Τρίτη 10 Μαΐου 2016

Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons

Ca2+-activated potassium currents [IK(Ca)] are an important link between the intracellular signaling system and the membrane potential, which shapes intrinsic electrophysiological properties. To better understand the ionic mechanisms that mediate intrinsic firing properties of olfactory uniglomerular projection neurons (uPNs), we used whole cell patch-clamp recordings in an intact adult brain preparation of the male cockroach Periplaneta americana to analyze IK(Ca). In the insect brain, uPNs form the principal pathway from the antennal lobe to the protocerebrum, where centers for multimodal sensory processing and learning are located. In uPNs the activation of IK(Ca) was clearly voltage and Ca2+ dependent. Thus under physiological conditions IK(Ca) is strongly dependent on Ca2+ influx kinetics and on the membrane potential. The biophysical characterization suggests that IK(Ca) is generated by big-conductance (BK) channels. A small-conductance (SK) channel-generated current could not be detected. IK(Ca) was sensitive to charybdotoxin (CTX) and iberiotoxin (IbTX) but not to apamin. The functional role of IK(Ca) was analyzed in occlusion experiments under current clamp, in which portions of IK(Ca) were blocked by CTX or IbTX. Blockade of IK(Ca) showed that IK(Ca) contributes significantly to intrinsic electrophysiological properties such as the action potential waveform and membrane excitability.



from Physiology via xlomafota13 on Inoreader http://ift.tt/1T561V8
via IFTTT

Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex

The action potential (AP) is a fundamental feature of excitable cells that serves as the basis for long-distance signaling in the nervous system. There is considerable diversity in the appearance of APs and the underlying repolarization mechanisms in different neuronal types (reviewed in Bean BP. Nat Rev Neurosci 8: 451–465, 2007), including among pyramidal cell subtypes. In the present work, we used specific pharmacological blockers to test for contributions of Kv1, Kv2, or Kv4 channels to repolarization of single APs in two genetically defined subpopulations of pyramidal cells in layer 5 of mouse somatosensory cortex (etv1 and glt) as well as pyramidal cells from layer 2/3. These three subtypes differ in AP properties (Groh A, Meyer HS, Schmidt EF, Heintz N, Sakmann B, Krieger P. Cereb Cortex 20: 826–836, 2010; Guan D, Armstrong WE, Foehring RC. J Neurophysiol 113: 2014–2032, 2015) as well as laminar position, morphology, and projection targets. We asked what the roles of Kv1, Kv2, and Kv4 channels are in AP repolarization and whether the underlying mechanisms are pyramidal cell subtype dependent. We found that Kv4 channels are critically involved in repolarizing neocortical pyramidal cells. There are also pyramidal cell subtype-specific differences in the role for Kv1 channels. Only Kv4 channels were involved in repolarizing the narrow APs of glt cells. In contrast, in etv1 cells and layer 2/3 cells, the broader APs are partially repolarized by Kv1 channels in addition to Kv4 channels. Consistent with their activation in the subthreshold range, Kv1 channels also regulate AP voltage threshold in all pyramidal cell subtypes.



from Physiology via xlomafota13 on Inoreader http://ift.tt/1WnmU32
via IFTTT

Blocking trial-by-trial error correction does not interfere with motor learning in human walking

Movements can be learned implicitly in response to new environmental demands or explicitly through instruction and strategy. The former is often studied in an environment that perturbs movement so that people learn to correct the errors and store a new motor pattern. Here, we demonstrate in human walking that implicit learning of foot placement occurs even when an explicit strategy is used to block changes in foot placement during the learning process. We studied people learning a new walking pattern on a split-belt treadmill with and without an explicit strategy through instruction on where to step. When there is no instruction, subjects implicitly learn to place one foot in front of the other to minimize step-length asymmetry during split-belt walking, and the learned pattern is maintained when the belts are returned to the same speed, i.e., postlearning. When instruction is provided, we block expression of the new foot-placement pattern that would otherwise naturally develop from adaptation. Despite this appearance of no learning in foot placement, subjects show similar postlearning effects as those who were not given any instruction. Thus locomotor adaptation is not dependent on a change in action during learning but instead can be driven entirely by an unexpressed internal recalibration of the desired movement.



from Physiology via xlomafota13 on Inoreader http://ift.tt/1T561V0
via IFTTT

An asymmetric outer retinal response to drifting sawtooth gratings

Electroretinogram (ERG) studies have demonstrated that the retinal response to temporally modulated fast-ON and fast-OFF sawtooth flicker is asymmetric. The response to spatiotemporal sawtooth stimuli has not yet been investigated. Perceptually, such drifting gratings or diamond plaids shaded in a sawtooth pattern appear brighter when movement produces fast-OFF relative to fast-ON luminance profiles. The neural origins of this illusion remain unclear (although a retinal basis has been suggested). Thus we presented toad eyecups with sequential epochs of sawtooth, sine-wave, and square-wave gratings drifting horizontally across the retina at temporal frequencies of 2.5–20 Hz. All ERGs revealed a sustained direct-current (DC) transtissue potential during drift and a peak at drift offset. The amplitudes of both phenomena increased with temporal frequency. Consistent with the human perceptual experience of sawtooth gratings, the sustained DC potential effect was greater for fast-OFF cf. fast-ON sawtooth. Modeling suggested that the dependence of temporal luminance contrast on stimulus device frame rate contributed to the temporal frequency effects but could not explain the divergence in response amplitudes for the two sawtooth profiles. The difference between fast-ON and fast-OFF sawtooth profiles also remained following pharmacological suppression of postreceptoral activity with tetrodotoxin (TTX), 2-amino-4-phosphonobutric acid (APB), and 2,3 cis-piperidine dicarboxylic acid (PDA). Our results indicate that the DC potential difference originates from asymmetries in the photoreceptoral response to fast-ON and fast-OFF sawtooth profiles, thus pointing to an outer retinal origin for the motion-induced drifting sawtooth brightness illusion.



from Physiology via xlomafota13 on Inoreader http://ift.tt/1WnmTMo
via IFTTT

A Cadaveric Study Assessing the Accuracy of Ultrasound Guided Sacroiliac Joint Injections

Ultrasound guidance has been proposed as an alternate imaging modality for sacroiliac (SI) joint injections. Few studies have been published on the accuracy of this modality for the procedure.

from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1sbDhnh
via IFTTT

Franklin Delano Roosevelt: the Diagnosis of Poliomyelitis Revisited

Revisiting the ailments of famous historical persons in light of contemporary medical understanding has become a common academic hobby. Public discussion of Franklin Delano Roosevelt's (FDR) diagnosis of poliomyelitis following his sudden onset of paralysis in 1921 has received just such a revisitation. Recently, this 2003 historical analysis has been widely referenced on the Internet and in biographies raising speculation that his actual diagnosis should have been Guillain-Barre Syndrome, a non-contagious disease of the peripheral nervous system rather than poliomyelitis.

from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1ZCXUTA
via IFTTT

Implementation of Actigraphy in Acute Traumatic Brain Injury Neurorehabilitation Admissions: A Veterans Administration TBI Model Systems Feasibility Study

Sleep problems and disorders are prevalent in TBI and are associated with negative outcomes. Incidence varies due to challenges including differences in assessment methods particularly in acute stages of recovery when patients are cognitively impaired and unable to complete traditional self-report methods. Actigraphy (ACG) has recently been validated in the acute TBI rehabilitation setting and may serve as a superior method of assessing sleep-wake patterns at this stage of recovery. Although a few studies with small sample sizes have described using ACG, none have described feasibility and implementation protocols.

from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1sbDh6V
via IFTTT

Acute and Long-Term Effects of Multidirectional Treadmill Training on Gait and Balance in Parkinson's Disease

Treadmill training has been shown to be a promising rehabilitation strategy for improving gait and balance in persons with Parkinson's disease (PD). Most studies have involved only forward walking as an intervention. The effects of multidirectional treadmill (forward, backward, and left and right sideways) on gait and balance have not been reported.

from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1ZCXUTu
via IFTTT

The Origin of the Abnormal Muscle Response Seen in Hemifacial Spasm Remains Controversial

We read with interest the manuscript by Kameyama et al. (2016) entitled "Ephaptic Transmission is the origin of the abnormal muscle response seen in hemifacial spasm". The authors describe an elegant electrophysiological study designed to elucidate the pathophysiological mechanisms underlying this condition. Their conclusions are in support of the peripheral theory of ephaptic transmission. Following a careful review of their interpretation of results and conclusions, we respectfully suggest the central theory of abnormal hyper-excitability of the facial nucleus remains a more likely cause of hemifacial spasm.

from Physiology via xlomafota13 on Inoreader http://ift.tt/1XkbCfE
via IFTTT

Effect of Muscle Length on Fatigue Induced by Low Frequency Current Stimulation in Human Medial Gastrocnemius Muscle

2016-05-10T16-43-04Z
Source: International Journal of Therapies and Rehabilitation Research
Tarek Mohamed El Gohary, Sameh Refaat Ibrahim, Waleed Salah Elddin Mahmoud, Hatem Ahmed Emara, Mostafa Saber Ahmed.
Abstract: Background: Muscle force is affected by many factors including muscle length. The exact mechanism of the effect of muscle length is not fully understood. Objective: to determine if motoneuron discharges accommodate changes imposed by changing Medial gastrocnemius muscle length following electrically fatiguing protocol. Methods: Randomized clinical trial was conducted on 60 untrained subjects aged (20-40 years) in isokinetic & electromyography lab of Faculty of Physical Therapy in august 2014. Both fatiguing short length group (FS) and fatiguing long length group (FL) underwent low frequency electrically fatiguing protocol. Main Outcome Measures: Outcome measures obtained pre and post the fatiguing protocol were the compound muscle action potential. Results: there were no significant difference between pre outcome measures in both groups (p= 0.837) and post outcome measures in both groups (p= 0.119). Significant main effects of fatigue were observed in both groups (p= 0.0001). Significant main effects of muscle length were observed between post measurements of fatiguing short length group and post measurement of fatiguing long length group. Conclusion: Fatigue has been shown to be greater at long muscle lengths than at short muscle lengths following low frequency current fatiguing protocol.


from Scope via xlomafota13 on Inoreader http://ift.tt/21UlM6W
via IFTTT

Experimental type II diabetes and related models of impaired glucose metabolism differentially regulate glucose transporters at the proximal tubule brush border membrane

New Findings

  • What is the central question of this study?

    Although SGLT2 inhibitors represent a promising treatment for patients suffering from diabetic nephropathy, the influence of metabolic disruption on the expression and function of glucose transporters is largely unknown.

  • What is the main finding and its importance?

    In vivo models of metabolic disruption (Goto–Kakizaki type II diabetic rat and junk-food diet) demonstrate increased expression of SGLT1, SGLT2 and GLUT2 in the proximal tubule brush border. In the type II diabetic model, this is accompanied by increased SGLT- and GLUT-mediated glucose uptake. A fasted model of metabolic disruption (high-fat diet) demonstrated increased GLUT2 expression only. The differential alterations of glucose transporters in response to varying metabolic stress offer insight into the therapeutic value of inhibitors.

SGLT2 inhibitors are now in clinical use to reduce hyperglycaemia in type II diabetes. However, renal glucose reabsorption across the brush border membrane (BBM) is not completely understood in diabetes. Increased consumption of a Western diet is strongly linked to type II diabetes. This study aimed to investigate the adaptations that occur in renal glucose transporters in response to experimental models of diet-induced insulin resistance. The study used Goto–Kakizaki type II diabetic rats and normal rats rendered insulin resistant using junk-food or high-fat diets. Levels of protein kinase C-βI (PKC-βI), GLUT2, SGLT1 and SGLT2 were determined by Western blotting of purified renal BBM. GLUT- and SGLT-mediated d-[3H]glucose uptake by BBM vesicles was measured in the presence and absence of the SGLT inhibitor phlorizin. GLUT- and SGLT-mediated glucose transport was elevated in type II diabetic rats, accompanied by increased expression of GLUT2, its upstream regulator PKC-βI and SGLT1 protein. Junk-food and high-fat diet feeding also caused higher membrane expression of GLUT2 and its upstream regulator PKC-βI. However, the junk-food diet also increased SGLT1 and SGLT2 levels at the proximal tubule BBM. Glucose reabsorption across the proximal tubule BBM, via GLUT2, SGLT1 and SGLT2, is not solely dependent on glycaemic status, but is also influenced by diet-induced changes in glucose metabolism. We conclude that different metabolic disturbances result in complex adaptations in renal glucose transporter protein levels and function.

Thumbnail image of graphical abstract

from Physiology via xlomafota13 on Inoreader http://ift.tt/1UR1o5R
via IFTTT

Clinical settings of arterial catheter's insertion with new infrared device “MillSuss”

A continuous arterial line is an effective monitor for patients with severe complication such as aortic stenosis and internal carotid artery stenosis because we can measure constant monitoring and recording of the patient's blood pressure [1]. In particular, the insertion of radial artery is selected for safety and convenience [2]. MillSuss (Covidien, Tokyo, Japan; Fig. 1) is a newly developed wrist vascular visualize device with near infrared light. MillSuss can easily visualize a blood stream.

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1rSC1EY
via IFTTT

Magnesium sulfate or diltiazem as adjuvants to total intravenous anesthesia to reduce blood loss in functional endoscopic sinus surgery

gr1.sml

This study was designed to know whether addition of magnesium sulfate (MgSO4) or diltiazem to total intravenous anesthesia (TIVA) (propofol) aided reduction in blood loss during functional endoscopic sinus surgery (FESS). The secondary outcomes measured were surgeon's assessment of the surgical field and hemodynamics.

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1Xk6zvq
via IFTTT

Video-assisted thoracoscopic surgery in an adult moyamoya disease case

gr1.sml

Moyamoya disease (MMD) is a progressive cerebrovascular occlusive disease of the internal carotid arteries and their proximal branches with compensatory collateral networks and is an increasingly recognized cause of stroke [1]. During the perioperative period, appropriate hemodynamic control and ventilation are required to prevent cerebral ischemia in patients with MMD [2]. There are some reports of cardiac surgery in MMD patients [3,4]; however, lung surgery, which is also challenging for these patients because one-lung ventilation (OLV) additionally complicates respiratory management, has never been reported.

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1Xk6x6Y
via IFTTT

Clinical experiences of laser Doppler blood flow sensor for thoracic paravertebral nerve block

A thoracic paravertebral nerve block (TPVB) is a technique where a bolus of local anesthetic is injected in the paravertebral space and can block ipsilateral somatic and sympathetic nerve blocks [1]. That is to say, we can confirm the increase of blood flow if the procedure of TPVB is successful. A laser Doppler flow sensor can measure a peripheral blood flow in the living by applying the optical disc technology. However, we cannot sometimes measure the peripheral blood flow exactly because of noise.

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1Xk6zf5
via IFTTT

Rocuronium is associated with an increased risk of reintubation in patients with soft tissue infections

gr1.sml

To determine risk factors associated with reintubations in adult patients with soft tissue infections.

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1rSC17K
via IFTTT

PED Asthma TX



from EMS via xlomafota13 on Inoreader http://ift.tt/1OlThHN
via IFTTT

What Would You Do? A co-worker despises, calls EMS patients derogatory names

Dr. David Tan and paramedic Steve Whitehead discuss a complex scenario regarding paramedics who despise certain patients and use derogatory terms to refer to those patients. The discussion covers symptoms of burnout and recognizing that EMS serves and cares for others. After watching the discussion share your thoughts on this scenario in the comments and read this article about recognizing and treating your own burnout.

from EMS via xlomafota13 on Inoreader http://ift.tt/1WnaU2a
via IFTTT

Remember 2 Things: Altered mental status in geriatric patients

EMS providers frequently assess geriatric patients with altered mental status. This EMS1 training video reviews two common conditions - hypoglycemia and sepsis - that can cause changes in a patient's mental status. After watching Steve Whitehead discuss these conditions learn more about sepsis assessment and treatment in articles from Kelly Grayson (How capnography can be used to identify sepsis) and Rom Duckworth (Sepsis 3.0: implications for paramedics and prehospital care). Then share your geriatric assessment tips in the comments.

from EMS via xlomafota13 on Inoreader http://ift.tt/1OlGNzD
via IFTTT

Remember 2 Things: Stroke mimics

Several conditions mimic or look like stroke. Remember the two things - hypogylcemia and seizures - that can often look like stroke in this EMS1 training video from Steve Whitehead. After watching share your experience with stroke scales in the comments, watch another episode of Remember 2 Things on improving stroke recognition and response, and read more about stroke assessment scales.

from EMS via xlomafota13 on Inoreader http://ift.tt/1OlDqZG
via IFTTT

What Would You Do? A co-worker despises, calls EMS patients derogatory names

Dr. David Tan and paramedic Steve Whitehead discuss a complex scenario regarding paramedics who despise certain patients and use derogatory terms to refer to those patients. The discussion covers symptoms of burnout and recognizing that EMS serves and cares for others. After watching the discussion share your thoughts on this scenario in the comments and read this article about recognizing and treating your own burnout.

from EMS via xlomafota13 on Inoreader http://ift.tt/1WnaU2a
via IFTTT

Remember 2 Things: Altered mental status in geriatric patients

EMS providers frequently assess geriatric patients with altered mental status. This EMS1 training video reviews two common conditions - hypoglycemia and sepsis - that can cause changes in a patient's mental status. After watching Steve Whitehead discuss these conditions learn more about sepsis assessment and treatment in articles from Kelly Grayson (How capnography can be used to identify sepsis) and Rom Duckworth (Sepsis 3.0: implications for paramedics and prehospital care). Then share your geriatric assessment tips in the comments.

from EMS via xlomafota13 on Inoreader http://ift.tt/1OlGNzD
via IFTTT

Remember 2 Things: Stroke mimics

Several conditions mimic or look like stroke. Remember the two things - hypogylcemia and seizures - that can often look like stroke in this EMS1 training video from Steve Whitehead. After watching share your experience with stroke scales in the comments, watch another episode of Remember 2 Things on improving stroke recognition and response, and read more about stroke assessment scales.

from EMS via xlomafota13 on Inoreader http://ift.tt/1OlDqZG
via IFTTT

The EMS calls that make me sad, frustrated and vulnerable

By Susie Crosby

We had a difficult call today. You know I can't go into details, but I can tell you that it wasn't easy and it hit me hard.

Being part of an ambulance crew can put some pretty unpleasant things into view. I've seen trauma ... "blood n' guts" ... and death.

I've honestly been surprised by my whole reaction to it all ... or lack of reaction. Sometimes it actually bothers me that I'm not bothered by it more.

While I do have a rather strong stomach and I am a bit of a trauma/training junkie I just chalked it up to a sort of disconnect for the purpose of self-preservation. It's an ability to do my job in controlled chaos.

Sometimes the hardest calls aren't the ones we might think. One particular call that stuck with me didn't end in death and didn't involve any gore. But it was an event that would change a young life forever. It's the one I think about that tears at my heart the most.

So I've come to the conclusion that it's the human element that gets me. It's doing everything I can, bringing all the different aspects of my training together, performing to the best of my ability and I still can't direct the outcome.

Those calls make me sad. They frustrate me and they make me feel vulnerable.

My first response isn't to walk away feeling proud that I've done all I could. It's to walk away thinking of any possible way I could have done better.

While it's not a warm and fuzzy feeling, it is a necessary feeling, and one that hopefully will benefit the next patient and make the next call go more smoothly.

I believe the Good Lord makes the ultimate decision as to which patient makes it and which doesn't. He also gives us the skills and the privilege to make the process a little easier.

About the author
Susie George is an EMT-Intermediate in rural Oregon, mother of seven and lives on a small hobby farm. 



from EMS via xlomafota13 on Inoreader http://ift.tt/23ELeN0
via IFTTT

EMS Artwork: Calm torment

We recently worked a cardiac arrest where a woman collapsed while enjoying a dinner her husband of 50 years prepared for her. When we arrived, he was doing CPR on her in the middle of the kitchen floor while following the instructions given to him on the phone by the dispatcher. Other family members were in the living room in a state of unbelief and worry, they greeted us with such relief. People seem to think when we arrive we're going to save the day and everything will be OK.

Read more about this image here.

Dan Sun Photos Routine



from EMS via xlomafota13 on Inoreader http://ift.tt/1WneaKO
via IFTTT

What Would You Do? A co-worker despises, calls EMS patients derogatory names

Dr. David Tan and paramedic Steve Whitehead discuss a complex scenario regarding paramedics who despise certain patients and use derogatory terms to refer to those patients. The discussion covers symptoms of burnout and recognizing that EMS serves and cares for others. After watching the discussion share your thoughts on this scenario in the comments and read this article about recognizing and treating your own burnout.

from EMS via xlomafota13 on Inoreader http://ift.tt/1WnaU2a
via IFTTT

Remember 2 Things: Altered mental status in geriatric patients

EMS providers frequently assess geriatric patients with altered mental status. This EMS1 training video reviews two common conditions - hypoglycemia and sepsis - that can cause changes in a patient's mental status. After watching Steve Whitehead discuss these conditions learn more about sepsis assessment and treatment in articles from Kelly Grayson (How capnography can be used to identify sepsis) and Rom Duckworth (Sepsis 3.0: implications for paramedics and prehospital care). Then share your geriatric assessment tips in the comments.

from EMS via xlomafota13 on Inoreader http://ift.tt/1OlGNzD
via IFTTT

Remember 2 Things: Stroke mimics

Several conditions mimic or look like stroke. Remember the two things - hypogylcemia and seizures - that can often look like stroke in this EMS1 training video from Steve Whitehead. After watching share your experience with stroke scales in the comments, watch another episode of Remember 2 Things on improving stroke recognition and response, and read more about stroke assessment scales.

from EMS via xlomafota13 on Inoreader http://ift.tt/1OlDqZG
via IFTTT

5 questions EMS leaders need to answer for city and county officials

By Bruce Moeller, Ph.D.

Most city and county officials have never had the opportunity — or thrill — of responding lights and sirens to a resident's home in order to provide lifesaving medical care.

And while that imagery can serve as a powerful argument for unwavering support and funding of your EMS program, municipal leaders, both elected and appointed, have many competing priorities and need to make themselves more knowledgeable of current and emerging issues in the delivery of EMS — and what they can do to ensure the community's EMS needs are being met.

EMS leaders also need to play a role in educating city and county administrators so they are making informed decisions about EMS service. Here is a series of five questions that EMS leaders should explore with their local officials to improve their understanding of this vital service and effectively manage the community's expectations for emergency medical care.

1. What are your community's expectations for EMS services"
This is a difficult question to answer, for the city manager, EMS chief or even the public. A community's expectations for EMS services are often vague — residents want fast and effective EMS, but don't always know what that means.

The first issue is typically the level of service to provide — basic life support or advanced life support. While the ALS level has historically been the gold standard of care, there continue to be well-researched medical studies suggesting that ALS care makes a significant difference for only a small number of patients.

You will likely find that citizen expectations will often match the level of service they have received historically. So while you can always upgrade from BLS to ALS, it is extremely difficult to reduce back down to a lower level of care, even in cases when it might be as effective and more efficient to do so.

Response time has historically been the one measure of system performance most measured and talked about — and the most misunderstood. As an EMS leader, the communities you serve are almost guaranteed to be asking you about your response time more than any other topic.

It's important to educate local officials on the history and science of response time calculations and standards. For example, communities have not consistently defined how to calculate response time, often not counting some components, such as call processing and dispatching time, that affect the patient's experience.

You should be clear with community leaders on when the response time clock starts, and when it stops, and which standards apply to your community.

Finally, recent medical research, again, is finding that while faster is better for a small number of patients, most communities are unable to decrease response time enough to truly impact outcomes on the most critical patients.

2. Should all 911 calls for EMS receive a lights and sirens response"
Historically, most fire or EMS services responded to every call with emergency lights activated and sirens blaring. This is no longer a best practice, especially when multiple emergency vehicles are assigned to the event.

Today, progressive 911 centers can use validated protocols to assess the severity of the emergency call, and dispatch emergency responders at the appropriate level of urgency. Often times, only the closest and appropriate vehicle will use lights and siren while other units follow normal traffic laws until additional information determines otherwise. Risk management has shown this is a more prudent practice for the patient and all residents on the road in the community.

3. Do you have the same number of calls at 2 a.m. as you do at 2 p.m."
The answer to this question is almost always no, and your community needs to understand that in order to properly fund an effective and efficient system. Calls for emergency medical services follow a fairly predictable temporal pattern in almost every city and county: Fewer calls overnight, an uptick starting in the early morning, and then a peak in mid-afternoon before falling through the evening hours.

Yet many systems still deploy the same of number of vehicles at 2:00 a.m. as they do at 2:00 p.m. In lieu of simply adding more 24-hour crews for increasing demand, some communities are increasingly turning to peak-hour units. These vehicles are only deployed for 10-, 12- or 14-hour periods during the busiest hours — thereby providing a more cost-effective method of addressing the increase in calls for EMS service.

If you don't know the peaks and valleys of your own agency's call volume, you can't have an honest conversation with the community's leaders about resources, staffing and funding.

4. Why does an EMS agency have a medical director"
Some municipal leaders think of EMS as just another public safety function, run by a chief. They don't always understand that EMS is providing health care and therefore needs adequate medical supervision.

The medical director should be an active participant in the decision-making process, and should be as familiar a face to your local elected and appointed officials as the fire chief or EMS agency leader. Your city or county manager, mayor or councilmembers need to know that the medical director plays a major role in establishing levels of service, training EMS personnel and establishing protocols that permit, or do not permit, the use of call prioritization and alternate deployment models. Local leaders should take the time to understand the medical director's perspective on providing quality EMS in your community.

5. How does health care reform impact EMS"
Just as many communities don't think of EMS as health care, many don't realize the potential impacts of health care reform on emergency services. They need to be aware of both the threats and the opportunities.

The Patient Protection and Affordable Care Act is only a piece of the government's efforts to make health care more affordable, which could mean less revenue from ambulance transports. And while there is tremendous interest in and discussion about community paramedicine along with other community-based health programs, we really don't know what the future will bring.

Your community's leaders need to understand what Obamacare and other models of care could mean for EMS. It is more important than ever for EMS systems and their leaders to be engaged with other community partners, including social services, public health and hospitals and other providers.

What are other questions have you answered for your city and county officials" Share those questions and answers in the comments.

About the author
Bruce Moeller, PhD, a senior consultant with Fitch & Associates, has extensive experience in both the fire service and city and county management. He served as fire chief in multiple departments, including Broward County, Florida, and later was city manager in Sunrise, Florida, and executive director for safety and emergency services in Pinellas County, Florida.



from EMS via xlomafota13 on Inoreader http://ift.tt/1qb96L2
via IFTTT

Chicago Fire Department strips paramedics of PPE

A fire department spokesman said paramedics aren't sent into areas where they need it; union officials say that is not true

from EMS via xlomafota13 on Inoreader http://ift.tt/1WY7hOu
via IFTTT

Remember 2 Things: Stroke mimics

Several conditions mimic or look like stroke. Remember the two things - hypogylcemia and seizures - that can often look like stroke in this EMS1 training video from Steve Whitehead. After watching share your experience with stroke scales in the comments, watch another episode of Remember 2 Things on improving stroke recognition and response, and read more about stroke assessment scales.

from EMS via xlomafota13 on Inoreader http://ift.tt/1OlDqZG
via IFTTT

Trachway(®) stylet: a perfect tool for nasotracheal intubation - a reply.

Related Articles

Trachway(®) stylet: a perfect tool for nasotracheal intubation - a reply.

Anaesthesia. 2016 Jun;71(6):725

Authors: Cheng KI, Lee MC, Tseng KY, Shen YC

PMID: 27158994 [PubMed - as supplied by publisher]



from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/27axsq3
via IFTTT

Trachway(®) stylet: a perfect tool for nasotracheal intubation?

Related Articles

Trachway(®) stylet: a perfect tool for nasotracheal intubation?

Anaesthesia. 2016 Jun;71(6):724

Authors: Hsieh SW, Hung KC

PMID: 27158992 [PubMed - as supplied by publisher]



from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/27axqyt
via IFTTT

Nasotracheal intubation and epistaxis.

Related Articles

Nasotracheal intubation and epistaxis.

Anaesthesia. 2016 Jun;71(6):722-723

Authors: Vivian V, van Zundert AA

PMID: 27158991 [PubMed - as supplied by publisher]



from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/27axoGO
via IFTTT

Want to know the pay expectations of paramedics? Start by asking!

By Nathan Harig

Like many areas nationwide, my region of south central Pennsylvania is experiencing a shortage of EMTs and paramedics. One of our most popular paramedic education programs graduated only 10 paramedics at the end of last year for a region served by about 40 ALS agencies, most with current employment vacancies.

Many agencies are competing to see who can offer the most attractive sign-on bonuses or compensation package to woo prospective employees. The agency I work for, Cumberland Goodwill EMS in Carlisle, Pa., has felt this pinch too and decided to put our own twist on our recruiting efforts.

Earlier this year, we exhibited at EMS Today in Baltimore to do some nationwide recruiting, but it wasn't just about selling our company to prospective employees. We wanted to assess some quick vital signs on the industry to see how we can attract top candidates.

While we know what salary surveys say average pay is, we weren't certain the expectations of providers were close to the real compensation provided. To study this, we ran a nonscientific survey at our booth that assessed basic demographics, current benefits, important factors in choosing an EMS employer and happiness with their current organization.

To encourage responses, we held a daily drone giveaway. We had 99 unique responses to our online survey. Our median age for EMTs was 27, while the median for paramedics was 38. Respondents came from North Carolina, Virginia, Maryland, Pennsylvania, New Jersey, or New York, producing a regional bias that, while it serves our interests when recruiting, may mean these stats are not applicable nationally.

What is a reasonable hourly pay rate (not including benefits) to pay someone with your certification?
In an effort to ensure that the data wasn't skewed one way by a large or small value, we opted to use the statistical median in our assessment and omitted volunteer or $0.00 responses for this question.

EMT respondents suggested $15/hour was reasonable, while paramedics assessed $25/hour to be reasonable. This was right around our expectations, especially in light of trends nationwide pushing for a $15/hour minimum wage for EMS workers.

What fringe benefits are offered at your current EMS organization?
We were particularly concerned with the fringe benefits offered to providers. At Cumberland Goodwill EMS, our full-time employees enjoy things like paid health care with no payroll deduction for the employee and their families, accrual-based paid time off per pay and 401k with employer matching. Still, we weren't certain how this stacks up against the rest of the industry. Overall we found our benefit package to be very competitive to those received by respondents.

Which factors are important when choosing an EMS organization?
We were also very interested in knowing what was important to a prospective employee. While we hypothesized pay and benefits would be the most important factors, we were surprised to see just how low the desire to be at a 911-only service was. In fact, many respondents believed being close to where they grew up was important when picking a squad; something that poses a challenge with our nationwide recruitment effort. While this poses a setback for our nationwide recruitment, we believe that we can overcome it by focusing on other important factors.

Are you considering switching EMS services or employers?
When asked If they were considering switching EMS services, only 12.1 percent indicated they were actively searching. Thirty-one percent indicated that they were willing to switch if the right offer came along. A solid 56.6 percent indicated that they were happy at their current service.

How important is cost of living?
While it wasn't a question on our online survey, in one-on-one interviews with prospective candidates the cost of living was one of the biggest selling points for our area. A three-bedroom home in our area can be rented for around $700/month, with many homes selling for around $150,000.

The salary needs of EMS providers greatly changes when factoring in living costs and deductions from their payroll. One of the ideas we've considered has been rent or housing assistance, partnering with realtors to find housing and covering the first month's rent to help a new employee settle in the area. The data suggests this would be a completely unique benefit and may help bring in providers from outside our region.

As we move through the recruiting process and our own ongoing evaluation of benefits, we'll use the data we collected in Baltimore to make decisions that net our agency top talent. EMS agencies nationwide should be do similar evaluations. As educational standards and call volume continue to rise, total compensation at your agency may need to change as well. While it's great to be able to recruit hometown responders, enticing new talent outside of their comfort zone may be necessary, especially in the case of the shortage facing south central Pennsylvania. This data was a good starting point, but our work at Cumberland Goodwill EMS has only just begun.  

About the author
Nathan Harig is the Assistant Chief of Administration at Cumberland Goodwill EMS in Carlisle, Pennsylvania, where he oversees technology, data and quality management, outreach, and public relations for the department. A paramedic, Nathan also holds a Bachelors of Arts in Political Science from Saint Vincent College in Latrobe, Pennsylvania and a Masters of Arts in TransAtlantic Studies from Jagiellonian University in Krakow, Poland.



from EMS via xlomafota13 on Inoreader http://ift.tt/1T3fFaV
via IFTTT

5 questions EMS leaders need to answer for city and county officials

By Bruce Moeller, Ph.D.

Most city and county officials have never had the opportunity — or thrill — of responding lights and sirens to a resident's home in order to provide lifesaving medical care.

And while that imagery can serve as a powerful argument for unwavering support and funding of your EMS program, municipal leaders, both elected and appointed, have many competing priorities and need to make themselves more knowledgeable of current and emerging issues in the delivery of EMS — and what they can do to ensure the community's EMS needs are being met.

EMS leaders also need to play a role in educating city and county administrators so they are making informed decisions about EMS service. Here is a series of five questions that EMS leaders should explore with their local officials to improve their understanding of this vital service and effectively manage the community's expectations for emergency medical care.

1. What are your community's expectations for EMS services?
This is a difficult question to answer, for the city manager, EMS chief or even the public. A community's expectations for EMS services are often vague — residents want fast and effective EMS, but don't always know what that means.

The first issue is typically the level of service to provide — basic life support or advanced life support. While the ALS level has historically been the gold standard of care, there continue to be well-researched medical studies suggesting that ALS care makes a significant difference for only a small number of patients.

You will likely find that citizen expectations will often match the level of service they have received historically. So while you can always upgrade from BLS to ALS, it is extremely difficult to reduce back down to a lower level of care, even in cases when it might be as effective and more efficient to do so.  

Response time has historically been the one measure of system performance most measured and talked about — and the most misunderstood. As an EMS leader, the communities you serve are almost guaranteed to be asking you about your response time more than any other topic.

It's important to educate local officials on the history and science of response time calculations and standards. For example, communities have not consistently defined how to calculate response time, often not counting some components, such as call processing and dispatching time, that affect the patient's experience.

You should be clear with community leaders on when the response time clock starts, and when it stops, and which standards apply to your community.

Finally, recent medical research, again, is finding that while faster is better for a small number of patients, most communities are unable to decrease response time enough to truly impact outcomes on the most critical patients.

2. Should all 911 calls for EMS receive a lights and sirens response? 
Historically, most fire or EMS services responded to every call with emergency lights activated and sirens blaring. This is no longer a best practice, especially when multiple emergency vehicles are assigned to the event.

Today, progressive 911 centers can use validated protocols to assess the severity of the emergency call, and dispatch emergency responders at the appropriate level of urgency. Often times, only the closest and appropriate vehicle will use lights and siren while other units follow normal traffic laws until additional information determines otherwise. Risk management has shown this is a more prudent practice for the patient and all residents on the road in the community.

3. Do you have the same number of calls at 2 a.m. as you do at 2 p.m.?
The answer to this question is almost always no, and your community needs to understand that in order to properly fund an effective and efficient system. Calls for emergency medical services follow a fairly predictable temporal pattern in almost every city and county: Fewer calls overnight, an uptick starting in the early morning, and then a peak in mid-afternoon before falling through the evening hours.

Yet many systems still deploy the same of number of vehicles at 2:00 a.m. as they do at 2:00 p.m. In lieu of simply adding more 24-hour crews for increasing demand, some communities are increasingly turning to peak-hour units. These vehicles are only deployed for 10-, 12- or 14-hour periods during the busiest hours — thereby providing a more cost-effective method of addressing the increase in calls for EMS service.

If you don't know the peaks and valleys of your own agency's call volume, you can't have an honest conversation with the community's leaders about resources, staffing and funding.

4. Why does an EMS agency have a medical director?
Some municipal leaders think of EMS as just another public safety function, run by a chief. They don't always understand that EMS is providing health care and therefore needs adequate medical supervision.

The medical director should be an active participant in the decision-making process, and should be as familiar a face to your local elected and appointed officials as the fire chief or EMS agency leader. Your city or county manager, mayor or councilmembers need to know that the medical director plays a major role in establishing levels of service, training EMS personnel and establishing protocols that permit, or do not permit, the use of call prioritization and alternate deployment models. Local leaders should take the time to understand the medical director's perspective on providing quality EMS in your community.

5. How does health care reform impact EMS?
Just as many communities don't think of EMS as health care, many don't realize the potential impacts of health care reform on emergency services. They need to be aware of both the threats and the opportunities.

The Patient Protection and Affordable Care Act is only a piece of the government's efforts to make health care more affordable, which could mean less revenue from ambulance transports. And while there is tremendous interest in and discussion about community paramedicine along with other community-based health programs, we really don't know what the future will bring.

Your community's leaders need to understand what Obamacare and other models of care could mean for EMS. It is more important than ever for EMS systems and their leaders to be engaged with other community partners, including social services, public health and hospitals and other providers.

What are other questions have you answered for your city and county officials? Share those questions and answers in the comments.

About the author
Bruce Moeller, PhD, a senior consultant with Fitch & Associates, has extensive experience in both the fire service and city and county management. He served as fire chief in multiple departments, including Broward County, Florida, and later was city manager in Sunrise, Florida, and executive director for safety and emergency services in Pinellas County, Florida.



from EMS via xlomafota13 on Inoreader http://ift.tt/1T3fFaE
via IFTTT

Intrahepatic IP-10 mRNA and plasma IP-10 levels as response marker for HBeAg-positive chronic hepatitis B patients treated with peginterferon and adefovir

Antiviral Research

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1OdOL3f
via IFTTT

Effect of dilute apple juice and preferred fluids vs electrolyte maintenance solution on treatment failure among children with mild gastroenteritis: A randomized clinical trial

JAMA

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1TBJmyZ
via IFTTT

A prospective study of oral contraceptive use and colorectal adenomas

Cancer Causes and Control

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1OdOKMM
via IFTTT

Chinese Herbal Medicine and Fluorouracil-Based Chemotherapy for Colorectal Cancer: A Quality-Adjusted Meta-Analysis of Randomized Controlled Trials

Integrative Cancer Therapies

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1TBJoHl
via IFTTT

Association of Selective Serotonin Reuptake Inhibitors with Transfusion in Surgical Patients.

BACKGROUND: The clinical relevance of chronic exposure to selective serotonin reuptake inhibitors (SSRIs) to transfusion in surgical patients is unclear. METHODS: We conducted a prospective cohort study involving patients undergoing cardiac, vascular, spinal, and intracranial surgery at 2 academic medical centers. Medication use, demographics, comorbidities, and laboratory values were determined at baseline by patient interview and review of medical records. The primary outcome was transfusion of any hemostatic allogeneic blood product (i.e., fresh frozen plasma, platelets, and/or cryoprecipitate) through postoperative day 2. RESULTS: The study sample consisted of 767 patients; 364 patients (47.5%) underwent cardiac surgery and the remainder underwent noncardiac surgery. Eighty-eight patients (11.5%) used SSRIs preoperatively. Among cardiac patients, the absolute number of allogeneic transfusions was higher for SSRI users than nonusers (2 [0-6] vs 0 [0-2], median [25%-75%], respectively, P = 0.008), and a similar trend was observed for noncardiac surgery. After adjusting for covariates using ordinal logistic regression, preoperative SSRI use was associated with an approximately 2-fold (odds ratio, 2.2; 95% confidence interval, 1.2-3.98) increase in odds of exposure to allogeneic hemostatic blood products; similar results were observed using propensity score adjustment (odds ratio, 1.85; 95% confidence interval, 1.11-3.07). A significant interaction between SSRI use and surgery type, age, sex, or concurrent antiplatelet therapy was not found; however, heterogeneity in magnitude of effect could not be excluded. CONCLUSIONS: Preoperative use of SSRIs is associated with increased exposure to allogeneic hemostatic blood products in surgical patients at high risk for perioperative bleeding. Determining whether perioperative continuation or withdrawal of SSRIs produces a net clinical benefit requires randomized controlled trials. (C) 2016 International Anesthesia Research Society

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1T0Jtbp
via IFTTT

Coverage for hepatitis C drugs in medicare part D

The American Journal of Managed Care

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1OdOHR9
via IFTTT

The predictive value of noninvasive serum markers of liver fibrosis in patients with chronic hepatitis C

The Turkish Journal of Gastroenterology

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1TBJm2b
via IFTTT

Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study

International Journal of Cancer

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1OdOHQR
via IFTTT

Ethnic variations in duodenal villous atrophy consistent with celiac disease in the United States

Clinical Gastroenterology and Hepatology

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1TBJm1T
via IFTTT

An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake

Cancer Causes and Control

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1OdOFbT
via IFTTT

A study on morbidity and mortality pattern of poisoning in tertiary care hospital

2016-05-10T03-58-17Z
Source: International Journal of Research in Medical Sciences
C. Paranthakan, P.K.Govindarajan.
Background: The poisoning due to various reasons commonly occurs among population. Normally tertiary care hospitals receive large numbers of referral. During treatment many die due to poisoning. Objectives of the study were to find out the magnitude of admissions due to poisoning and to find out various type of poisoning and related mortality. Methods: The secondary data was collected from records available in Intensive care unit of toxicology department of tertiary care hospital. The admissions made due to various type of poisoning from Jan 2015 to Dec 2015 were included in this study. The data of nearly 947 patients were analyzed regarding to type of poising and mortality due to the poisoning. Statistical analysis like percentage, Chi-square test and mean variance significant were calculated. Results: Out of 947, 70% were male and 30% were female. Among patients admitted 44% were consumed organophosphorus compounds, 22% had snake bite and 13% were consumed rat killer paste. The other common but least were drugs, rat killer powder and kerosene poisoning. Among admitted with various type of poisoning overall mortality was 36% and 58% due to organophosphorus compounds, 16% with rate killer paste and 14% with snake bite. The snake bite mostly occurred in rainy season and it is statistically significant. Conclusions: Most of the poisoning due to organophosphorus shows that it is available very easily and also cheap. The death among the poisoning is due to delay in starting of the treatment and awareness should be made to avail medical care immediately after poisoning without delay.


from Scope via xlomafota13 on Inoreader http://ift.tt/24JHxeM
via IFTTT

Sanitation and hygiene-specific risk factors for moderate-to-severe diarrhea in young children in the Global Enteric Multicenter Study, 2007–2011: case-control study

PLoS Medicine

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1TBJlLq
via IFTTT

Assessment of fetal malnutrition by body mass index and intra uterine growth curves: a comparative study

2016-05-10T03-45-13Z
Source: International Journal of Contemporary Pediatrics
Madhava Kamath K., Swathi S. Rao, Rathika D. Shenoy.
Background: Assessment of fetal malnutrition (FM) is incomplete by intra uterine growth (IUG) charts where only single anthropometric measure like weight is used. Body mass index (BMI) is a weight to length ratio which is a sensitive indicator of malnutrition. This study was aimed at comparing the accuracy of various birth weight based IUG charts with Body mass index of the new-born babies in detection of FM and correlating the neonatal complications with the BMI and the birth weight. Methods: A cohort study was done with a sample of 1192 newborn babies with gestational ages from 34 to 40 weeks. The newborns were classified based on BMI and birth weight after plotting on the BMI charts and various IUG charts. The accuracy of the various IUG charts in identifying FM when compared to BMI was analyzed and correlated with neonatal complications. Results: The prevalence of FM was 26.59% on classifying using BMI charts which was the highest when compared to the IUG charts. The IUG charts misclassified the undernourished babies as well nourished. The incidence of complications was 26.3% among the babies with low BMI when compared to normal BMI (14.8%). The classification of the newborns according to IUG charts did not correlate with incidence of complications. Conclusions: BMI chart is most sensitive indicator of FM at birth and its use is highly recommended in a developing country like India. It helps us to target the under nourished babies, provide better nutritional care and also anticipate and prevent neonatal complications.


from Scope via xlomafota13 on Inoreader http://ift.tt/1UPgNUc
via IFTTT

A prospective study of autoantibodies to Ezrin and pancreatic cancer risk

Cancer Causes and Control

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1OdOH3r
via IFTTT

Exercise-based interventions for non-alcoholic fatty liver disease: a meta-analysis and meta-regression

Clinical Gastroenterology and Hepatology

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1TBJlv3
via IFTTT

The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor.

BACKGROUND: Sleep disruption in critically ill adults can result in acute decrements in cognitive function, including delirium, but it is underdiagnosed in the setting of the intensive care unit (ICU). Although sleep stages can be assessed by polysomnography (PSG), acquisition and interpretation of PSG is costly, is labor intensive, is difficult to do over an extended period of time with critically ill patients (multiple days of continuous recording), and may interfere with patient care. In this pilot study, we investigated the feasibility and utility of monitoring sleep in the ICU setting using a portable electroencephalography (EEG) monitor, the SedLine(R) brain monitor. METHODS: We first performed a baseline comparison study of the SedLine brain monitor by comparing its recordings to PSG recorded in a sleep laboratory (n = 3). In a separate patient cohort, we enrolled patients in the ICU who were monitored continuously with the SedLine monitor for sleep disruption (n = 23). In all enrolled patients, we continuously monitored their EEG. The raw EEG was retrieved and sleep stages and arousals were analyzed by a board-certified technologist. Delirium was measured by a trained research nurse using the Confusion Assessment Method developed for the ICU. RESULTS: For all enrolled patients, we continuously monitored their EEGs and were able to retrieve the raw EEGs for analysis of sleep stages. Overall, the SedLine brain monitor was able to differentiate sleep stages, as well as capture arousals and transitions between sleep stages compared with the PSG performed in the sleep laboratory. The percentage agreement was 67% for the wake stage, 77% for the non-rapid eye movement (REM) stage (N1 = 29%, N2 = 88%, and N3 = 6%), and 89% for the REM stage. The overall agreement was measured with the use of weighted kappa, which was 0.61, 95% confidence interval, 0.58 to 0.64. In the ICU study, the mean recording time for the 23 enrolled patients was 19.10 hours. There were several signs indicative of poor-quality sleep, where sleep was distributed throughout the day, with reduced time spent in REM (1.38% +/- 2.74% of total sleep time), and stage N3 (2.17% +/- 5.53% of total sleep time) coupled with a high arousal index (34.63 +/- 19.04 arousals per hour). The occurrence of ICU delirium was not significantly different between patients with and without sleep disruption. CONCLUSIONS: Our results suggest the utility of a portable EEG monitor to measure different sleep stages, transitions, and arousals; however, the accuracy in measuring different sleep stages by the SedLine monitor varies compared with PSG. Our results also support previous findings that sleep is fragmented in critically ill patients. Further research is necessary to develop portable EEG monitors that have higher agreement with PSG. (C) 2016 International Anesthesia Research Society

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1Yjazuw
via IFTTT

Association between breast cancer recurrence with immunosuppression in rheumatoid arthritis and inflammatory bowel disease: A cohort study

Arthritis & Rheumatism

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1OdOEEX
via IFTTT

Neuraxial Anesthesia in Parturients with Low Platelet Counts.

The obstetric anesthesiologist must consider the risk of spinal-epidural hematoma in patients with thrombocytopenia when choosing to provide neuraxial anesthesia. There are little data exploring this complication in the parturient. In this single-center retrospective study of 20,244 obstetric patients, the incidence of peripartum thrombocytopenia (platelet count

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1T0JtZ1
via IFTTT

Dose-escalation study of a second-generation non-ansamycin HSP90 inhibitor, onalespib (AT13387), in combination with imatinib in patients with metastatic gastrointestinal stromal tumour

European Journal of Cancer

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1TBJluU
via IFTTT

The CNAP(TM) Finger Cuff for Noninvasive Beat-To-Beat Monitoring of Arterial Blood Pressure: An Evaluation in Intensive Care Unit Patients and a Comparison with 2 Intermittent Devices.

BACKGROUND: Continuous and intermittent noninvasive measurements of arterial blood pressure (BP) have not been compared in the same population. In a large panel of intensive care unit patients, we assessed the agreement between CNAP(TM) (Continuous Noninvasive Arterial Pressure) finger cuff beat-to-beat monitoring of BP and reference intraarterial measurements. Two automated oscillometric brachial cuff devices were also tested: CNAP brachial cuff (used for CNAP finger cuff calibration) and an alternative device. The performance for detecting hypotension (intraarterial mean BP 10%), and hypertension (intraarterial systolic BP >140 mm Hg) was evaluated. We also assessed the between-calibration drift of CNAP finger cuff BP in specific situations: cardiovascular intervention or no intervention. METHODS: With each device, 3 pairs of noninvasive and intraarterial measurements were prospectively collected and analyzed according to current guidelines, the International Organization for Standardization (ISO) standard. The trending ability and drift of the CNAP finger cuff BP were assessed over a 15-minute observation period. RESULTS: In 182 patients, CNAP finger cuff and CNAP brachial cuff readings did not conform to ISO standard requirements (mean bias +/- SD exceeding the maximum tolerated 5 +/- 8 mm Hg), whereas the alternative automated brachial cuff succeeded for mean and diastolic BP. CNAP finger cuff trending ability was poor (concordance rate =0.91, positive and negative likelihood ratios >=5 and

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1YjaBCQ
via IFTTT

Change in chemotherapy during concurrent radiation followed by surgery after a suboptimal positron emission tomography response to induction chemotherapy improves outcomes for locally advanced esophageal adenocarcinoma

Cancer

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1OdOGwt
via IFTTT

The Effect of Local Anesthetic Volume Within the Adductor Canal on Quadriceps Femoris Function Evaluated by Electromyography: A Randomized, Observer- and Subject-Blinded, Placebo-Controlled Study in Volunteers.

BACKGROUND: Single-injection adductor canal block (ACB) provides analgesia after knee surgery. Which nerves that are blocked by an ACB and what influence-if any-local anesthetic volume has on the effects remain undetermined. We hypothesized that effects on the nerve to the vastus medialis muscle (which besides being a motor nerve innervates portions of the knee) are volume-dependent. METHODS: In this assessor- and subject-blinded randomized trial, 20 volunteers were included. On 3 separate days, subjects received an ACB with different volumes (10, 20, and 30 mL) of lidocaine 1%. In addition, they received a femoral nerve block and a placebo ACB. The effect on the vastus medialis (primary endpoint) and the vastus lateralis was evaluated using noninvasive electromyography (EMG). Quadriceps femoris muscle strength was evaluated using a dynamometer. RESULTS: There was a statistically significant difference in EMG response from the vastus medialis, dependent on volume. Thirty-five percent (95% confidence interval [CI], 18-57) of the subjects had an affected vastus medialis after an ACB with 10 mL compared with 84% (95% CI, 62-94) following 20 mL (P = 0.03) and 100% (95% CI, 84-100) when 30 mL was used (P = 0.0001). No statistically significant differences were found between volume and effect on the vastus lateralis (P = 0.81) or in muscle strength (P = 0.15). CONCLUSIONS: For ACB, there is a positive correlation between local anesthetic volume and effect on the vastus medialis muscle. Despite the rather large differences in EMG recordings, there were no statistically significant differences in quadriceps femoris muscle strength. Subsequent clinical studies comparing different volumes in a surgical setting, powered to show differences not only in analgesic efficacy, but also in adverse events, are required. (C) 2016 International Anesthesia Research Society

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1T0JtIs
via IFTTT

ARCII: A phase II trial of the HIV protease inhibitor Nelfinavir in combination with chemoradiation for locally advanced inoperable pancreatic cancer

Radiotherapy & Oncology

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1rPqSEY
via IFTTT

Preoperative Troponin in Patients Undergoing Noncardiac Surgery: Is Timing Everything?.

No abstract available

from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1Yjaze4
via IFTTT

A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy

Cancer

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1XiUczN
via IFTTT

Advanced Diagnostic Genetic Testing In Inherited Retinal Disease:Experience from a Single Tertiary Referral Centre in the UK National Health Service

ABSTRACT

Background/Aims

In 2013, as part of our genetic investigation of patients with Inherited Retinal Disease, we utilised multigene panel testing of 105 genes known to cause retinal disease in our patient cohorts. This test was performed in a UK National Health Service (NHS) accredited laboratory.

Method

The results of all multigene panel tests requested between 1.4.13 and 31.8.14 were retrospectively reviewed. All patients had been previously seen at Moorfields Eye Hospital, London, UK and diagnosed with an inherited retinal dystrophy after clinical examination and detailed retinal imaging.

Result

The results were categorised into three groups: 1) Testing helped establish a certain molecular diagnosis in 45/115 (39%). Variants in USH2A (n = 6) and RP1 (n = 4) were most common.

2) Definitive conclusions could not be drawn from molecular testing alone in 13/115 (11%) as either insufficient pathogenic variants were discovered or those identified that were not consistent with the phenotype.

3) Testing did not identify any pathogenic variants responsible for the phenotype in 57/115 (50%).

Conclusion

Multigene panel testing performed in an NHS setting has enabled a molecular diagnosis to be confidently made in 40% of cases. Novel variants accounted for 38% of all identified variants. Detailed retinal phenotyping helped the interpretation of specific variants. Additional care needs to be taken when assessing polymorphisms in genes that have been infrequently associated with disease, as historical techniques were not as rigorous as contemporary ones. Future iterations of sequencing are likely to offer higher sensitivity, testing a broader range of genes, more rapidly and at a reduced cost.

Thumbnail image of graphical abstract

from Genetics via xlomafota13 on Inoreader http://ift.tt/27a7Olj
via IFTTT

Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

Clinical Cancer Research

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1WXATvw
via IFTTT

In vivo physiological recording from the lateral line of juvenile zebrafish

Hair cells are sensory receptors responsible for transducing auditory and vestibular information into electrical signals, which are then transmitted with remarkable precision to afferent neurons. The zebrafish lateral line is emerging as an excellent in vivo model for genetic and physiological analysis of hair cells and neurons. However, research has been limited to larval stages because zebrafish become protected from the time of independent feeding under European law (from 5.2 days post-fertilization, dpf, at 28.5°C). In larval zebrafish, the functional properties of hair cells, as well as those of other excitable cells, are still immature. We have developed an experimental protocol to record electrophysiological properties from hair cells of the lateral line in juvenile zebrafish. We found that the anaesthetic benzocaine at 50 mg l-1 was an effective and safe anaesthetic to use on juvenile zebrafish. Concentrations up to 300 mg l-1 did not affect the electrical properties or synaptic vesicle release of juvenile hair cells, unlike the commonly used anaesthetic MS-222, which reduces the size of basolateral membrane currents. Additionally, we implemented a method to maintain gill movement, and as such respiration and blood oxygenation, via the intubation of > 21 dpf zebrafish. The combination of benzocaine and intubation provides an experimental platform to investigate the physiology of mature hair cells from live zebrafish. More generally, this method would allow functional studies involving live imaging and electrophysiology from juvenile and adult zebrafish.

This article is protected by copyright. All rights reserved



from Physiology via xlomafota13 on Inoreader http://ift.tt/1ZAaS4A
via IFTTT