FORMULATION AND EVALUATION OF LIPOSOMAL GEL CONTAINING ANTIFUNGAL ACTIVITY – KETOCONAZOLE

2016-08-09T05-51-53Z
Source: Indo American Journal of Pharmaceutical Research
Deevan Paul*, Vothani Sarath Babu.
Liposomal carriers, well known for their potential in topical drug delivery have been chosen to help fungal infections in the skin layers. A development of system which controls the release and enhances the bioavailability of Ketoconazole, an fungal activity is in demand. In the present work statistical study for the formulation of Liposomes for topical delivery of Ketoconazole Liposomal gel using the factorial design approach was undertaken. Ketoconazole, Soya lecithin, Cholesterol were dissolved in mixture of chloroform and methanol (9:1) were taken in different levels and liposomes were prepared using thin film hydration technique. Gel containing Liposomes for optimised batch were prepared in Carbopol® 940. The FT-IR spectroscopy study was carried out to check out the compatibility between the drug Ketoconazole and the excipients used for the preparation. These include average particle size and size distribution, shape, encapsulation efficiency, Percentage drug content, In-vitro drug release study. The compatibility study of the prepared Ketoconazole Liposomes showed no interaction between drug and excipients. The size of liposomal formulations ranged from 3.278- 19.688μm. The entrapment efficiency of drug increased when molar ratio of lipid to cholesterol was changed from 1:1% Drug content of liposomal formulations obtained shows 94.6 - 99.2% drug content. Liposomal dispersion and gel were found to increase the skin permeation and deposition compared to control and marketed gel. Hence it can be concluded that Ketoconazole can also be loaded in liposomal carriers which found to be effective, stable and can be preceded for further future studies.


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