FORMULATION AND EVALUATION OF GASTRORETENSIVE FLOATING TABLETS OF VENLAFAXINE HCl

2016-08-09T05-51-53Z
Source: Indo American Journal of Pharmaceutical Research
N. Lakshmi Prasanthi*, Ayya. Rajendra Prasad, K. Durga, M. Durga Nageswara Rao.
The purpose of the study was to develop the gastro retentive floating tablets of venlafaxine HCl is an antidepressant which are designed to increase the gastric residence time, thus prolonging the drug release in the present study The tablets were prepared by direct compression technique using different polymers like HPMC K4M, Carbopol 940 and sodium bicarbonate as gas generating agent. The prepared tablets were evaluated for different parameters like hardness, friability, uniformity of weight, in vitro buoyancy studies, and in vitro dissolution studies. The FTIR studies revealed that there was no interaction between the drug and excipients. The tablets containing weight variation of 0.17mg±0.15mg to 0.62mg±0.36mg, hardness of 4.2kg/cm2±0.34kg/cm2 to 5.2kg/cm2±0.63kg/cm2, percentage friability was found to be less than one, thickness of 3mm±0.27mm to 4.6mm±0.025mm, venlafaxine HCl released 92.25±2.9 to 93.35±2.1% of the drug at the end of 10th hour by in vitro release study. The formulation F9 was selected as an optimized formula because it gave best results in terms of the required in vitro buoyancy study, good floating integrity, and drug release in sustained release manner and best fitted to zero order release kinetics with r2 value of 0.94.


from Scope via xlomafota13 on Inoreader http://ift.tt/2aJ4h6f
via IFTTT