermis. Western-blot analysis showed that the expression ratio of IL-36Ra/IL-36γ in lesioned tongues with individuals harboring different genotypes (AA, Aa and aa, n = 3, respectively) decreased significantly compared to controls (n = 3). We describe the mechanism of GT for the first time: some cases of GT are caused by IL36RN mutations, while those lacking mutations are associated with an imbalance in expression between IL-36Ra and IL-36γ proteins in tongue tissue.



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Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression [Genetics]

Triple-negative breast cancer (TNBC) has the worst prognosis of any breast cancer subtype. To better understand the genetic forces driving TNBC, we performed a transposon mutagenesis screen in a phosphatase and tensin homolog (Pten) mutant mice and identified 12 candidate trunk drivers and a much larger number of progression genes....

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Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells [Genetics]

Rereplication generates double-strand breaks (DSBs) at sites of fork collisions and causes genomic damage, including repeat instability and chromosomal aberrations. However, the primary mechanism used to repair rereplication DSBs varies across different experimental systems. In Drosophila follicle cells, developmentally regulated rereplication is used to amplify six genomic regions, two of...

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Duplication of chicken defensin7 gene generated by gene conversion and homologous recombination [Genetics]

Defensins constitute an evolutionary conserved family of cationic antimicrobial peptides that play a key role in host innate immune responses to infection. Defensin genes generally reside in complex genomic regions that are prone to structural variation, and defensin genes exhibit extensive copy number variation in humans and in other species....

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Associations of MMP-2 −1306 C/T and MMP-9 −1562 C/T polymorphisms with breast cancer risk among different populations: a meta-analysis

Abstract

The meta-analysis aims to investigate association between two matrix metalloproteinases (MMPs) polymorphisms (MMP-2 −1306 C/T and MMP-9 −1562 C/T) and breast cancer risk. Eligible studies were retrieved from relevant databases, based on predefined criteria. Quality assessment was evaluated by Newcastle–Ottawa Scale. Odds ratio (OR) with its 95% confidence interval (CI) was selected as the effect size for the meta-analysis. As a result, 13 studies were included. MMP-2 −1306 C/T polymorphism was not significantly associated with breast cancer risk under all genetic models (P > 0.05). However, subgroup analysis stratified by ethnicity showed a significant association between MMP-2 −1306 C/T polymorphism and reduced breast cancer risk in Asian populations under allelic model (OR 0.60, 95% CI 0.39–0.90, P = 0.02) and dominant model (OR 0.55, 95% CI 0.34–0.89, P = 0.02). MMP-9 −1562 C/T polymorphism was significantly related to increased breast cancer risk under allelic model (OR 1.50, 95% CI 1.06–2.12, P = 0.02), additive model (OR 1.45, 95% CI 1.02–2.05, P = 0.04) and recessive model (OR 1.54, 95% CI 1.13–2.12, OR 0.007). A significant association between MMP-9 −1562 C/T polymorphism and increased breast cancer risk in Caucasian was detected under most of the genetic models (P < 0.05). MMP-2 −1306 C/T polymorphism might be significantly associated with reduced breast cancer risk in Asian, while MMP-9 −1562 C/T might be closely related to increased breast cancer risk, especially in Caucasian.



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Reality Training: Handguns in the fire service

Chief Wylie discusses a host of issues surrounding firefighters being armed. If you're going to carry a weapon on duty, one of your primary jobs has to be care and custody of that weapon.

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EMT student shot, run over while aiding shooting victim

By Bryn Stole
The Advocate

BATON ROUGE, La. — A 17-year-old Central High senior is in the hospital with a list of painful injuries — a pair of bullet wounds, a broken arm and a broken leg — after being shot and run over twice Sunday evening while trying to save a woman fatally shot on Essen Lane.

Daniel Wesley, a trained emergency medical responder who's currently studying for his EMT certification, spotted 30-year-old April Peck lying in the roadway while driving home from a shopping trip at the Mall of Louisiana, said his mother, Kathy Wesley.

The son of a retired East Baton Rouge EMT, Wesley pulled to the side of the road, grabbed his father's medic bag and rushed to the woman, who'd been shot and tossed from her car minutes earlier by her 48-year-old boyfriend, Terrell Walker.

Daniel Wesley pulled on a pair of gloves and was preparing to put pressure on the woman's bullet wound when Walker came speeding back, aiming his car for Wesley and a group of other passers-by — including a physician and the crew of an EMS ambulance — who'd also stopped to help.

The impact threw Wesley against the ambulance, his mother said, shattering his arm. Then Walker stepped out of Peck's Chevy Malibu and shot Wesley.

"If you help her, I'm going to kill you," Kathy Wesley said Walker told her son as he turned to chase after the others trying to save Peck's life.

Wesley managed to crawl away toward the Essen Lane median, his mother said, but when Walker returned he shot him again, then climbed in his car and ran over Wesley a second time as he attempted to escape.

The ordeal left Wesley, who was rushed along with Peck to Our Lady of the Lake Regional Medical Center, with a shattered right arm, a broken thigh bone and a pair of gunshot wounds from bullets that passed straight through his body, his mother said.

Peck was pronounced dead not long afterward. Walker, the gunman, died later Sunday night in a shootout with East Baton Rouge sheriff's deputies.

Wesley spent part of Sunday night in surgery to place rods and pins around his broken femur, Kathy Wesley said. A second surgery to repair his shattered arm is scheduled for Tuesday.

"He's a tough kid. He's silly and has a sense of humor you wouldn't believe," she said. "He's cracking jokes and trying his best to keep the pain in. He's been surrounded by friends and family all afternoon."

Copyright 2016 The Advocate



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EMTs: Don't just do something, stand there

In every resuscitation room at one of our local emergency departments, there are large, comfortable wooden rocking chairs. They aren't for family or mothers comforting their children. In fact, they look like they belong on the front porch of your local Cracker Barrel, occupied by elderly folks playing checkers while they digest their meals.

They are not something one expects to find in a modern emergency department decorated in glass, tile and stainless steel. But they have a very real purpose.

During a cardiac arrest or critical trauma, the physician sits in the chair and manages the resuscitation. They don't actively participate, unless the resuscitation requires a procedure only a physician can perform. The chair allows them to be objective and dispassionately consider what needs to be done next, without being tied up in the mechanics of how it gets done.

One of the best emergency physicians I have ever met works a resuscitation by standing off to one side at the foot of the bed, arms folded across her chest, sometimes speculatively tapping her chin with a finger. Rarely does she do an intervention herself.

The respiratory therapists intubate, nurses get the vascular access and provide most of the interventions and care. Occasionally, she'll step out of her place at the foot of the bed and start a central line or insert a chest tube. Mainly, she quietly asks questions and gives orders, occasionally pointing at someone like a maestro conducting a symphony.

She does not raise her voice. There is no drama, her voice as even and conversational as if she were ordering lunch at her favorite bistro. It would probably make for very boring television, but I could easily envision her in one of those rocking chairs, orchestrating a complex resuscitation while she knits a sweater.

She knew that often, the best approach is not to just do something, but to stand there.

When I wrote about being the stand-back, big-picture, non-interventional paramedic, I pointed out that the maturation of an EMS provider is often reflected in the restraint he practices, but let's not forget the first two parts of that description: stand back and big picture. A brief pause in the doorway to dispassionately consider what you're seeing and what needs to be done is more important than doing something immediately. If your role on a scene is to be the EMT in charge, you're being paid for what goes on between your ears rather than what you do with your hands.

Don't just do something, stand there
In my experience, that seems to be one of the biggest hurdles for new medics to clear; how to transition from being one of the dancers to choreographing the entire routine.

What got me ruminating on the subject was a story related by a colleague, who was called to back up a flight medic and a ground crew on a challenging call. What he walked in on was a call about to go south in a big way, and much of it due to the proposed course of treatment by two experienced, otherwise talented paramedics.

The patient was an adolescent girl with difficulty breathing and a history of asthma. The ground medic, presented with this information from dispatch, fell prey to confirmation bias as soon as he made patient contact, and promptly went down the status asthmaticus pathway with scarcely a thought as to other differential diagnoses. When the flight medic arrived and was briefed by the ground crew, he promptly fell victim to the bandwagon effect and agreed that this was indeed the worst case of asthma in the history of ever.

Tachycardia? Check.

Tachypnea? Check.

Chest tightness? Check.

Wheezes and diminished lung sounds? Check.

Anxiety and restlessness indicative of hypoxia? Check.

They were so sure of themselves that they had already given an albuterol/ipratropium nebulizer, an IV injection of methylprednisolone, and were getting ready to hang a magnesium sulfate drip and administer 0.3 mg of epinephrine.

When my colleague arrived, because he was the third-in medic and the fourth EMS crewmember in the room, he didn't do anything. He just stood there and took it all in.

… and noticed what had escaped everyone else's attention; her heart rate was 270.

Now, an asthma attack may elevate your heart rate, as will a beta-adrenergic medication like albuterol, but it isn't likely to cause a heart rate of 270.

One emergent synchronized cardioversion later, the patient was dramatically improved, and once everyone took a moment to think, they realized her "asthma attack" was not an asthma attack at all. She was in respiratory distress due to an unstable tachycardia, and two experienced paramedics were left to contemplate the dangers of tunnel vision and what might have happened in they gave their Wolff-Parkinson-White patient a dose of epinephrine.

The ground crew and the flight medic let the panicky school staff and the gravity of the patient's condition get inside their OODA Loop, and from then on, were too busy reacting to each new piece of information to see where it fit in the patient's clinical presentation. The school nurse and principal said asthma, and the patient was too distressed to talk. She had already had two doses of her inhaler without improvement, which is why they summoned EMS. Everyone in the room was screaming at them, "Don't just stand there, DO something!"

And so they did. The wrong thing.

The lesson we can learn is there are few interventions so urgent that they must be done without sufficient information; information to guide the intervention, information to determine which intervention is appropriate, information to determine if the last interventions was effective and yes, information to determine whether any intervention is needed in the first place.

Scene sense to think fast
I have often jokingly said that paramedics do not run. Paramedics mosey. We saunter, we stroll and we occasionally swagger when we can't keep our egos in check. But we do not run. The reason is twofold: we want to convey the impression that the emergency ends when we arrive, and we never want to move faster than we can think.

I think pretty fast. When the situation demands, I can move much faster than you'd think possible for a guy my size. Funny thing is, I have discovered that the faster (and better) I think, the less I encounter situations that demand I move fast. The same was true when I played volleyball in college (intramural, my school didn't have a men's NCAA team). I was never the most athletically gifted person on the floor, but I found myself in the proper position more often than not to make a play. I didn't have to be athletically gifted, because I had court sense.

There are myriad clichés devoted to this concept, like "slow is smooth, smooth is fast," or "when you find yourself ass-deep in alligators, it is hard to remember that the original objective was to drain the swamp," but sayings become clichés because they hold a grain of truth.

When you find yourself overwhelmed by events and it feels as if your thought processes are mired in molasses, slow down. That pause to reflect and dispassionately consider your next act is often all it takes to allow you to manage your scene, instead of your scene managing you.

Don't just do something, stand there.



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Does Elite Sport Degrade Sleep Quality? A Systematic Review

Abstract

Background

Information on sleep quality and insomnia symptomatology among elite athletes remains poorly systematised in the sports science and medicine literature. The extent to which performance in elite sport represents a risk for chronic insomnia is unknown.

Objectives

The purpose of this systematic review was to profile the objective and experienced characteristics of sleep among elite athletes, and to consider relationships between elite sport and insomnia symptomatology.

Methods

Studies relating to sleep involving participants described on a pre-defined continuum of 'eliteness' were located through a systematic search of four research databases: SPORTDiscus, PubMed, Science Direct and Google Scholar, up to April 2016. Once extracted, studies were categorised as (1) those mainly describing sleep structure/patterns, (2) those mainly describing sleep quality and insomnia symptomatology and (3) those exploring associations between aspects of elite sport and sleep outcomes.

Results

The search returned 1676 records. Following screening against set criteria, a total of 37 studies were identified. The quality of evidence reviewed was generally low. Pooled sleep quality data revealed high levels of sleep complaints in elite athletes. Three risk factors for sleep disturbance were broadly identified: (1) training, (2) travel and (3) competition.

Conclusion

While acknowledging the limited number of high-quality evidence reviewed, athletes show a high overall prevalence of insomnia symptoms characterised by longer sleep latencies, greater sleep fragmentation, non-restorative sleep, and excessive daytime fatigue. These symptoms show marked inter-sport differences. Two underlying mechanisms are implicated in the mediation of sport-related insomnia symptoms: pre-sleep cognitive arousal and sleep restriction.



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EMTs: Don't just do something, stand there

In every resuscitation room at one of our local emergency departments, there are large, comfortable wooden rocking chairs. They aren't for family or mothers comforting their children. In fact, they look like they belong on the front porch of your local Cracker Barrel, occupied by elderly folks playing checkers while they digest their meals.

They are not something one expects to find in a modern emergency department decorated in glass, tile and stainless steel. But they have a very real purpose.

During a cardiac arrest or critical trauma, the physician sits in the chair and manages the resuscitation. They don't actively participate, unless the resuscitation requires a procedure only a physician can perform. The chair allows them to be objective and dispassionately consider what needs to be done next, without being tied up in the mechanics of how it gets done.

One of the best emergency physicians I have ever met works a resuscitation by standing off to one side at the foot of the bed, arms folded across her chest, sometimes speculatively tapping her chin with a finger. Rarely does she do an intervention herself.

The respiratory therapists intubate, nurses get the vascular access and provide most of the interventions and care. Occasionally, she'll step out of her place at the foot of the bed and start a central line or insert a chest tube. Mainly, she quietly asks questions and gives orders, occasionally pointing at someone like a maestro conducting a symphony.

She does not raise her voice. There is no drama, her voice as even and conversational as if she were ordering lunch at her favorite bistro. It would probably make for very boring television, but I could easily envision her in one of those rocking chairs, orchestrating a complex resuscitation while she knits a sweater.

She knew that often, the best approach is not to just do something, but to stand there.

When I wrote about being the stand-back, big-picture, non-interventional paramedic, I pointed out that the maturation of an EMS provider is often reflected in the restraint he practices, but let's not forget the first two parts of that description: stand back and big picture. A brief pause in the doorway to dispassionately consider what you're seeing and what needs to be done is more important than doing something immediately. If your role on a scene is to be the EMT in charge, you're being paid for what goes on between your ears rather than what you do with your hands.

Don't just do something, stand there
In my experience, that seems to be one of the biggest hurdles for new medics to clear; how to transition from being one of the dancers to choreographing the entire routine.

What got me ruminating on the subject was a story related by a colleague, who was called to back up a flight medic and a ground crew on a challenging call. What he walked in on was a call about to go south in a big way, and much of it due to the proposed course of treatment by two experienced, otherwise talented paramedics.

The patient was an adolescent girl with difficulty breathing and a history of asthma. The ground medic, presented with this information from dispatch, fell prey to confirmation bias as soon as he made patient contact, and promptly went down the status asthmaticus pathway with scarcely a thought as to other differential diagnoses. When the flight medic arrived and was briefed by the ground crew, he promptly fell victim to the bandwagon effect and agreed that this was indeed the worst case of asthma in the history of ever.

Tachycardia" Check.

Tachypnea" Check.

Chest tightness" Check.

Wheezes and diminished lung sounds" Check.

Anxiety and restlessness indicative of hypoxia" Check.

They were so sure of themselves that they had already given an albuterol/ipratropium nebulizer, an IV injection of methylprednisolone, and were getting ready to hang a magnesium sulfate drip and administer 0.3 mg of epinephrine.

When my colleague arrived, because he was the third-in medic and the fourth EMS crewmember in the room, he didn't do anything. He just stood there and took it all in.

… and noticed what had escaped everyone else's attention; her heart rate was 270.

Now, an asthma attack may elevate your heart rate, as will a beta-adrenergic medication like albuterol, but it isn't likely to cause a heart rate of 270.

One emergent synchronized cardioversion later, the patient was dramatically improved, and once everyone took a moment to think, they realized her "asthma attack" was not an asthma attack at all. She was in respiratory distress due to an unstable tachycardia, and two experienced paramedics were left to contemplate the dangers of tunnel vision and what might have happened in they gave their Wolff-Parkinson-White patient a dose of epinephrine.

The ground crew and the flight medic let the panicky school staff and the gravity of the patient's condition get inside their OODA Loop, and from then on, were too busy reacting to each new piece of information to see where it fit in the patient's clinical presentation. The school nurse and principal said asthma, and the patient was too distressed to talk. She had already had two doses of her inhaler without improvement, which is why they summoned EMS. Everyone in the room was screaming at them, "Don't just stand there, DO something!"

And so they did. The wrong thing.

The lesson we can learn is there are few interventions so urgent that they must be done without sufficient information; information to guide the intervention, information to determine which intervention is appropriate, information to determine if the last interventions was effective and yes, information to determine whether any intervention is needed in the first place.

Scene sense to think fast
I have often jokingly said that paramedics do not run. Paramedics mosey. We saunter, we stroll and we occasionally swagger when we can't keep our egos in check. But we do not run. The reason is twofold: we want to convey the impression that the emergency ends when we arrive, and we never want to move faster than we can think.

I think pretty fast. When the situation demands, I can move much faster than you'd think possible for a guy my size. Funny thing is, I have discovered that the faster (and better) I think, the less I encounter situations that demand I move fast. The same was true when I played volleyball in college (intramural, my school didn't have a men's NCAA team). I was never the most athletically gifted person on the floor, but I found myself in the proper position more often than not to make a play. I didn't have to be athletically gifted, because I had court sense.

There are myriad clichés devoted to this concept, like "slow is smooth, smooth is fast," or "when you find yourself ass-deep in alligators, it is hard to remember that the original objective was to drain the swamp," but sayings become clichés because they hold a grain of truth.

When you find yourself overwhelmed by events and it feels as if your thought processes are mired in molasses, slow down. That pause to reflect and dispassionately consider your next act is often all it takes to allow you to manage your scene, instead of your scene managing you.

Don't just do something, stand there.



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Reality Training: Handguns in the fire service

Chief Wylie discusses a host of issues surrounding firefighters being armed. If you're going to carry a weapon on duty, one of your primary jobs has to be care and custody of that weapon.

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Reality Training: Handguns in the fire service

Chief Wylie discusses a host of issues surrounding firefighters being armed. If you're going to carry a weapon on duty, one of your primary jobs has to be care and custody of that weapon.

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Reality Training: Handguns in the fire service

Chief Wylie discusses a host of issues surrounding firefighters being armed. If you're going to carry a weapon on duty, one of your primary jobs has to be care and custody of that weapon.

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An epidemiological study on tobacco use in urban Shimoga, Karnataka

2016-11-29T07-29-39Z
Source: International Journal of Medical Science and Public Health
Kanchana Nagendra, Mangala Belur, Nandini C.
Background: Tobacco is commonly smoked or chewed or inhaled. Smoking is a leading cause of many non-communicable diseases (NCDs) as well as has significant adverse effects on pregnancy. About 1.3 billion people worldwide smoke, and the number of smokers continues to rise. More than 40% of the worlds smokers live in just two countries, i.e. China and India. India only has around 10% of worlds smokers. Objectives: To assess the prevalence of use of different forms of tobacco in urban population of Shimoga. Materials and Methods: A cross-sectional study was conducted in urban Shimoga study was conducted during February 1, 2016, to July 30, 2016, for 6 months. Data were collected from household members aged 15-64 years. The calculated sample size was 2000. Participants were interviewed using a pre-structured and pre-tested questionnaire adapted from the WHO Steps I and II, approaches for NCDs risk factors surveillance, after modifying to suit the local requirements (questions about tobacco use were considered for the study). Results: The prevalence of current smoking in the free-living population of urban city was 15.3%; among them, almost all subjects were daily smokers (prevalence - 15.2%). The prevalence of daily smoking habit was 30.1% among male users. The study revealed that 17.7% of the subjects were current oral tobacco users, while a few were former chewers (0.4%). Conclusion: This community based study demonstrated high prevalence of tobacco use among productive population of urban Shimoga.


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A community-based study on prevalence of hypertension in urban Shimoga, Karnataka

2016-11-29T07-29-39Z
Source: International Journal of Medical Science and Public Health
Kanchana Nagendra, Anirudh Krishna Menon, Mangala Belur, Nandini C.
Background: It is one of the major and independent risk factors for non-communicable diseases (NCD) such as cerebrovascular disease, coronary heart disease, and cardiac and renal failure. The recent WHO report states that considering the prevalence of any diseases, hypertension ranks fourth in the world. Objectives: To assess the prevalence of hypertension in an urban population of Shivamogga. Materials and Methods: A cross-sectional study was conducted in Urban Shivamogga Study was conducted during February 1st to July 30th 2016 for 6 months. Data were collected from household members aged 15-64 years. The calculated sample size was 2000. Subjects were interviewed using a prestructured and pretested questionnaire adopted from WHO Steps I and II, approaches for NCD risk factors surveillance, after modifying to suit the local requirements (questions about hypertension were considered for study). Results: The prevalence of high blood pressure in the present study was 26.5%, which was more prevalent in males (27.6%) compared females (25.3%). History of hypertension in the present study was 12.05%. This is finding is consonance with a study conducted by Nath et al. Conclusion: This community-based study demonstrated high prevalence of Hypertension among productive population of urban Shivamogga.


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Occupational health status of construction workers: A review

2016-11-29T07-29-39Z
Source: International Journal of Medical Science and Public Health
Gourab Biswas, Arkajit Bhattacharya, Rina Bhattacharya.
In the development of a country, construction industry has a significant role. About 350 million people of the world are directly involved in this sector, and the number is growing at a fast rate in the cities. Due to several occupational health risks, this sector is placed top of the list according to workplace accidents and injuries. Workers of this sector expose several types of fatal occupational health hazards daily. Moreover, socioeconomically poor people, particularly from rural areas, are engaged in this sector. Research on occupational health is highly needed to give safety and awareness to the mason workers. Present work is a review of researches from the available published articles to get a broad spectrum of occupational health problems of construction workers. Standard databases are used to collect articles on occupation, health, and working environment. Musculoskeletal disorders are very common among the construction workers. Workplace injuries are mainly due to improper use of personal protective equipments.


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A Comparative Study Of Thoracic Epidural Anaesthesia Using Bupivacaine And General Anaesthesia For Elective Breast Surgeries.

2016-11-29T07-13-36Z
Source: The Southeast Asian Journal of Case Report and Review
Manoj Sahu, Ladhu Lakra, Usha Suwalka, Azzizul Haq.
Introduction And Aim: Major surgery induced profound physiological changes in the perioperative period, characterized by increases in sympathoadrenal and other neuroendocrine activity and also increased cytokine production. Because epidural anesthesia can attenuate this stress response to surgery, improve the quality of postoperative analgesia in comparison with systemic opioids, and hasten recovery of gut function, it has been suggested that conducting surgery under epidural anesthesia (either as the sole anesthetic or in combination with general anesthesia) may reduce perioperative morbidity and mortality compared with general anesthesia alone. This clinical study was therefore under taken to evaluate the usefulness of employing the thoracic segmental epidural blocks for various breast surgeries. Method: The study included 60 patients of elective breast surgeries of age group 20 to 60 years after approval from institutional ethic committee. Informed written consent from all patients was taken. After thorough pre anesthetic check up and premedication in 30 patients of group T Epidural catheter was inserted at T5-6 level and 10 CC of 0.25% bupivacaine were injected for all patients and in 30 patients of group G conventional general anesthesia were given. The parameter studied were 1.Intra operative hemodynamic changes 2. Post operative analgesia 3. Post operative side effects shivering, nausea and vomiting, backache and respiratory effect 4. Recovery time and 5. Duration of hospital stay. Result: Baseline demographic variables were similar in two groups. Intra operative hemodynamic changes were significant in early perioperative period in both groups. There was higher incidence of post operative side effects and intravenous analgesic requirement in group G compared to group T. Recovery time and duration of hospital stay were also higher in group G compared to group T. Conclusion: Thoracic epidural anesthesia compared to general anesthesia has different sets of intra operative hemodynamic changes. In both type of anesthesia this intra operative hemodynamic changes are easily manageable. Thoracic epidural has better postoperative outcome with much better post operative pain management which leads to decrease in recovery time and duration of hospital stay. So it can be considered that thoracic epidural anesthesia is better alternative for elective breast surgeries than general anesthesia.


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Functional magnetic resonance imaging for In Vivo quantification of pulmonary hypertension in the Sugen 5416/hypoxia mouse

Abstract

Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary artery pressures and right heart failure. PAH mouse models are instrumental in understanding disease pathophysiology. However, few methods are available to evaluate right cardiac function in small animals. In this study, magnetic resonance imaging (MRI) was used to measure in vivo cardiac dimensions in the Sugen 5416/hypoxia mouse model. Pulmonary hypertension (PH) was induced in C57BL/6 mice by three weeks of exposure to 10% oxygen and VEGF receptor inhibition (20 mg kg−1 SU5416). Control mice were housed in room air and received vehicle (DMSO). Right ventricle pressures (RVP) were recorded with a pressure-conductance transducer. Short axis contiguous 1 mm thick slices were acquired through the heart and great vessels using a Fast Low Angle SHot (FLASH)-cine sequence. Thirteen images were collected throughout each cardiac cycle. RV systolic pressure was elevated in PH mice (23.6 ± 6 vs. 41.0 ± 11 mmHg, control vs. PH, respectively; P < 0.001, n = 5–11). RV wall thickness was greater in PH mice than control at end-diastole (0.30 ± 0.05 vs. 0.48 ± 0.06 mm, control vs. PH, respectively; P < 0.01, n = 6), but measurements were not different at end-systole (control vs. PH, 0.59 ± 0.11 vs. 0.70 ± 0.11 mm, respectively). RV ejection fraction was decreased in PH mice (72 ± 3 % vs. 58 ± 5 %, control vs. PH, respectively, P < 0.04, n = 6). These data demonstrate that MRI is a precise method to longitudinally monitor right ventricle remodeling and cardiac output in mice models of PH.

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Adipose tissue inflammation by intermittent hypoxia: Mechanistic link between obstructive sleep apnoea and metabolic dysfunction

Abstract

Obstructive sleep apnoea (OSA) is a highly prevalent condition and recognized as a major public health burden conveying a significant risk of cardiometabolic diseases and mortality. Type 2 diabetes (T2D), insulin resistance (IR) and glucose tolerance are common in subjects with OSA and this association is at least in part independent of the effects of obesity. Continuous positive airway pressure (CPAP) is the treatment of choice for the majority of patients with OSA but the benefit of CPAP on glycaemic health is uncertain. Thus, a greater understanding of the mechanisms by which OSA leads to metabolic dysfunction might identify novel therapeutic approaches. Intermittent hypoxia (IH), a hallmark feature of OSA, likely plays a key role in the pathogenesis and experimental studies using animal and in vitro models suggest that IH leads to pancreatic β-cell dysfunction and to insulin resistance in the insulin target organs liver, skeletal muscle and adipose tissue. In particular, IH induces a pro-inflammatory phenotype of the visceral adipose tissue with polarization of adipose tissue macrophages towards a M1 pro-inflammatory subtype, upregulation and secretion of numerous pro-inflammatory adipokines and subsequent impairment of the insulin-signalling pathway, changes which bear a striking similarity to adipose tissue dysfunction seen in obesity. In this review, the available evidence linking IH with metabolic dysfunction is explored with a special emphasis on the adipose tissue in this process.

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Risk perception and practice towards road traffic safety among medical students

2016-11-29T04-51-50Z
Source: International Journal of Community Medicine and Public Health
Syed Hasan Nawaz Zaidi, Pandab Chandra Paul, Pankaj Mishra, Ankur Srivastav.
Background: Road traffic injuries are a major but neglected epidemic. WHO has declared road traffic accidents (RTA) as the number one cause of death among those aged 15-29 years. India has witnessed 31.3% of the road traffic deaths among 15 to 29 years individuals in the year 2011 as reported by national crime records bureau. This study is aimed to learn and study risk perception and practice of road safety measures among medical students. Methods: A Cross-sectional study was conducted among medical students with an objective A 297 M.B.B.S. students were selected by convenient sampling technique. The study period was May-August, 2016. The information collected was analysed using SPSS version 16 & Microsoft excels 2007 software. Results: Majority of boys (82% and 98%) and girls (55% & 66%) had a satisfactory understanding of traffic rules and traffic signs & signals, respectively. While exploring on the helmet use, only 36% of girls were aware of its importance. About the factors responsible for the crash severity, participants showed a lesser concern to the seat-belts & child restraints (59% boys and 39% girls). Notably only 52% of male participants were in view that alcohol consumption sometimes increases the severity while driving. Conclusions: Abidance to road safety was not found satisfactory. Adequate interventions and reorientation training towards road safety need to be introduced among young drivers.


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Prevalence of intestinal parasites and its associated socio-demographic factors among the food handlers of Bagalkot city, Karnataka, India

2016-11-29T04-51-50Z
Source: International Journal of Community Medicine and Public Health
Waseem Anjum, Pavan S. Kalasker, Kurre Bhaskar.
Background: Growing urbanization and lifestyle changes lead people to dine away from home more often, contributing to the unregulated opening of eating establishments that often have inadequate hygiene conditions. Hence a study was undertaken to know prevalence and determinants of intestinal parasitic infections among food handlers of Bagalkot city, Karnataka, India. Methods: A cross-sectional study was done among food handlers of 46 food establishments enlisted in Bagalkot hotel and refreshment association. A total of 266 food handlers were interviewed using proforma regarding socio-demographic data and personal hygiene followed by stool examination for intestinal parasites. Results: Out of 266 food handlers, 39 (14.7%) were tested positive for intestinal parasitic infections. Most common parasite isolated was A. Lumbricoides (5.3%) followed by E. Histolytica (1.5%), Giardia (1.5%), T. Solium (0.8%), T. Trichura (0.8%) and H. Nana (0.8%). Mixed infections constituted 4.1%.Female gender, rural residence and socio-economic status and personal hygiene was significantly associated with intestinal parasitic infections. Conclusions: Strict hygienic practices, complete treatment of infected persons and regular surveillance is important for controlling intestinal parasitic infections.


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Cognitive Training in Parkinsons Disease: A Theoretical Perspective

Cognitive impairment is now widely accepted as a fundamental aspect of Parkinson's disease (PD). Given the prevalence of cognitive impairment and the associated impact on well-being, evidence-based interventions are needed. However, while research is continually accumulating in order to better understand the pathology and trajectory of cognitive changes, treatment options lag behind. Nonpharmacological approaches are of particular interest in this group, given the typical polypharmacy already present in PD patients. In this regard, cognitive training (CT) is a relatively new and prominent therapeutic option with accumulating scientific support and increasing public awareness. Research has now established benefits across many different populations, and trials investigating the use of CT specifically in PD are becoming more common. We offer a brief summary of CT and its efficacy in PD samples to date, as well as discuss areas requiring further exploration in this group. Crucially, we suggest that CT should be supported as a research priority in PD, given both proven and potential benefits as a noninvasive and well-tolerated behavioral intervention for cognitive impairment.



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How and why are calcium currents curtailed in the skeletal muscle voltage-gated calcium channels?

Voltage-gated calcium channels represent the sole mechanism converting electrical signals of excitable cells into cellular functions such as contraction, secretion, and gene regulation. Specific voltage-sensing domains detect changes in membrane potentials and control channel gating. Calcium ions entering through the channel function as second messengers regulating cell functions; with the exception of skeletal muscle, where CaV1.1 is essentially not functioning as channel but activates calcium release from intracellular stores. It has long been known that calcium currents are dispensable for skeletal muscle contraction. However, the questions as to how and why the channel function of CaV1.1 is curtailed remained obscure until the recent discovery of a developmental CaV1.1 splice variant with normal channel functions. This discovery enabled new means to study the molecular mechanisms regulating the channel gating and led to the understanding that in skeletal muscle calcium currents need to be restricted to allow proper regulation of fibre type specification and to prevent mitochondrial damage.

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A retrospective review of anesthesia and perioperative care in children with medium-chain acyl-CoA dehydrogenase deficiency

Summary

Background

Medium-chain acyl-CoA dehydrogenase deficiency is the most common genetically determined disorder of mitochondrial fatty acid oxidation. Decompensation can result in hypoglycemia, seizures, coma, and death but may be prevented by ensuring glycogen stores do not become depleted. Perioperative care is of interest as surgery, fasting, and infection may all trigger decompensation and the safety of anesthetic agents has been questioned. Current guidelines from the British Inherited Metabolic Disease Group advise on administering fluid containing 10% glucose during the perioperative period.

Aim

To review the management of anesthesia and perioperative care for children with medium-chain acyl-CoA dehydrogenase deficiency and determine the frequency and nature of any complications.

Method

A retrospective review of case notes of children with medium-chain acyl-CoA dehydrogenase deficiency undergoing anesthesia between 1997 and 2014.

Results

Fourteen patients underwent 21 episodes of anesthesia. In 20 episodes, the patient received a glucose-containing fluid during their perioperative fast, of which eight received fluid containing 10% dextrose throughout the entire perioperative period. No episodes of hypoglycemia or decompensation occurred, but perioperative hyperglycemia occurred in five episodes. A propofol bolus was administered at induction in 16 episodes and volatile agents were administered for maintenance of anesthesia in all episodes without any observed complications. In one episode, delayed offset of atracurium was reported.

Conclusions

Perioperative metabolic decompensation and hypoglycemia appear to be uncommon in children who are well and receive glucose supplementation. Hyperglycemia may occur as a consequence of surgery and glucose supplementation. Propofol boluses and volatile anesthetic agents were used without any apparent complications. Prolonged action of atracurium was reported in one case, suggesting that nondepolarizing muscle relaxants may have delayed offset in this patient group. We do not recommend any particular approach to anesthesia but would advise administering glucose supplementation according to current guidelines, frequent monitoring of blood glucose perioperatively, and monitoring of neuromuscular blockade.

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The timing and prevalence of intraoperative hypotension in infants undergoing laparoscopic pyloromyotomy at a tertiary pediatric hospital

Summary

Background

Intraoperative hypotension may be associated with adverse outcomes in children undergoing surgery. Infants and neonates under 6 months of age have less autoregulatory cerebral reserve than older infants, yet little information exists regarding when and how often intraoperative hypotension occurs in infants.

Aims

To better understand the epidemiology of intraoperative hypotension in infants, we aimed to determine the prevalence of intraoperative hypotension in a generally uniform population of infants undergoing laparoscopic pyloromyotomy.

Methods

Vital sign data from electronic records of infants who underwent laparoscopic pyloromyotomy with general anesthesia at a children's hospital between January 1, 1998 and October 4, 2013 were analyzed. Baseline blood pressure (BP) values and intraoperative BPs were identified during eight perioperative stages based on anesthesia event timestamps. We determined the occurrence of relative (systolic BP <20% below baseline) and absolute (mean arterial BP <35 mmHg) intraoperative hypotension within each stage.

Results

A total of 735 full-term infants and 82 preterm infants met the study criteria. Relative intraoperative hypotension occurred in 77%, 72%, and 58% of infants in the 1–30, 31–60, and 61–90 days age groups, respectively. Absolute intraoperative hypotension was seen in 21%, 12%, and 4% of infants in the 1–30, 31–60, and 61–90 days age groups, respectively. Intraoperative hypotension occurred primarily during surgical prep and throughout the surgical procedure. Preterm infants had higher rates of absolute intraoperative hypotension than full-term infants.

Conclusions

Relative intraoperative hypotension was routine and absolute intraoperative hypotension was common in neonates and infants under 91 days of age. Preterm infants and infants under 61 days of age experienced the highest rates of absolute and relative intraoperative hypotension, particularly during surgical prep and throughout surgery.

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Phenotypic and Genotypic Resistance of Salmonella Isolates from Healthy and Diseased Pigs in China During 2008–2015

Microbial Drug Resistance , Vol. 0, No. 0.


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