Whole-Genome Sequence Analysis of CTX-M Containing Escherichia coli Isolates from Retail Meats and Cattle in the United States

Microbial Drug Resistance, Ahead of Print.


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Mapping and Sequencing of a Significant Quantitative Trait Locus Affecting Resistance to Koi Herpesvirus in Common Carp

Cyprinids are the most highly produced group of fishes globally, with common carp being one of the most valuable species of the group. Koi herpesvirus (KHV) infections can result in high levels of mortality, causing major economic losses, and is listed as a notifiable disease by the World Organisation for Animal Health. Selective breeding for host resistance has the potential to reduce morbidity and losses due to KHV. Therefore, improving knowledge about host resistance and methods of incorporating genomic data into breeding for resistance may contribute to a decrease in economic losses in carp farming. In the current study, a population of 1,425 carp juveniles, originating from a factorial cross between 40 sires and 20 dams was challenged with KHV. Mortalities and survivors were recorded and sampled for genotyping by sequencing using Restriction Site-Associated DNA sequencing (RADseq). Genome-wide association analyses were performed to investigate the genetic architecture of resistance to KHV. A genome-wide significant QTL affecting resistance to KHV was identified on linkage group 44, explaining approximately 7 % of the additive genetic variance. Pooled whole genome resequencing of a subset of resistant (n = 60) and susceptible animals (n = 60) was performed to characterize QTL regions, including identification of putative candidate genes and functional annotation of associated polymorphisms. The TRIM25 gene was identified as a promising positional and functional candidate within the QTL region of LG 44, and a putative premature stop mutation in this gene was discovered.

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MiR-139-5p regulates VEGFR and downstream signaling pathways to inhibit the development of esophageal cancer

MiR-139-5p plays a significant role in tumorigenesis, metastasis and recurrence, suggesting that it may potentially be used as a promising biomarker for esophageal cancer diagnosis, prognosis and therapy. This study aimed to investigate the role and the mechanism of miRNA-139-5p in esophageal cancer.

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MiR-139-5p regulates VEGFR and downstream signaling pathways to inhibit the development of esophageal cancer

MiR-139-5p plays a significant role in tumorigenesis, metastasis and recurrence, suggesting that it may potentially be used as a promising biomarker for esophageal cancer diagnosis, prognosis and therapy. This study aimed to investigate the role and the mechanism of miRNA-139-5p in esophageal cancer.

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5 critical thinking skills crucial to EMS professional development

Continuous skills development is the key for emergency responders staying current in a changing world

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Haptic exploration attenuates and alters somatosensory cortical oscillations

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


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Glutamatergic neurons of the paraventricular nucleus are critical contributors to the development of neurogenic hypertension

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


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Nitric oxide dependent attenuation of norepinephrine‐induced vasoconstriction is impaired in the canine model of Duchenne muscular dystrophy

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


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A Cost-Effectiveness Analysis Of A Randomized Control Trial Of A Tailored, Multifactorial Program To Prevent Falls Among The Community-Dwelling Elderly

Publication date: Available online 27 August 2018

Source: Archives of Physical Medicine and Rehabilitation

Author(s): David B. Matchar, Kirsten Eom, Pamela W. Duncan, Mina Lee, Rita Sim, Nirmali R. Sivapragasam, Christopher T. Lien, Marcus Eng Hock Ong

Abstract

Objective

To perform a cost-effectiveness analysis of a multifactorial, tailored intervention to reduce falls among a heterogeneous group of high-risk elderly.

Design

Randomized control trial

Settings

Communities

Participants

Adults aged at least 65 years (N=354) seen at the ED for a fall or fall-related injury and discharged home.

Interventions

The intervention group received a tailored program of physical therapy focused on progressive training in strength, balance, and gait for a period of 3 months. They also received screening and referrals for low vision, polypharmacy, and environmental hazards. The Short Physical Performance Battery (SPPB) test was assessed at regular intervals to allocate participants into either a home-based or group centre-based program. The control group received usual care prescribed by a physician and educational materials on falls prevention.

Main outcome measures

The incremental cost-effectiveness ratio (ICER) over the 9-month study period based on intervention costs and utility in terms of quality-adjusted life years (QALYs) calculated from EuroQol-5D scores.

Results

The ICER was S$ 120, 667 per QALY gained (S$ 362 / 0.003 QALYs), above benchmark values (S$ 70,000). However, the intervention was more effective and cost-saving among those with SPPB scores of greater than 6 at baseline, higher cognitive function, better vision and no more than 1 fall in the preceding 6 months. The intervention was also cost-effective among those with 0-1 critical comorbidities ($ 22, 646 / QALY).

Conclusion

The intervention was, overall, not cost-effective, compared to usual care. However, the program was cost-effective among healthier subgroups, and even potentially cost-saving among individuals with sufficient reserve to benefit.

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Systematic review with meta-analysis: The prevalence of coeliac disease in patients with osteoporosis

Alimentary Pharmacology and Therapeutics

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Serum angiopoietin-2 predicts mortality and kidney outcomes in decompensated cirrhosis

Hepatology

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Association of non-alcoholic fatty liver disease with thyroid function: A systematic review and meta-analysis

Digestive and Liver Diseases

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Efficacy of secretagogues in patients with irritable bowel syndrome with constipation: Systematic review and network meta-analysis

Gastroenterology

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Risk factors for post-ERCP cholecystitis: A single-center retrospective study

BMC Gastroenterology

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Risk of hepatocellular cancer in patients with non-alcoholic fatty liver disease

Gastroenterology

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Effects of long-term norfloxacin therapy in patients with advanced cirrhosis

Gastroenterology

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Liver disease and mortality among patients with hip fracture: A population-based cohort study

Clinical Epidemiology

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Multilineage ACTB mutation in a patient with fibro‐osseous maxillary lesion and pilocytic astrocytoma

American Journal of Medical Genetics Part A, EarlyView.


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Phenotypic diversity of patients diagnosed with VACTERL association

American Journal of Medical Genetics Part A, EarlyView.


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Novel compound heterozygous EPG5 mutations consisted with a missense mutation and a microduplication in the exon 1 region identified in a Japanese patient with Vici syndrome

American Journal of Medical Genetics Part A, EarlyView.


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Development of body proportions in achondroplasia: Sitting height, leg length, arm span, and foot length

American Journal of Medical Genetics Part A, EarlyView.


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Isolated dentinogenesis imperfecta with glass‐like enamel caused by COL1A2 mutation

American Journal of Medical Genetics Part A, EarlyView.


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Intrafamilial clinical variability in four families with incontinentia pigmenti

American Journal of Medical Genetics Part A, EarlyView.


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De novo variant in KIF26B is associated with pontocerebellar hypoplasia with infantile spinal muscular atrophy

American Journal of Medical Genetics Part A, EarlyView.


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Clinical courses of children with trisomy 13 receiving intensive neonatal and pediatric treatment

American Journal of Medical Genetics Part A, EarlyView.


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Variable Clinical Manifestations of Xia‐Gibbs syndrome: Findings of Consecutively Identified Cases at a Single Children's Hospital

American Journal of Medical Genetics Part A, EarlyView.


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Silver Russel syndrome in an aboriginal patient from Australia

American Journal of Medical Genetics Part A, EarlyView.


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Office-based surgery and patient outcomes

Purpose of review The purpose of this review is to provide an update on the current knowledge about patient safety and outcomes in the office-based setting. Ambulatory procedures performed outside the hospital are steadily increasing, resulting in an increasing number and complexity of office-based procedures and patient comorbidities over the past two decades. In this review we focus on most recent outcomes studies encompassing different surgical specialties and patient populations. Recent findings Rates of complications in the office-based surgical (OBS) setting from the latest publications are similar to, or better than previously reported studies. Many of the studies published were in the field of plastic surgery, with a few publications on office vascular and dental procedures. The most common complications were haematomas, infections and venous thromboembolisms (VTE)s and pulmonary emboli. Death was a rare finding, though when it occurred, it was often associated with VTE/pulmonary emboli and abdominoplasties. Summary Overall, these studies contribute positively to the safety of office-based anaesthesia. As an increasing number of procedures migrate from the hospital setting to ambulatory and office-based environments, it will be critically important to continue ensuring patients are well tolerated. Correspondence to Richard D. Urman, MD, MBA, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Tel: +1 617 732 8222; e-mail: Rurman@bwh.harvard.edu Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.

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Differential targeting and signaling of voltage‐gated T‐type Cav3.2 and L‐type Cav1.2 channels to ryanodine receptors in mesenteric arteries

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


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A Multicenter Study to Evaluate Pulmonary Function in Osteogenesis Imperfecta

Clinical Genetics, Volume 0, Issue ja, -Not available-.


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